MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Is the superior insulin sensitivity at equivalent dosages? I only need 2.5mg tirz for some reason and I've been super obese in the past.
Doesn't Reta make your muscles more flat than Tirz?
Last edited:
Ghoul
Member
I don't think it's an issue to modulate the dose up or down. That happens to natural GLP / GIP levels. Just keep in mind after any change it takes 4 weeks to reach stable blood levels. By the end of the 2nd week of the new dose it's 80% of the 4 week level, so you'll have an idea if it's too much or too little. IMO stopping than restarting months latter could be a problem.
Liter O' Test
Member
talked to my hair stylist about GLPS.. found out she tried tirzepetide.
told me she was on like 12.5mg and it stopped working
she later sent me the script, it was a 17mg/ml tirz vial mixed with carnitine
script said to use 12.5 units.
paid out the ass for like 2mg a week of a microdose injection volume in a vial that would hang in the fridge for like 2 months
no wonder it stopped working, not having the patient increase like pharma, probably upcharged her for the 1g carnitine too
told me she was on like 12.5mg and it stopped working
she later sent me the script, it was a 17mg/ml tirz vial mixed with carnitine
script said to use 12.5 units.
paid out the ass for like 2mg a week of a microdose injection volume in a vial that would hang in the fridge for like 2 months
no wonder it stopped working, not having the patient increase like pharma, probably upcharged her for the 1g carnitine too
Novo's Wegovy Cuts Cardio Risk by 57% Versus Tirzepatide
Novo Nordisk’s Wegovy has been on a winning streak as of late, with a metabolic dysfunction-associated steatohepatitis approval last month and prime position in the oral obesity race.
www.biospace.com
Ghoul
Member
Novo's Wegovy Cuts Cardio Risk by 57% Versus Tirzepatide
Novo Nordisk’s Wegovy has been on a winning streak as of late, with a metabolic dysfunction-associated steatohepatitis approval last month and prime position in the oral obesity race.
Very weak study for this type of thing. You need thousands, at the least, not 100 people, and follow up has to be years, now a few months. In this case the study seems more like marketing than any substantial revelation.
Back from vacation and figured I’d drop a quick Tirz update. Hit my standard 15 mg dose before the flight out. First week went smooth, no issues. Second week was interesting though, it felt like the effect actually kicked in harder, appetite was basically gone. Ended up missing a good chunk of protein but somehow still managed to put away a decent amount of sweets (nothing too crazy). Net result was minus 2 kg (about 4.4 lbs).
So for anyone worried that missing a week will ruin the effect or cause something weird, don’t stress, nothing bad happens. Today I dropped the dose from 15 mg down to 10 mg, so we’ll see how it goes from here.
So for anyone worried that missing a week will ruin the effect or cause something weird, don’t stress, nothing bad happens. Today I dropped the dose from 15 mg down to 10 mg, so we’ll see how it goes from here.
This might be a little off-topic but I didn’t want to start a new thread. @Ghoul, you once mentioned that GLP-1 had been studied in cats, right? Were there specific “GLP-1” type drugs used? I took my cat in for labs today and he was diagnosed with diabetes. For now, they suggested either insulin or some of the newer drugs like Bexacat or Senvelgo. I just want to ask the vet about GLP-1 as an option, if that’s even possible of course.
Jesintn
Member
One of cats i cared for passed and we had to give insulin shots. The glp dose would be lower. If the vet doesn’t jump on board or keep up with the science, you could self administer a cat micro dose. The doctors simply tell you they are expiriemwnring anyways. I would imagine quite a few of us are more up to date and intelligent than some vets. It is a job though for your cats health
I think it’s a good idea for cats with diabetes. That said too much can and will cause it to not eat and lose too much weight. Look what happened to Sharon Osborne, after she was on a glp for nine months
I'm interested in the literature for 8-12mg. I've seen people state 4mg-8mg but haven't been able to find anything to read up on what it's based on.
Has anyoene else experienced that their Tirzepatide or other GLP1 feels more powerfull when more diluted? Some time ago I was going trough some 5mg vials (seller sent me the wrong size vials), so I was doing 2 whole vials every injection (10ml). using 1ml for each vial so I was injecting 2ml each time. Then I got the 40mg ones and so I was diluting to 0.5ml per 10mg dose, and it felt less potent (tho I assumed it was just me loosing weight maybe). Then I tried reconstituting the same 40mg vials @1ml per 10mg injection and it's been feeling stronger. I'll try to dilute the next vial at 2ml/10mg and see if I get a even better effect (I'll have to get some sterile vials tho becaise the Tirz vial only holds 3ml)
Ghoul
Member
You're exposing the peptide to more vascular area, speeding up the time to reach plasma peak, vs the typical 48 hour absorption at .5ml, so you "feel" the sides as being stronger.
2ml will absorb even faster, because you're stretching subQ tissue like a balloon, and the liquid will be under pressure.
But total exposure is ultimately still the same because of the long half life.
Ghoul
Member
Hell of a memory bro! I did, and forgot about it.
Shockingly, despite a dozen papers on GLPs and pets, still nothing about sema or tirz, and therefore no info on dose.
Only Exanatide (daily),dosing info.
bananafeet
Member
3 week mark on Mazdutide.
Currently on 6mg per week. I am starting to get decent appetite suppression now. It's quite different to semaglutide appetite suppression which is a locked down stomach feeling. It's like I have an inhibition to eat. My stomach is definitely effected but it's not like semaglutide.
Interesting stuff. Also different to tirzepatide which didn't effect my stomach as much but mentally seemed to disincentivise me. I don't seem to be getting the same fatigue issues with mazdutide as I did with tirzepatide. However I've been battling a flu lately and my diet has been very poor.
As for blood sugar control I think it's great. Before I started I did 100g of glucose based lollies and checked my blood sugar 30 mins later which got to 8.2mmol.
Did the same thing yesterday on mazdutide and I got to 6.1mmol. My fasting glucose seems fine around 4.8mmol.
Current stack is 125mg/week test E, 100mg/week nandralone and 2iu HGH per day.
Heart effects have been fine. I have dropped my metoprolol succinate dose to 25mg and only have 12.5mg metoprolol tartrate before bed. Pretty much half what I was taking on Retatrutide to calm my heart. Maybe I am used to the glucagon effect?
Resting heart rate (over night) is up 2 bpm from 60.
So far so good. Currently 108kg on the dot. Should be going down from here.
Currently on 6mg per week. I am starting to get decent appetite suppression now. It's quite different to semaglutide appetite suppression which is a locked down stomach feeling. It's like I have an inhibition to eat. My stomach is definitely effected but it's not like semaglutide.
Interesting stuff. Also different to tirzepatide which didn't effect my stomach as much but mentally seemed to disincentivise me. I don't seem to be getting the same fatigue issues with mazdutide as I did with tirzepatide. However I've been battling a flu lately and my diet has been very poor.
As for blood sugar control I think it's great. Before I started I did 100g of glucose based lollies and checked my blood sugar 30 mins later which got to 8.2mmol.
Did the same thing yesterday on mazdutide and I got to 6.1mmol. My fasting glucose seems fine around 4.8mmol.
Current stack is 125mg/week test E, 100mg/week nandralone and 2iu HGH per day.
Heart effects have been fine. I have dropped my metoprolol succinate dose to 25mg and only have 12.5mg metoprolol tartrate before bed. Pretty much half what I was taking on Retatrutide to calm my heart. Maybe I am used to the glucagon effect?
Resting heart rate (over night) is up 2 bpm from 60.
So far so good. Currently 108kg on the dot. Should be going down from here.
good on you mate. Glad you found something that's working for you.
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