Lol the human body clears proteins a lot. Even the proteins you naturally produce aggregates. Our insulin, our Amylin, Our GH, it all aggregates. Some people naturally have issues clearing aggregates and that causes a whole lot of problems. This is not the same thing as aggregates in peptides causing issues. Yes, synthetic peptides can aggregate, yes aggregates can be toxic to cells.. but the reality is that common things occur commonly. Uncommon things, uncommonly. There are so many people doing stuff now that of these issues were very common, the anecdotes will be overwhelming. You cant hide immune reactions.
My advice is to filter if you are worried and stop taking a peptide if you have Severe ISR even after proper injection techniques. Definitely stop taking if you have a (severe) hypersensitivity reaction.
Afterall there are aggregates that will still pass through the .22 micron filter most people use.
If you are not having any reactions keep on keep keeping on...
Ahhh, the compelling power of bro science.
It's so soothing.
TLDR: "If you don't lose an ass cheek, it's obviously fine".
I wonder what immunogenicity inducing growth hormone treatment failure feels like in the years it builds up to the point doctors noticed a lack of progress?
Another great point, some aggregates can pass through a .22um filter. So don't bother trying to eliminate the much larger aggregates most closely associated with immunogenicity. Got that? It makes perfect sense. You can't possibly eliminate all bacteria with your alcohol swab, so don't wipe your vial stoppers and stop wasting syringes. Plenty of gym bros have used the same pin dozens of times, year after year without issue. You're not sharing them with someone who's got AIDS, right? See, isn't "down home" common sense so comforting?
While we're at it, nevermind all the other particulate shit found in UGL vials. Injecting that on a daily basis isn't an issue either. Rubber, glass, metal. You haven't lost a body part right? The body clears all that stuff....somehow, so it doesn't cause micro emboli or get lodged in your organs, building up over thousands of injections,
Don't listen to what the FDA, and countless scientists refer to as a "critical" aspect of protein drug safety, the control of which is entirely ignored in UGL peptides, and then pretend UGL proteins must be just as safe because pharma largely is,
And we "eliminate proteins", so there's another great, reassuring point that science hasn't quite picked up on yet as they and the pharma industry pour massive resources into studying aggregation, the immunogenicity it induces, and how to reduce the threat, Those eggheads completely missed the body's ability to identify and immediately eliminate any weird synthetic protein aggregate not seen in nature. What a bunch of idiots .
See, here on MESO, particularly in this garbage thread, nuance doesn't exist. If something doesn't cause immediate, dramatic injury, it's not an issue. "Long term consequences" or "managing known but difficult to quantify risks" is scoffed at.
So don't take the simple precaution of filtering the particulates and aggregates out of the stuff you inject into yourself.
But be sure to keep drinking bottled water and change the filter in your refrigerator every 6 months....