Peptide that is close to botox?

[Ghoul]

Interesting! Thanks for the info. By the way, with that cumulative dose, besides acne clearing up, did you notice any other improvements in your skin? Like fewer wrinkles, more even skin tone, smaller pores, stuff like that?

It was a significant improvement in skin quality. Nose literally shrunk as well.

 

[june43]

A meta study found the highest chances of never requiring a 2nd course treatment correlated with two factors: cumulative doses of at least 220mg/kg and continuing to take isotretinoin at least 51 days after full acne clearance.

The higher cumulative dose is especially important for permanently eliminating trunk acne, vs facial acne which can be handled with lower cumulative doses.

If acne isn’t caused by a hormonal imbalance or diet issue but rather by seborrheic dermatitis, which makes the sebaceous glands overproduce oil, wouldn’t Accutane only treat the acne but not actually cure it since the underlying seb derm would still keep the glands active and the acne would eventually come back once you stop given that it’s a chronic condition? Wouldn’t a full-dose cycle of isotretinoin to give a reset and shrink the glands followed by a microdose routine make more sense?

 

[Ateam2023]

If acne isn’t caused by a hormonal imbalance or diet issue but rather by seborrheic dermatitis, which makes the sebaceous glands overproduce oil, wouldn’t Accutane only treat the acne but not actually cure it since the underlying seb derm would still keep the glands active and the acne would eventually come back once you stop given that it’s a chronic condition? Wouldn’t a full-dose cycle of isotretinoin to give a reset and shrink the glands followed by a microdose routine make more sense?

 

[Ateam2023]

If acne isn’t caused by a hormonal imbalance or diet issue but rather by seborrheic dermatitis, which makes the sebaceous glands overproduce oil, wouldn’t Accutane only treat the acne but not actually cure it since the underlying seb derm would still keep the glands active and the acne would eventually come back once you stop given that it’s a chronic condition? Wouldn’t a full-dose cycle of isotretinoin to give a reset and shrink the glands followed by a microdose routine make more sense?

use the search function, this has been discussed before, at length,

 

[Banana Joe]

Better results since it's systemic, reaching deeper than a topical can, and thus far, appear to be lasting effects

Earlier studies that used simple, subjective measures of improvement suggested the results were equal, but newer methods that can measure the remodeling of collagen show significant, durable differences.

It's very telling that in recent years a lot of staff members of dermatologist offices have gone onto low dose isotretinoin regimens.

And also there's the simplicity of a couple of gelcaps a week, that benefits skin everywhere on the body, vs a time consuming topical application.

Durability of the improvement of collagen I and collagen III with the use of oral isotretinoin in the treatment of photoaging - PubMed

Low-dose ISO is effective in remodeling the extracellular matrix (ECM). This study found that the increase of collagen occurs through the augmentation of both collagen I and collagen III fibers. With originality, it was possible to verify the durability of these fibers for at least 12 weeks...

pubmed.ncbi.nlm.nih.gov

What is then there to say against taking Isotretinoine indefinitely at a dose of let*s say 2-3*10mg (smallest gel capsule available?!) instead of applying tretinoin cream for the rest of one's life? Or taking it in such low dose dose cycles every year for maybe 3 months?
The cumulative dose recommendations would not be exceeded with these dosages, if that even has any meaning, if done over the course of a decade or more.

EDIT: I guess I found the reply myself...

Everything you need to know is in the "Accutane permanent cure" thread, but
...
I liked the improvement so much a year after finishing the full course I started using a 5mg microdose daily for the anti-aging effect of sped up skin turnover and collagen regeneration.
...
High end private derms in the US prescribe isotretinoin for this anti-aging protocol...

 

[Ateam2023]

@Banana Joe , this is from meamoshop, all kinds of fillers etc , just quality products, i have to say , those are the top products on the website

 

[Banana Joe]

@Banana Joe , this is from meamoshop, all kinds of fillers etc , just quality products, i have to say , those are the top products on the website

Thanks, I wasn't looking for fillers though. I just stumbled across this thread due to the microdosing of Isotretinoin thing.

Fillers are like SEO's. I am aware everyone uses them in modern bodybuilding, but I have to draw the line somewhere for me.
Personally, I just want to accentuate my natural beauty with the help of modern pharmacology.

 

[june43]

use the search function, this has been discussed before, at length,

cannot find any mention with seborrheic dermatitis and accutane in the same comment

 

[JK1]

Thanks, I wasn't looking for fillers though. I just stumbled across this thread due to the microdosing of Isotretinoin thing.

Fillers are like SEO's. I am aware everyone uses them in modern bodybuilding, but I have to draw the line somewhere for me.
Personally, I just want to accentuate my natural beauty with the help of modern pharmacology.

Did you decide to start low dose isotretinoin infrequently?

 

[maxtom]

Snap-8 (Acetyl Octapeptide-3)​

• How it works: Snap-8 is a peptide similar to Argireline, but it’s slightly more effective at reducing facial tension. It works by reducing the release of neurotransmitters involved in muscle contraction, leading to smoother skin.
• Effectiveness: Some studies suggest that Snap-8 can help with fine lines and wrinkles, offering a non-invasive way to smooth the skin.

 

[Ateam2023]

Snap-8 (Acetyl Octapeptide-3)​

• How it works: Snap-8 is a peptide similar to Argireline, but it’s slightly more effective at reducing facial tension. It works by reducing the release of neurotransmitters involved in muscle contraction, leading to smoother skin.
• Effectiveness: Some studies suggest that Snap-8 can help with fine lines and wrinkles, offering a non-invasive way to smooth the skin.

I just wish snap 8 wasn't so expensive, I would like to include that in my skin care routine, but the price I get my tox products is such a better decision for me and it's more effective