SwolieGuacamole
Member
Same here. Seasonal depression paired with Acc is crushing. Fucking sucks.
Will have to look into t4
MESO-Rx
Anabolic Steroids
Accutane permanent cure?
- Thread starter Ghoul
- Start date
Will have to look into t4
nullandvoid
Member
Odd timing. So amongst everything else, I've been a caloric deficit for a significant amount of time.. to the point my rT3 is now above the top end of reference. I just last week added some (UGL) T3 totaling maybe 25mcg a day. It's Amino Asylum, so who really knows the actual strength? I have some pharma ordered, but it'll be a few weeks likely. So is it the T4 specifically that improves things, or the conversion to T3 that does it?
Don't really feel much improvement mood-wise, but it damn sure kicked up my BMR. A 25mcg Amino Asylum dose of T3 is probably 50mcg pharma. Another one of those things really better to just buy the real stuff.
Ghoul
Member
Most studies looking at T4 effectiveness measure in terms of perceived quality of life improvement by patients, and they're often quite dramatic,
Brand name T4 is like the cheapest pharma product you can buy from India.
It's $3-5 for 120 x 50mcg tablets.
There's already significant interest and controversy over the effectiveness of generic vs brand name T4 (many studies examining potential differences), with many patients claiming they feel very different from one brand to the next, and the FDA having to step in at one point to force an improvement in stability of generic formulations.
I can only imagine how unreliable UGL thyroid tabs must be in comparison, and on top of which. anything measured in mcg should really be left to professional pharma.
Look at the variance tests of UGL tabs with 100 times larger doses:
Last edited:
Started 40mg a day 8 days ago. Sides are minimal lips are a little dryer but not chapped, inside of nose feels weird, skin feels like the very beginning of a sunburn but not bad and eyes are a little dryer.
Going to bump the dose up at day 10 should I just jump up to 80 and see how that goes or do 60 for 10 days first?
Going to bump the dose up at day 10 should I just jump up to 80 and see how that goes or do 60 for 10 days first?
bighunanballs
Member
after about a month and half at 5mg/day micro dosing accutane ive noticed quite a bit of anxiety building up. im gonna stop for a few weeks and see if the anxiety relents. too much stressful shit going on right now to have an added pharmaceutical to the mix potentially modulating my anxiety state. if it goes away ill know its not the test/mast ive been cruising on for the last year
Ghoul
Member
I always bumped at least 50%, stayed at the higher level until sides started to subside then increased again, and repeat, For me, I the pattern was always that sides were worst for the first 3-5 days after increasing, then leveled off and started to ease. It wasn't until 2mg/kg, 180mg/day, that they showed no signs of subsiding, were intolerable, and I dropped back down after a week. By that point I was nearing cumulative goal anyway, and just keep dropping 20-40mg off the daily dosage each week. The climb down. At that point, once you've gotten that high, when you're dropping, it feels like there are no sides, even at 100mg/day. (except chelitis, ie, lips).
I decided extending the duration a little with lower doses was an acceptable tradeoff for some well deserved relief,
My lips, by the way, are no longer dry, and all that "exfoliation" stripped years of chapping damage off them. They look much better than before accutane, and less prone to chapping now than before.
Last edited:
My experience so far with Accutane has been pretty good. I initially was going to run low dose for a while but didn't really have a plan as to exactly how long. I tend to get acne on my back and chest plus the occasional face pimples when on cycle or when my estrogen is high so I decided I wanted to use Accutane in an attempt to minimize these problems. I stumbled upon this thread and basically got the motivation through what Ghoul wrote to just get it all done in one shot. I average roughly 190 pounds so to hit the 220mg/kg cumulative dosage which offers the best chance of avoiding relapse I'm aiming for a total of 18,960mg.
Here is the dosing that I've done so far:
10mg for 33 days
20mg for 7 days
40mg for 7 days
80mg for 4 days
120mg for 4 days
160mg for 29 days
180mg for 21 days (50 days remaining at this dose for completion)
Here is a list of the sides I've encountered so far:
Dry lips - this has been consistent throughout but gets better as I get use to the dose. I put aquaphor on my lips all day long.
Dry nose - starting at the 160mg I initially had 2 nose bleeds in a weeks time. That has stopped but my nose is still dry but tolerable. I also use a sleep apnea machine with nose pillows so I'm sure that makes it worse. When my nose first started getting dry I would just put some aquaphor in there which really helped.
Rash on back of hands - as soon as I went to 160mg the rash started. It didn't hurt but just looked bad. Around 3 weeks into the 160mg dose it started to go away. When I bumped up to 180mg it came back. I'm currently 3 weeks into the 180mg dose and it's going away now.
Achey joints - not sure if the joint pain is from Accutane or the heavy lifting but I'll note it.
Flaky skin - this was very minimal on my face but I did have a small period of time where I was a bit flaky. Nivea face cream has helped tremendously with combating it.
Outside of that I've had no real seroius problems. My skin on my face is very clear and my pores are visably smaller. I went through the sebaceous filament phase all along my nose, up the bridge of my nose to in between my eyebrows, and just around my nose. My chest, back, and shoulders are clear but I do have some scarring in those areas. I'm hopping the final 50 days clears this up. In addition, I will try to assist the scar healing by running some GLOW to see if it helps. I also will be doing the 8 week Ivermectin dosing as suggested by Ghoul because I have some red bumps on my back and shoulders. Just my experience but I hope it can help anyone thinking about taking Accutane.
Here is the dosing that I've done so far:
10mg for 33 days
20mg for 7 days
40mg for 7 days
80mg for 4 days
120mg for 4 days
160mg for 29 days
180mg for 21 days (50 days remaining at this dose for completion)
Here is a list of the sides I've encountered so far:
Dry lips - this has been consistent throughout but gets better as I get use to the dose. I put aquaphor on my lips all day long.
Dry nose - starting at the 160mg I initially had 2 nose bleeds in a weeks time. That has stopped but my nose is still dry but tolerable. I also use a sleep apnea machine with nose pillows so I'm sure that makes it worse. When my nose first started getting dry I would just put some aquaphor in there which really helped.
Rash on back of hands - as soon as I went to 160mg the rash started. It didn't hurt but just looked bad. Around 3 weeks into the 160mg dose it started to go away. When I bumped up to 180mg it came back. I'm currently 3 weeks into the 180mg dose and it's going away now.
Achey joints - not sure if the joint pain is from Accutane or the heavy lifting but I'll note it.
Flaky skin - this was very minimal on my face but I did have a small period of time where I was a bit flaky. Nivea face cream has helped tremendously with combating it.
Outside of that I've had no real seroius problems. My skin on my face is very clear and my pores are visably smaller. I went through the sebaceous filament phase all along my nose, up the bridge of my nose to in between my eyebrows, and just around my nose. My chest, back, and shoulders are clear but I do have some scarring in those areas. I'm hopping the final 50 days clears this up. In addition, I will try to assist the scar healing by running some GLOW to see if it helps. I also will be doing the 8 week Ivermectin dosing as suggested by Ghoul because I have some red bumps on my back and shoulders. Just my experience but I hope it can help anyone thinking about taking Accutane.
nullandvoid
Member
Show us those lips. Pics or it didn't happen.
SwolieGuacamole
Member
Still on 40mg e3d. No dry eyes or nose. Lips are chapped. Skin is getting a little ashy here and there. Depression is crushing. Absolutely terrible, to the point of constantly debating dropping it but can’t lol. It’s like 19nors x100. Completely empty and emotionless. Zero motivation. Starting to get anxiety. All I want to do is sleep, and have been sleeping the longest I have in years. None of which is typical for me. Pushing through but this stuff fucking sucks.
Went tanning twice and didn’t burn so that’s cool.
Went tanning twice and didn’t burn so that’s cool.
Last edited:
nullandvoid
Member
That rash on the back of hands is so weird. Is skin turnover there higher than other parts of the body or what? I had it, too, pretty bad in the beginning. Now it's barely visible. Only sides I have now are the dry lips and some rawness and a small sore in nose. My eyes have actually stopped being dry. Who knew eyeballs made oil? Not me.
Yea the hand rash is definitely weird. I also forgot too mention about the small nose sores. Mine aren't too bad but the nose pillows of my sleep apnea machine can dig into the them sometimes which is uncomfortable.
That really sucks that you are having that experience because if you have an acne problem this definitely seems to be the best way to combat it. Just goes to show that a lot of these things are so dependent on the individual.
Speaking of tanning, I can't wait to go but will prob be in like the middle of May. I just don't want to chance it at such a high dosage.
Last edited:
nullandvoid
Member
This past month I have been experiencing the same kind of depression, but in my case I finally figured out it was my introduction of low-dose Finasteride. I won't go into the details, but the depths you can get... it's right on that line.
Man that sucks mental sides are always a worry for me. But I’ve been lucky so far ran high dose NPP and Deca neither had any mental side effects at all for me hopefully it will be the same with accutane. I’m only 8 days on so far but did go to the beach Sunday for six hours lube up twice with sunscreen which I normally don’t use. Didn’t burn but I felt like I was cooking had to get under the umbrella a few times.
nullandvoid
Member
I forgot to mention, in spite of other sides lessening and disappearing, one recent one that has cropped up is damn ringworm. Gross. I researched it, and apparently there is a correlation. I am guessing I am picking it up from gym equipment, with my best guess being the pads or floor from doing side planks and other motions like up/downs. I guess leprosy is next.
Ghoul
Member
That every 3rd day dosing is causing wildly fluctuating blood levels of isotretinoin, more than 75% from peak to trough.
Constant levels, with 2x day dosing seem to experience the fewest sides, even at much higher doses.
Notice sides typically worsen when the dose is increased, then lessen after a few days. It may be the crazy fluctuations are stressing your system far more than would be happening without this unique schedule you're using.
Ghoul
Member
Jesus maybe hit the ivermectin now to eliminate that, and the demodex mites being starved of sebum, A twofer.
.2mg/kg, once a week for 8-10 weeks.
Iverjohn is a solid brand, and cheap from India,
nullandvoid
Member
I've got some UGL Ivermectin I'm sure is the exact labeled strength.
Ghoul
Member
It's pretty benign even at very high doses, much higher than we're taking about, so the worst case would be it's underdosed. I just rounded up from the 18mg needed to 24mg to make it easy (2x 12mg tabs). In the overwhelming majority of cases there are no sides whatsoever, You feel nothing. You could always just go a little higher than .2mg/kg to ensure it's enough,
Similar threads
