Reta Microdosing (<1.5mg) to improve lipids?

[Banana Joe]

I had already asked here, but it sadly didn't get any replies.

How many of you guys are taking microdoses of Reta (<1.5mg?) mainly to improve HDL/LDL?
I have seen quite a few people on YT making similar claims, but Big Paul is the first one that provided actual numbers.

Other benefits should be:
- improved insulin sensitivity (might be even a given)
- reduced visceral and liver fat via glucagon receptor signaling


I always had bad HDL/LDL (hereditary) and have started taking 0.2mg e2d of Reta just recently. So far I feel no reduction in appetite, which is critical for me, as I have become a terrible eater over the years. If I feel no ill effects, I might up the dose to 0.3mg e2d.
Haven't gotten a new blood panel as my diet is a bit terrible atm, and I need to fix that first to get any meaningful data.

 

[Yugo92]

Not gonna work bro. Studies say so.

After a bad experience with semaglutide, I switched to tirzepatide and decided to titrate slowly, starting with just 0.5 mg for two weeks, then 1 mg for another two weeks.
Whether it was psychological or not, I did feel some appetite suppression even at those micro doses.
I then moved up to 2.5 mg, combined with electrolytes and a vitamin cocktail.
No side effects at all, and excellent appetite suppression with just 2.5 mg!

 

[RockyP]

After a bad experience with semaglutide, I switched to tirzepatide and decided to titrate slowly, starting with just 0.5 mg for two weeks, then 1 mg for another two weeks.
Whether it was psychological or not, I did feel some appetite suppression even at those micro doses.
I then moved up to 2.5 mg, combined with electrolytes and a vitamin cocktail.
No side effects at all, and excellent appetite suppression with just 2.5 mg!

I have also tolerated Tirz very well. I'm a sucker and paying for it from the doc / Lilly. took the 2.5 mg all at once as prescribed. Started splitting the dose to 2.5 twice per week once I got to the 5 mg. No side effects whatsoever. The appetite suppression does start to dip a little towards the end of the week if you are doing once weekly shots. I also think as the dosage goes up it might be harder to tolerate once weekly. I'm 99.99% sure that these recommendations are for compliance in the general population. I think twice weekly (or more, depending on your personal tolerance to any of these) is the best way to mitigate side effects.

 

[The Answ3r]

PTVS DUO for Pita 4mg/Eze 10mg

View attachment 337550

I pay $4/strip of 10.

PTVS PLUS is Pita 2mg/Eze 10mg

View attachment 337552

I’ve noticed you often recommend Pitavastatin. From what I understand, it’s easier on the liver than rosuvastatin and may have a slightly better effect on insulin sensitivity. Do you think it makes sense to switch if I’m having zero issues with rosuvastatin at 5 or 10 mg daily, and I’m also running Bempesta EZ in the background? I don’t have any liver or insulin‑related problems, so I’m wondering if there’s really an advantage for me or if it’s more for people who struggle with side effects.

 

[Ghoul]

I’ve noticed you often recommend Pitavastatin. From what I understand, it’s easier on the liver than rosuvastatin and may have a slightly better effect on insulin sensitivity. Do you think it makes sense to switch if I’m having zero issues with rosuvastatin at 5 or 10 mg daily, and I’m also running Bempesta EZ in the background? I don’t have any liver or insulin‑related problems, so I’m wondering if there’s really an advantage for me or if it’s more for people who struggle with side effects.

Generally my position is If it ain't broke don't fix it. The fact you're on a statin you're not having any issues with and crushing LDL is already a huge, unquestionable advantage for your long term health putting you in a tiny minority of people, I wouldn't fuck with that success.

Obviously if sides ever develop you should switch rather than stop lipid lowering therapy.

One thing to be on the lookout for are insulin resistance issues, like with rHGH use, which can grow (but still very rare) with long term use of every statin EXCEPT Pitavaststin, which improves insulin resistance. (or at worst, has no effect on it).

Liver enzymes might be another reason to switch. Every statin except Pita is metabolized by CYP450. A ton of drugs use the same liver enzyme, and it could raise ALT/AST. Pita avoids almost all issues of interaction with other drugs because it's metabolized completely differently.

I mainly recommend Pita as an option for statin traumatized (real or imagined) guys like me. It dodges almost all the reasons people have to avoid statins. Frankly, they keep finding more and more benefits, like signals that it may slow cancer development. I have a rare skin condition called DSAP that I've lived with for 15 years that it seems to have cleared up.

For pro athletes that have high lipids, it's been the go to statin for years since its $500/mo former price was considered worth avoiding any real possibility of issues impacting physical performance.



The only reason I'm not using Bempedoic acid is I already have side effect free 90%+ LDL reduction with Pita, Ezetimebe, and Repatha (LDL is 20-25), and for the very long term, Bemp might slow collagen turnover, possibly weakening tendons (though problems have been exceedingly rare and affecting those over 80).

 

[The Answ3r]

Generally my position is If it ain't broke don't fix it. The fact you're on a statin you're not having any issues with and crushing LDL is already a huge, unquestionable advantage for your long term health putting you in a tiny minority of people, I wouldn't fuck with that success.

Obviously if sides ever develop you should switch rather than stop lipid lowering therapy.

One thing to be on the lookout for are insulin resistance issues, like with rHGH use, which can grow (but still very rare) with long term use of every statin EXCEPT Pitavaststin, which improves insulin resistance. (or at worst, has no effect on it).

Liver enzymes might be another reason to switch. Every statin except Pita is metabolized by CYP450. A ton of drugs use the same liver enzyme, and it could raise ALT/AST. Pita avoids almost all issues of interaction with other drugs because it's metabolized completely differently.

I mainly recommend Pita as an option for statin traumatized (real or imagined) guys like me. It dodges almost all the reasons people have to avoid statins. Frankly, they keep finding more and more benefits, like signals that it may slow cancer development. I have a rare skin condition called DSAP that I've lived with for 15 years that it seems to have cleared up.

For pro athletes that have high lipids, it's been the go to statin for years since its $500/mo former price was considered worth avoiding any real possibility of issues impacting physical performance.

View attachment 339568

The only reason I'm not using Bempedoic acid is I already have side effect free 90%+ LDL reduction with Pita, Ezetimebe, and Repatha (LDL is 20-25), and for the very long term, Bemp might slow collagen turnover, possibly weakening tendons (though problems have been exceedingly rare and affecting those over 80).

Thanks for the detailed and clear breakdown. I’ll stick with rosuvastatin for now since it’s working well, but might consider switching to Pitavastatin down the line.

 

[RockyP]

Thanks for the detailed and clear breakdown. I’ll stick with rosuvastatin for now since it’s working well, but might consider switching to Pitavastatin down the line.

FWIW I was on rosuva 5 mg with LDL of 65. Upped it to 10 mg to try to get LdL in the 50’s or lower since my HDL runs low. I just a few days ago started pita 2 mg. Will be pulling bloods in 4 to 6 weeks. If LdL is at least the same or better, and if HDL bumps up a bit, I’ll remain on Pita. Can also bump to 4 mg and add zetia for virtually side effect free further lipid lowering. Worse case scenario I go back to rosuva and aim for an LDL in the 50’s. My diet / lifestyle is pristine, though I did just throw some primo into my regimen. We’ll see.

 

[Nunya]

Generally my position is If it ain't broke don't fix it. The fact you're on a statin you're not having any issues with and crushing LDL is already a huge, unquestionable advantage for your long term health putting you in a tiny minority of people, I wouldn't fuck with that success.

Obviously if sides ever develop you should switch rather than stop lipid lowering therapy.

One thing to be on the lookout for are insulin resistance issues, like with rHGH use, which can grow (but still very rare) with long term use of every statin EXCEPT Pitavaststin, which improves insulin resistance. (or at worst, has no effect on it).

Liver enzymes might be another reason to switch. Every statin except Pita is metabolized by CYP450. A ton of drugs use the same liver enzyme, and it could raise ALT/AST. Pita avoids almost all issues of interaction with other drugs because it's metabolized completely differently.

I mainly recommend Pita as an option for statin traumatized (real or imagined) guys like me. It dodges almost all the reasons people have to avoid statins. Frankly, they keep finding more and more benefits, like signals that it may slow cancer development. I have a rare skin condition called DSAP that I've lived with for 15 years that it seems to have cleared up.

For pro athletes that have high lipids, it's been the go to statin for years since its $500/mo former price was considered worth avoiding any real possibility of issues impacting physical performance.

View attachment 339568

The only reason I'm not using Bempedoic acid is I already have side effect free 90%+ LDL reduction with Pita, Ezetimebe, and Repatha (LDL is 20-25), and for the very long term, Bemp might slow collagen turnover, possibly weakening tendons (though problems have been exceedingly rare and affecting those over 80).

Had a Ca score this week, not great results, guessing next step will be a statin, thanks for all this info. I’ll push for the good one, I’m clearly an athlete :/

 

[eryximachus]

Even if you could benefit from the lipid improvement of max dose Reta, it won't come anywhere close to what Pitavastatin, Ezetimebe. Bempedoic Acid. and/OR a PCSK9 inhibitor would do.

If you're in the US and have familial hypercholestoremia you could probably qualify for Repatha and demolish lipids with one injector pen shot a month.

Can we get any Chinese manufacturers to give us Repatha?

 

[eryximachus]

In the meantime we've got new GLP/Muscle sparing combos around the corner.

We do? Like what?

 

[eryximachus]

The only reason I'm not using Bempedoic acid is I already have side effect free 90%+ LDL reduction with Pita, Ezetimebe, and Repatha (LDL is 20-25), and for the very long term, Bemp might slow collagen turnover, possibly weakening tendons (though problems have been exceedingly rare and affecting those over 80).

Where do you buy Pita? None of my Indians seem to sell it. And Repatha...

 

[Ghoul]

We do? Like what?

Eli Lilly's Bimagrumab about to enter final trials prior to approval. Not only muscle sparing, demonstrated muscle mass increase while losing weight.

New GLP-1 Therapies Enhance Quality of Weight Loss by Improving Muscle Preservation | American Diabetes Association

Findings from two groundbreaking studies highlight potential pharmacological and biosensor solutions for muscle mass preservation in patients undergoing obesity treatment therapy.

diabetes.org

 

[wp_375]

Eli Lilly's Bimagrumab about to enter final trials prior to approval. Not only muscle sparing, demonstrated muscle mass increase while losing weight.

New GLP-1 Therapies Enhance Quality of Weight Loss by Improving Muscle Preservation | American Diabetes Association

Findings from two groundbreaking studies highlight potential pharmacological and biosensor solutions for muscle mass preservation in patients undergoing obesity treatment therapy.

diabetes.org

Not seeing that one at a Chinese UGL any time soon...

 

[eryximachus]

Not seeing that one at a Chinese UGL any time soon...

It's pretty clear China doesn't give a F about patents.

This is the real reason there is a crackdown on Chinese drugs. They don't really give a shit about the relatively few people OD on fentanyl.

 

[wp_375]

It's pretty clear China doesn't give a F about patents.

This is the real reason there is a crackdown on Chinese drugs. They don't really give a shit about the relatively few people OD on fentanyl.

It's nothing to do with that and everything to do with the drug being a monoclonal antibody which is cutting edge tech regular drug production facilities in China that make peptides and what not don't have the capability to manufacture.

 

[CHIEF M]

For anyone interested, I know one host is bit controversial (...), but I find the other two of them to provide good insights and good info on most subjects:


View: https://www.youtube.com/watch?v=7SITjXMtR8E&t=2627s



View: https://www.youtube.com/watch?v=a8BIVNPqPro


PS: WTF - SSA now selling 50mg vials of Reta? That currently is more than a year's worth of Reta for me in single vial!
How much Reta are some fat people actually taking???

Have to up the dose

 

[Banana Joe]

For anyone interested or wanting to hate on me more, LOL:

I went to see a cardiologist yesterday, and after looking at me in general, reviewing my bloodwork, checking my arteries (100% clear) etc. he was not worried about my high-ish LDL (or low HDL), even considering my family history.
He said I could take a LDL lowering drug for preventive measures, but also that he would not urge me to do it.

He even said outright he did not expect me to have that blood pressure (131/80*) based on how I look. I guess I should take that as compliment...


I think I am gonna get on something but I am unsure which drug(-s). I am worried any statin will give me muscle pain. I am in enough pain already, due to all my injuries, I really don't want to be in just a tiny bit more.
Maybe Ezemtib and bempedoic acid will suffice? I guess it is worth a try, even though I am a bit sceptic myself. If I am gonna take one or two of these drugs, I want to get LDL below 100.

*which is rather high for me, usually I am in the 120s. But I rode there with my bike not too long before they measured it.

 

[Ghoul]

For anyone interested or wanting to hate on me more, LOL:

I went to see a cardiologist yesterday, and after looking at me in general, reviewing my bloodwork, checking my arteries (100% clear) etc. he was not worried about my high-ish LDL (or low HDL), even considering my family history.
He said I could take a LDL lowering drug for preventive measures, but also that he would not urge me to do it.

He even said outright he did not expect me to have that blood pressure (131/80*) based on how I look. I guess I should take that as compliment...


I think I am gonna get on something but I am unsure which drug(-s). I am worried any statin will give me muscle pain. I am in enough pain already, due to all my injuries, I really don't want to be in just a tiny bit more.
Maybe Ezemtib and bempedoic acid will suffice? I guess it is worth a try, even though I am a bit sceptic myself. If I am gonna take one or two of these drugs, I want to get LDL below 100.

*which is rather high for me, usually I am in the 120s. But I rode there with my bike not too long before they measured it.

Neither Ezetimebe or Bempodoic acid is likely to cause sides. Neither has anything to do with the way statins work, they're completely different, so don't let psychosomatic "statinphobia" make your muscles start to hurt after you start using them, lol.

Most primary care doctors don't care about your longevity, and stopped keeping up with current knowledge shortly after graduating medical school. To most, it's a job and they do the bare minimum.

A preventative cardiologist would be far more proactive and consider your long term health in ways most PCPs just don't give a shit about.

 

[Ruru_Teh_seks]

The last time I saw my doctor for a blood test, I told him it was related to illicit products. He asked me if I was taking creatine. I said yes. He told me "that's very dangerous, illicit things aren't important." I wanted to scream. I never went to see him again.

 

[ChemBB]

The only reason I'm not using Bempedoic acid is I already have side effect free 90%+ LDL reduction with Pita, Ezetimebe, and Repatha

You're taking all 3 of Pita, Ezetimibe, and Repatha?

Here are my lipids and some related markers on below stack, in case anyone is curious. There's no stopping Winstrol, I guess.

- 400/250/250 Test/Tren/Mast
- 50 Winstrol (4 weeks)
- 6iu GH
- 10mg Cardarine
- 8mg Reta

 

[Ghoul]

You're taking all 3 of Pita, Ezetimibe, and Repatha?

Here are my lipids and some related markers on below stack, in case anyone is curious. There's no stopping Winstrol, I guess.

- 400/250/250 Test/Tren/Mast
- 50 Winstrol (4 weeks)
- 6iu GH
- 10mg Cardarine
- 8mg Reta

View attachment 348913

4mg of Pita. if that's what you're asking.

Those lipids aren't that bad on gear. Either Pita or a combo of Eze and Bemp would get you into the reasonably safe sub 70 LDL range.