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[Ghoul]

Sorry to jump into this conversation with a slightly off-topic question.

Given you mentioned you are using Reta, which you expect is keeping your blood glucose in check when using your HGH dose…

How does a GLP-1 such as Tirz or Reta interact? Is there a synergistic effect and an advantage in running HGH alongside?

Also, between Tirz and Reta, does one work better alongside HGH than the other, or much the same?

All GLPs help offset the insulin resistance caused by GH.

When cells are exposed to long periods of high levels of insulin, which is produced to signal them to absorb extra glucose from blood, they respond by downregulating insulin receptor sensitivity, creating insulin resistance. They don't respond as well to the insulin signal, glucose in blood stays high.

GLPs make insulin producing cells function better. This means a quicker response to glucose spikes. Cells throughout the body are exposed to less "high insulin time". Over time., insulin receptors become more sensitive, and just a little insulin makes them pull glucose out of the blood fast, keeping glucose levels in check.

Reta is often preferred by BBs because the dose that gives this benefit doesn't cause much appetite suppression. Sema and Tirz provide the same benefit, but can come with appetite suppression that may be unwanted if you're not trying to lose weight.

 

[dcfreak]

Do we have an eta on the primo restock?

 

[ironmonkey]

All GLPs help offset the insulin resistance caused by GH.

When cells are exposed to long periods of high levels of insulin, which is produced to signal them to absorb extra glucose from blood, they respond by downregulating insulin receptor sensitivity, creating insulin resistance. They don't respond as well to the insulin signal, glucose in blood stays high.

GLPs make insulin producing cells function better. This means a quicker response to glucose spikes. Cells throughout the body are exposed to less "high insulin time". Over time., insulin receptors become more sensitive, and just a little insulin makes them pull glucose out of the blood fast, keeping glucose levels in check.

Reta is often preferred by BBs because the dose that gives this benefit doesn't cause much appetite suppression. Sema and Tirz provide the same benefit, but can come with appetite suppression that may be unwanted if you're not trying to lose weight.

Nice once thanks for this.

With this in mind, can serum IGF-1 blood levels be blunted when using HGH alongside a GLP-1?

 

[Ghoul]

Nice once thanks for this.

With this in mind, can serum IGF-1 blood levels be blunted when using HGH alongside a GLP-1?

This has been specifically studied and the answer is no. There's no clinically significant impact on IGF from GLPs.

 

[ironmonkey]

This has been specifically studied and the answer is no. There's no clinically significant impact on IGF from GLPs.

Ok thanks, out of interest do you happen to have a link to these studies ?

 

[sionnach]

Ok thanks, out of interest do you happen to have a link to these studies ?

Just google it bruh.

This has been specifically studied and the answer is no. There's no clinically significant impact on IGF from GLPs.

Bioglutide is gonna be a game changer here. It's oral (small molecule, not a peptide) and has activity at GLP-1, GIP, GCG, and IGF-1.

 

[Infernalmango]

Nice once thanks for this.

With this in mind, can serum IGF-1 blood levels be blunted when using HGH alongside a GLP-1?

I tested mine in late July. 480 igf1 levels on 3iu gh per night and 6mg reta in a once weekly injection.

 

[Mushy404]

I've noticed the Anavar, Dbol, Winstrol, pretty much all oral steroids are out of stock for a while. Have they said what the issue is, and when the ETA is for these to be back in stock?

 

[Jy108]

My rep Tansy’s email stopped working so I tried emailing Eve who referred me to Tansy and that email bounced back. Any rep email still working?

 

[aliikamz]

My friend (really my friend) took the time difference into account. He also wrote to Bella on Telegram – she replied there, but didn't answer his question. There has been no communication or response to any of his questions. Since the payment, emails can no longer be delivered, and contact is no longer good. Until the payment, contact with Bella was very good. My boyfriend is a bit worried now, as it's not normal for emails to no longer be delivered immediately after payment, and for the (previously good) contact to break off.

My reship arrived within a week of issuing. Bella was my rep and she took care of it pretty quickly.

But prior to that, it was a mission getting an answer. Ive ordered from different sources so I wasn't too concerned about the length of waiting but rather she couldn't actually give me a straight answer about asking the shipping company if they had any idea of it being seized by customs or if it was lost. The label was created for the original package but no waybill ever popped up. No waybill= never shipped. So after weeks of hassling she finally organised a reship and it arrived within a week. I still have no idea where the original package is or if it was even shipped. But I got all my stuff in the end.

 

[Yugo92]

Just google it bruh.


Bioglutide is gonna be a game changer here. It's oral (small molecule, not a peptide) and has activity at GLP-1, GIP, GCG, and IGF-1.

I have the impression that the more receptors are targeted, the less effective the action is on each individual receptor.
However, it also seems that it is not less potent than Tirz or Sema.

 

[sionnach]

I have the impression that the more receptors are targeted, the less effective the action is on each individual receptor.

On the surface of your statement, this is untrue (see chart of effect at each receptor site). But it could be true on a 1:1 molecule to receptor interaction, in which case you'd have to calculate moles per milligram.

 

[Ghoul]

On the surface of your statement, this is untrue (see chart of effect at each receptor site). But it could be true on a 1:1 molecule to receptor interaction, in which case you'd have to calculate moles per milligram.

It's true in the sense that GLPs like Tirz, and Reta artificially limit their protein chains to under 40 amino acids. (both 39).

In order to "fit" glucagon agonism into the same 39 amino size chain as Tirz, some potency had to be sacrificed on GLP.

It's done because over 40 aminos becomes a "biologic" class drug, with much stricter FDA regulation and less protection from competition.

 

[Arnie1]

My rep Tansy’s email stopped working so I tried emailing Eve who referred me to Tansy and that email bounced back. Any rep email still working?

Immediately after the payment, my friend was no longer able to send emails to Bella. So he contacted her on Telegram. However, he only gets meaningless, nonsensical answers, and questions aren't answered. What's going on with @SigmaAudley China Peptide Do you have a problem with emails in general? But why are there no proper replies on Telegram after the payment?

 

[dcfreak]

Immediately after the payment, my friend was no longer able to send emails to Bella. So he contacted her on Telegram. However, he only gets meaningless, nonsensical answers, and questions aren't answered. What's going on with @? Do you have a problem with emails in general? But why are there no proper replies on Telegram after the payment?

WhatsApp will probably be your best bet for communication

 

[pengpent]

@SigmaAudley China Peptide the variability is a bit high here?

Janoshik Analytical

 

[pengpent]

I've noticed the Anavar, Dbol, Winstrol, pretty much all oral steroids are out of stock for a while. Have they said what the issue is, and when the ETA is for these to be back in stock?

Most chinese vendors have been struggling to get raws since a few months. AFAIK there is no ETA when it will be back to normal.

 

[Sera]

Immediately after the payment, my friend was no longer able to send emails to Bella. So he contacted her on Telegram. However, he only gets meaningless, nonsensical answers, and questions aren't answered. What's going on with @SigmaAudley China Peptide Do you have a problem with emails in general? But why are there no proper replies on Telegram after the payment?

Message a different rep, maybe Ada

 

[Arnie1]

WhatsApp will probably be your best bet for communication

Unfortunately not! There was a short reply, then nothing more. No answer to the question – nothing! And why are emails no longer delivered immediately after payment? Strange – I also thought there might be a problem with emails, but if messages are read on Telegram and not responded to, that's odd or doesn't make a good impression – even if the friend isn't worried yet and it's not a large order, it's just a shame not to have any further contact after payment and to be ignored.

 

[aliikamz]

Unfortunately not! There was a short reply, then nothing more. No answer to the question – nothing! And why are emails no longer delivered immediately after payment? Strange – I also thought there might be a problem with emails, but if messages are read on Telegram and not responded to, that's odd or doesn't make a good impression – even if the friend isn't worried yet and it's not a large order, it's just a shame not to have any further contact after payment and to be ignored.

Just give a bit. Bella can be slack but she doesn't reply eventually.