MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Not gonna lie, I looked into GLP-1 about a year ago and thought it was just another tool. But your posts actually made me look deeper into how it works, and I’m glad I did. Ended up being one of the smarter choices I’ve made. Props for sharing real info without the usual BS.
greenlocus
New Member
Any special considerations for ketovore / zerocarbers when on Reta?
Photon
Member
Each time I see reports like these, it makes me want to switch to Tirz. I've gotten no change in A1c from starting Ret and even at 15mg/week. I also get no appetite suppression either. I just cant eat as much in each meal else I get indigestion.
Eddie.
Member
Do you know where your previous A1c was? 4.9 is very good but that by itself doesn't tell much. Also, 4.9 while using 6+ IU HGH and having 600+ grams of carbs is very good, but for someone who doesn't use HGH and eats 300-400gr carbs wouldn't impress me.
My A1c used to stay in the 5.3–5.6 range. It’s been a steady 4.9 for the past year ever since I started Tirz. I’ve also been using 3–4iu of HGH daily for the last 7 months. Carbs vary - sometimes up to 400g, but currently around 150–200g since appetite’s been lower. So overall, I’m pretty satisfied with how things are looking.
Eddie.
Member
Awesome brother. I’m curious to find out what Reta did to me as well, although now I’m cutting and eating significantly less carbs.
Biggest difference on me so far was when I first started taking test and added berberine. Last natty labs I had 5,5 and 4 months later with 200mg test and 500mg berberine my A1c was 5. Later on after a bulk with more gear, 3,5 IU HGH and 700 carbs a day my A1c was 4,9 with 1000mg berberine. I guess Reta would do the same on bulk too.
12o3j129dq
New Member
Let's say you get Sema from a new seller and needed 2.5 mg from the old suppliers. How would you start with the dosage?
12o3j129dq
New Member
I no longer feel the full effect, only a very slight one. I have heard that there are new studies looking at 7.2 mg. Can I increase the dose to 3 mg myself?
bananafeet
Member
How long have you been on 2.5mg? I would wait at least a month to 6 weeks for the blood levels to stabilise.
Each dose stacks due to the long half life....
Ghoul
Member
The reason for Novo getting approval for doses up to 7.2mg is to address "weak responders" to 2.4mg.
The data clearly demonstrates safety at this point, and I don't see any reason you'd have an issue going to 3 or even higher.
But, it's always a good idea to wait until after at least 2 weekly doses before deciding to increase, because like banana said, it takes 4 weeks to experience the full effect. At least after 2 you'll know 75% of the strength of a given dose and can make a sensible decision.
After 5 weeks on 12.5mg, I decided to bump Tirz up to 15mg - you know, sticking to the official protocol. Not like 12.5mg stopped working, just need to start clearing out the stash before hopping on Reta.
Could I have given some Tirz away? Sure. But the little stingy Jew in me said, “No way - we don’t do freebies around here.”
Could I have given some Tirz away? Sure. But the little stingy Jew in me said, “No way - we don’t do freebies around here.”
Ghoul
Member
What do you intend to start Reta on? It seems 15mg Tirz is roughly equivalent to 8mg Reta.
Planning to follow the standard protocol - will start at 2mg and bump it up every 4 weeks by 2mg. I think somewhere around 6mg or 8mg will be the sweet spot. Appetite suppression isn’t the goal, I’ve always had good control there, but based on feedback from others, Reta seems to be a better fit for athletes or those who train consistently. That’s why I want to try it myself.
Eddie.
Member
I haven't been measuring my bp for a while now since it's usually hovers in the same spot either on cycle or not and after i did it yesterday i was quite shocked with my heart rate.
Bp is ok but RHR took a pretty big hit after increasing reta dose. I had a 7 points increase while on 1,5mg and after sometime at 6mg it went another 12+. Although i can't blame only reta for this, at the same time i increased the dose i added some low dose tren and probably this played some role too but i went from 67-70 to 88-90.
I have a week i reduced reta dose to 1,8mg per week since i couldn't stand the acid reflux and the bad digestion. Thankfully after only couple days no more waking in the middle of the night with puke in my mouth.
Now i want reduce rhr and I'm thinking to add ivabradine since my bp is not high and nebivolol will drive it lower, also hearing that it doesn't do much for GLP induced high RHR.
Should i start with one dose of 5mg or is it better to go straight to 5mg morning and evening? @FuriousAngus and anyone else using ivabradine I'd like some feedback.
In a perfect world I'd prefer to lower my RHR only while sleeping since it's in in the 70's and it messes my sleep big time, I'm getting like 10-15 minutes REM sleep each night. I wouldn't mind if the rest of day RHR stays higher for the sake of extra calorie burning but i think only metoprolol has such quite short halflife.
Bp is ok but RHR took a pretty big hit after increasing reta dose. I had a 7 points increase while on 1,5mg and after sometime at 6mg it went another 12+. Although i can't blame only reta for this, at the same time i increased the dose i added some low dose tren and probably this played some role too but i went from 67-70 to 88-90.
I have a week i reduced reta dose to 1,8mg per week since i couldn't stand the acid reflux and the bad digestion. Thankfully after only couple days no more waking in the middle of the night with puke in my mouth.
Now i want reduce rhr and I'm thinking to add ivabradine since my bp is not high and nebivolol will drive it lower, also hearing that it doesn't do much for GLP induced high RHR.
Should i start with one dose of 5mg or is it better to go straight to 5mg morning and evening? @FuriousAngus and anyone else using ivabradine I'd like some feedback.
In a perfect world I'd prefer to lower my RHR only while sleeping since it's in in the 70's and it messes my sleep big time, I'm getting like 10-15 minutes REM sleep each night. I wouldn't mind if the rest of day RHR stays higher for the sake of extra calorie burning but i think only metoprolol has such quite short halflife.
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I can relate to this, lol. Reta would’ve been perfect if it weren’t for this insane effect on RHR.
Iva has such a short half life that it really needs to be dosed twice a day for a stable reduction (in my experience); I do notice my RHR going up once I cross that 12 hour mark.
Start with 5mg x2/day and see how that goes. If needed, you can later pump further to 7.5mg (that’s the standard limit, it’s what I’m on).
Eddie.
Member
Ok, thanks man! I hope i can grab one later from the pharmacy and not have to wait sourcing it elsewhere. I'll start with 5mg x 2 and see how it goes.
Jesintn
Member
I ve smoked cannabis pre workout most days and even pre cardio which I do later. Mostly pre resistance , a bowl, small amount , usually I’ve done tirz competition prep last year . I’ve done sema to suppress appetite, after body fat was added. Didn’t notice one way or another. I have done about five preps now using a small amount of weed. Like caffeine , I try and not take it 6-8 hours pre sleep.
I know it’s best to cut back on cannabis with using any glp. Im thinking of using tirz maybe a month or so then sema a month. The food laying in the stomach is apparent, cannabis or no. I know thc works on the area of the brain that causes hunger . Has anyone mixed cannabis with sema, tirz or Reta, , and the glp mechanism definitely worked, or did weed cause any issues with these glp s and losing body fat?
I know it’s best to cut back on cannabis with using any glp. Im thinking of using tirz maybe a month or so then sema a month. The food laying in the stomach is apparent, cannabis or no. I know thc works on the area of the brain that causes hunger . Has anyone mixed cannabis with sema, tirz or Reta, , and the glp mechanism definitely worked, or did weed cause any issues with these glp s and losing body fat?
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