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[Ghoul]

Have you seen this in the news recently? Looks like a more affordable PCSK9 product. And should be easier to get approved for.

Leqvio's Game-Changing Potential in Cardiovascular Therapeutics and Its Implications for Novartis' Growth Trajectory

Leqvio's Game-Changing Potential in Cardiovascular Therapeutics and Its Implications for Novartis' Growth Trajectory

www.ainvest.com

If you mean Leqvio, it's been available for a little while in the US. Its main advantage is 2x shots a year vs Repatha every 2 weeks. But, it has to be done in doctors office, and reduces LDL by 50% vs Repatha 60%.

Also, because Repatha is older, despite its $7,000 list price, they've been making it available very inexpensively to insurance companies that agree to lower the pre-approval requirements.

I use Repatha, Pitavastatin 4mg, and Ezetimebe. Dropped LDL from 160 to 32, HDL increased from 40 to 53.

Finally, most important for anyone in the US, literally just a few days ago, the FDA authorized Repatha for anyone with LDL above 100 and another risk factor, like high blood pressure.

It's very easy for most people with insurance to get it now.

If anyone's interested. I'll write up the "script" you'll need to follow to get it. (you have to get around the "try a $5/mo statin first" most insurance cos still require. )

 

[Tkjo]

If you mean Leqvio, it's been available for a little while in the US. Its main advantage is 2x shots a year vs Repatha every 2 weeks. But, it has to be done in doctors office, and reduces LDL by 50% vs Repatha 60%.

Also, because Repatha is older, despite its $7,000 list price, they've been making it available very inexpensively to insurance companies that agree to lower the pre-approval requirements.

I use Repatha, Pitavastatin 4mg, and Ezetimebe. Dropped LDL from 160 to 32, HDL increased from 40 to 53.

Finally, most important for anyone in the US, literally just a few days ago, the FDA authorized Repatha for anyone with LDL above 100 and another risk factor, like high blood pressure.

It's very easy for most people with insurance to get it now.

If anyone's interested. I'll write up the "script" you'll need to follow to get it. (you have to get around the "try a $5/mo statin first" most insurance cos still require. )

Man, thank you for always hitting the nail on the freaking head. Sending you a DM.

 

[newguy2]

If you mean Leqvio, it's been available for a little while in the US. Its main advantage is 2x shots a year vs Repatha every 2 weeks. But, it has to be done in doctors office, and reduces LDL by 50% vs Repatha 60%.

Also, because Repatha is older, despite its $7,000 list price, they've been making it available very inexpensively to insurance companies that agree to lower the pre-approval requirements.

I use Repatha, Pitavastatin 4mg, and Ezetimebe. Dropped LDL from 160 to 32, HDL increased from 40 to 53.

Finally, most important for anyone in the US, literally just a few days ago, the FDA authorized Repatha for anyone with LDL above 100 and another risk factor, like high blood pressure.

It's very easy for most people with insurance to get it now.

If anyone's interested. I'll write up the "script" you'll need to follow to get it. (you have to get around the "try a $5/mo statin first" most insurance cos still require. )

Curious what's the usual go to $5 a month statin they want to put you on?

I just got hooked up with a PCP and am trying to get my cholesterol sorted.

 

[BamaCrazy]

Curious what's the usual go to $5 a month statin they want to put you on?

I just got hooked up with a PCP and am trying to get my cholesterol sorted.

Rosuvastatin is the fan favorite. It’s the first drug doctors will recommend for high cholesterol. It’s cheaper than Pitavastatin so even if there are better options they will still recommend Rosuvastatin

 

[newguy2]

Rosuvastatin is the fan favorite. It’s the first drug doctors will recommend for high cholesterol. It’s cheaper than Pitavastatin so even if there are better options they will still recommend Rosuvastatin

And it seems like pitavastatin is more recommended here?

 

[Ghoul]

Curious what's the usual go to $5 a month statin they want to put you on?

I just got hooked up with a PCP and am trying to get my cholesterol sorted.

Rosuvastatin is the most commonly prescribed now. It's effective, potent, cheap, fewer sides than older statins, but still carries a significantly higher risk of sides than Pitavastatin, worsens insulin resistance, impairs muscle mitochondria, and can penetrate muscle causing pain (fairly rare, but certain people are sensitive to this effect, and the doctors will be familiar with this statin induced side effect. It used to be VERY common with older statins, each generation has lessened it. Pitavastatin has, for all intents, eliminated it.). IMO the worst aspect of Rosuvastatin is the longer you take it, the higher your risk of developing diabetes is. That's not acceptable for a lifetime maintainance medication imo. Pitavastatin IMPROVES insulin sensitivity, actually reducing the risk of diabetes.

To be fair most people do well on Rosuvastatin, but if you have any sway try to get Pitavastatin. Mention you're athletic and concerned about impact on muscles. Don't be too surprised if they're unfamiliar
with it.

If no luck, accept Rosuvastatin, then a week or so later call the doctors office to report "muscle aches" when working out (especially in legs). They may try different doses or even switch you to another statin. Repeat the complaint a week layer with "it's intolerable".

At that point they should be willing to switch you to Pitavaststin.



Ezetimebe is usually offered as well. That's essentially side effect free and combined with statins to increase LDL reduction.

 

[Photon]

If you mean Leqvio, it's been available for a little while in the US. Its main advantage is 2x shots a year vs Repatha every 2 weeks. But, it has to be done in doctors office, and reduces LDL by 50% vs Repatha 60%.

Also, because Repatha is older, despite its $7,000 list price, they've been making it available very inexpensively to insurance companies that agree to lower the pre-approval requirements.

I use Repatha, Pitavastatin 4mg, and Ezetimebe. Dropped LDL from 160 to 32, HDL increased from 40 to 53.

Finally, most important for anyone in the US, literally just a few days ago, the FDA authorized Repatha for anyone with LDL above 100 and another risk factor, like high blood pressure.

It's very easy for most people with insurance to get it now.

If anyone's interested. I'll write up the "script" you'll need to follow to get it. (you have to get around the "try a $5/mo statin first" most insurance cos still require. )

My insurance waived all repatha requirements at the start of the year. No p.a, statin requirement etc. Getting it prescribed via telemed was easy but I ultimately ended up going to a cardiologist because those teledoctors wouldnt give me 1 year worth of refills.

For those interested, check with your insurance first. If there's no requirements, you can get it easily via telemed.

If paying out of pocket, praluent is a much cheaper option.

 

[BamaCrazy]

My insurance waived all repatha requirements at the start of the year. No p.a, statin requirement etc. Getting it prescribed via telemed was easy but I ultimately ended up going to a cardiologist because those teledoctors wouldnt give me 1 year worth of refills.

For those interested, check with your insurance first. If there's no requirements, you can get it easily via telemed.

If paying out of pocket, praluent is a much cheaper option.

I just looked and TriCare has now made it slightly easier. If a cardiologist prescribes it no PA is necessary. But if your Primary Care doc prescribes it you do.

 

[AlexDavis43]

Why would it have a higher risk because of that?

True. Me of all people should know this. I waited 3 weeks for Reta to clear my system. I cannot imagine having a reaction to Leqvio and waiting 6 months for it to clear.

Exactly

If you don't like this drug for whatever reason, get ready to embrace the suck cuz you're gonna have 6 months of it

I have the same reservations about the monthly GLP1s in development

 

[Tkjo]

Exactly

If you don't like this drug for whatever reason, get ready to embrace the suck cuz you're gonna have 6 months of it

I have the same reservations about the monthly GLP1s in development

Ah yeah, I hadn’t thought of it going wrong. That’s the longest half life I’ve ever seen.

 

[Tkjo]

Anybody familiar with finding drug coverage info for Kaiser HMO plans? It’s been harder to work with an HMO network ever since switching.

 

[Ghoul]

Anybody familiar with finding drug coverage info for Kaiser HMO plans? It’s been harder to work with an HMO network ever since switching.

Drug formulary | Kaiser Permanente

Our formulary lists the drugs covered by your health plan. Medical professionals use it to choose the best drugs for you. See the formulary for your plan.

healthy.kaiserpermanente.org

 

[explodingHeart]

Rosuvastatin is the most commonly prescribed now. It's effective, potent, cheap, fewer sides than older statins, but still carries a significantly higher risk of sides than Pitavastatin, worsens insulin resistance, impairs muscle mitochondria, and can penetrate muscle causing pain (fairly rare, but certain people are sensitive to this effect, and the doctors will be familiar with this statin induced side effect. It used to be VERY common with older statins, each generation has lessened it. Pitavastatin has, for all intents, eliminated it.). IMO the worst aspect of Rosuvastatin is the longer you take it, the higher your risk of developing diabetes is. That's not acceptable for a lifetime maintainance medication imo. Pitavastatin IMPROVES insulin sensitivity, actually reducing the risk of diabetes.

To be fair most people do well on Rosuvastatin, but if you have any sway try to get Pitavastatin. Mention you're athletic and concerned about impact on muscles. Don't be too surprised if they're unfamiliar
with it.

If no luck, accept Rosuvastatin, then a week or so later call the doctors office to report "muscle aches" when working out (especially in legs). They may try different doses or even switch you to another statin. Repeat the complaint a week layer with "it's intolerable".

At that point they should be willing to switch you to Pitavaststin.

View attachment 344791

Ezetimebe is usually offered as well. That's essentially side effect free and combined with statins to increase LDL reduction.

Thoughts on 5mg Rosouva every other day?

I have genetically low LDL (30s no statin and on gear). Even my obese dad has a 60 LDL/70s HDL drug free on his RFK/Carnivore grifter butter diet. But I take it Rosouva to protect myself while on gear and I guess I'll keep taking it on a more sane TRT dose.

 

[Ghoul]

Thoughts on 5mg Rosouva every other day?

I have genetically low LDL (30s no statin and on gear). Even my obese dad has a 60 LDL/70s HDL drug free on his RFK/Carnivore grifter butter diet. But I take it Rosouva to protect myself while on gear and I guess I'll keep taking it on a more sane TRT dose.

I can't think of any benefit you'd get by using a statin with LDL that low. If it's been that low your entire life you have near zero risk of cardiovascular disease. The pleiotropic effects, even of Pitavastatin are inconsequential when LDL is that low. I'd drop it and focus on other aspects of your health. Like blood pressure, inflammation, insulin sensitivity.

 

[Yura(HYB)]

The latest HYB price list has been updated, with price reductions on certain peptides and the addition of new peptide products.

https://privatebin.net/?23c36347f3c104c5#Et8saiPDHoBE1Qkxa9CM6CTeqds2EmVivJDwUTbcJReR

 

[ddauria88]

Has anybody used HYBs EQ?

 

[Photon]

Has anybody used HYBs EQ?

They just restocked and it sold out..
I'm just waiting to see if it tests the same as SSA.

 

[PsychedUp]

Does anyone have used the Hyb reta 20? Been using it for a while, but don't notice that much of an effect... There is no labreport, so that's why I'm curious about other people's experiences.

On it and taking 3.5mg weekly, has definitely had a noticeable effect on my appetite and cravings.

 

[explodingHeart]

I can't think of any benefit you'd get by using a statin with LDL that low. If it's been that low your entire life you have near zero risk of cardiovascular disease. The pleiotropic effects, even of Pitavastatin are inconsequential when LDL is that low. I'd drop it and focus on other aspects of your health. Like blood pressure, inflammation, insulin sensitivity.

I suppose the last problem is kidney health.

Being on gear and HGH shoots my cystatin c from .7 to .85. I think it's mainly the GH causing kidney strain.

Or if I'm dead set on blasting gear again, just stick with like 1g test and a low dose of GH, or none at all. Not worth the extra kidney strain as high dose anabolics seem relatively benign.

 

[bananafeet]

I suppose the last problem is kidney health.

Being on gear and HGH shoots my cystatin c from .7 to .85. I think it's mainly the GH causing kidney strain.

Or if I'm dead set on blasting gear again, just stick with like 1g test and a low dose of GH, or none at all. Not worth the extra kidney strain as high dose anabolics seem relatively benign.

What would you consider a "low dose" of HGH?