Travelling with prefilled syringes

[undersc0re]

I work away from home up to 48 hrs and was wondering if its ok to prefill insulin syringes with peptides and put the cap back on and carry them in an insulin type cooler? Is this possible without any concern? Am I better off just carrying the vials with me in the cooler instead of prefilling? I would usually only maybe 2 injections.

 

[Ghoul]

It's not ideal but for 48 hours it's keeping it cold and protecting from light that will be the biggest factors.

If I were doing this routinely, I'd use silicone free syringes, since that's the main problem with prefilling. The silicone lubricant in syringes degrades and promotes protein aggregation, especially when the syringes are agitated.

Prefilled pens with peptide/protein drugs are silicone free for this reason.

 

[AlexDavis43]

I work away from home up to 48 hrs and was wondering if its ok to prefill insulin syringes with peptides and put the cap back on and carry them in an insulin type cooler? Is this possible without any concern? Am I better off just carrying the vials with me in the cooler instead of prefilling? I would usually only maybe 2 injections.

That's pretty much how they'd be stored anyway. Bonus points for keeping them cool.

 

[undersc0re]

I guess I will set something up for the vials and just draw and inject when needed instead of prefilling! Was just concerned about the vials being exposed to warmer temps for too long, but I will just be careful

 

[Here2Learn]

I bought an insulin pack that you freeze the insert before traveling. It wouldn’t last 48 hours though.

 

[undersc0re]

I bought an insulin pack that you freeze the insert before traveling. It wouldn’t last 48 hours though.

I am going to put the cooler in another cooler and see how it works out. Keeping it out of light isn’t an issue, hopefully I can keep it cool without freezing it

 

[Firebug]

I have used pre-filled syringes for a few years. Pre-fill for 72-96 hours. There is truth in what Goul says but I keep mine cool and out of light in a 3D printed case.

I was involved in a study a few years ago at the hospital I was working at. We pre-drew numerous meds and let them sit for 8 days. There was no contamination or issues found. It was a small study repeated over many weeks but it was for a very large organization and they now allow meds to be pre-drawn for up to 8 days now. I'm not saying it means its 100% safe or it was a perfect study.

I'm sure I have injected small amounts of silicone but I haven't had any issue at the injection site or otherwise so far. Keeping my fingers crossed!

 

[undersc0re]

I have used pre-filled syringes for a few years. Pre-fill for 72-96 hours. There is truth in what Goul says but I keep mine cool and out of light in a 3D printed case.

I was involved in a study a few years ago at the hospital I was working at. We pre-drew numerous meds and let them sit for 8 days. There was no contamination or issues found. It was a small study repeated over many weeks but it was for a very large organization and they now allow meds to be pre-drawn for up to 8 days now. I'm not saying it means its 100% safe or it was a perfect study.

I'm sure I have injected small amounts of silicone but I haven't had any issue at the injection site or otherwise so far. Keeping my fingers crossed!

So pre filled as in using an insulin syringe with needle, drawing up a needed amount, and putting the protective cap back over the needle? Just want to make sure we are not talking back filling or anything else.
I am trying my best to hold off using this method, just causes irregular scheduled doses. I am sure different manufacturers probably use different materials and manufacturing methods but imagine that was taken into account during testing. It would just be bac water based peptides in the syringes for most likely less than 24-28 hours.

 

[Ghoul]

. I am sure different manufacturers probably use different materials and manufacturing methods but imagine that was taken into account during testing.

What kind of testing do you think a small experiment at a hospital would involve?

Aggregates? Leached contaminants?

When someone. says "I injected X and had no problems", what exactly would constitute a problem? Feeling sick? Developing an infection at the site?

By that standard, I could drink out of a lead cup every day and sleep on an asbestos powder mattress for 10 years and "never have a problem".

 

[Firebug]

So pre filled as in using an insulin syringe with needle, drawing up a needed amount, and putting the protective cap back over the needle? Just want to make sure we are not talking back filling or anything else.
I am trying my best to hold off using this method, just causes irregular scheduled doses. I am sure different manufacturers probably use different materials and manufacturing methods but imagine that was taken into account during testing. It would just be bac water based peptides in the syringes for most likely less than 24-28 hours.

I'm talking about pre-filling insulin syringes. Peps with bac water is definitely better then using Test with oils. The oils lead to more breakdown of the silicone then water. I have been told the liquid in the syringe will get cloudy with breakdown. I have never experienced this. But I have never had my syringes trusted after 96 hours so I can't verify the exact amount of breakdown that is occurring.

 

[Firebug]

What kind of testing do you think a small experiment at a hospital would involve?

Aggregates? Leached contaminants?

When someone. says "I injected X and had no problems", what exactly would constitute a problem? Feeling sick? Developing an infection at the site?

By that standard, I could drink out of a lead cup every day and sleep on an asbestos powder mattress for 10 years and "never have a problem".

We did check for contaminants. I don't believe aggregates, but we might have. It was through a large University, we had no limits on what we could test for. It was just a matter of what the Physicians and PHD researches wanted. It was years ago and I have been involved in many research projects since and don't remember all of the details. But the outcome was no major concerns were found at the time. I don't typically work in Pharmacology have have not seen a similar study since.

Also to take in to consideration, these were all Pharma grade medications. Not UGL injectables.

 

[Dunkirk]

Today I used this idea to prefill insulin syringes with test, rather than taking a vial. I went through security without any issues. I will be using within 96 hours, hopefully it won't be an issue with degradation as mentioned here.

Obviously this isn't a guarantee that I will never be checked, but I noticed they were pulling quite a few bags to be checked at the airport. Out of 10 bags going through TSA, at least 6 were checked, it wasn't light at all. Mine went through without any concerns.

In a separate pouch, I had 2 insulin syringes in my carry on. The idea is that I'll be able to sell it as insulin rather than a 1" needle with the plan to inject them into my shoulders.

 

[Ghoul]

Today I used this idea to prefill insulin syringes with test, rather than taking a vial. I went through security without any issues. I will be using within 96 hours, hopefully it won't be an issue with degradation as mentioned here.

Obviously this isn't a guarantee that I will never be checked, but I noticed they were pulling quite a few bags to be checked at the airport. Out of 10 bags going through TSA, at least 6 were checked, it wasn't light at all. Mine went through without any concerns.

In a separate pouch, I had 2 insulin syringes in my carry on. The idea is that I'll be able to sell it as insulin rather than a 1" needle with the plan to inject them into my shoulders.

Test is a brick of a molecule. There won't be any degradation. A tiny amount of leeching from the plastic and rubber of not great chems, but you're not making a weekly habit of this so it won't amount to anything of concern.

 

[rxzed]

Today I used this idea to prefill insulin syringes with test, rather than taking a vial. I went through security without any issues. I will be using within 96 hours, hopefully it won't be an issue with degradation as mentioned here.

Obviously this isn't a guarantee that I will never be checked, but I noticed they were pulling quite a few bags to be checked at the airport. Out of 10 bags going through TSA, at least 6 were checked, it wasn't light at all. Mine went through without any concerns.

In a separate pouch, I had 2 insulin syringes in my carry on. The idea is that I'll be able to sell it as insulin rather than a 1" needle with the plan to inject them into my shoulders.

TSA is more likely to be on your ass for carrying too much toothpaste than a small vial or syringe.