How long can I run DNP?

[mrsloppyboo]

I’m on week 3. Did 5 days 250, 7 days 400mg and finishing it off with 500mg powder DNP. I’m exhausted. Lethargy and water weight are real. The heat sucks but is manageable. I want to extend my cycle and get even leaner. Does the body build a tolerance to DNP? I hear different things from different people

 

[Banana Joe]

1mg will be extremely hard to cap..

Just mix it properly in stages with starch and you made it less concentrated. It is not like you will die from accidentally capping 1.5mg, instead of 1mg.

 

[Deadpool99]

Not really, if you look at the clinical literature from when it was medically prescribed in the 30's, this issue seemed to be most common in women

The only strong negative experience I had with DNP was a breakout of allergic hives all over my skin the very first time I used it

I actually never knew that, kodus to your research. Apparently my understanding of the cataracts risks wasn't as straight forward as I thought it was.

ChatGPT said:​

In the 1930s, cataracts were reported mainly in women—about 80–90 % of the documented cases. Doctors at the time thought this was likely because women were smaller, often received similar absolute doses, and had poorer vitamin or antioxidant status, not because men were immune.

At a single 250 mg/day dose run briefly, the absolute likelihood of developing cataracts is indeed very low—especially for a healthy, well-nourished young male—but it’s not truly negligible.

Here’s the nuance:

- In the 1930s clinical data, cataracts typically appeared after several weeks to months of continuous exposure at ≥ 300–400 mg/day.

- No acute cataracts were recorded below ~250 mg/day in short-term use, and most occurred in older, vitamin-deficient women who took DNP for months.

- The mechanism (oxidative stress in lens cells) exists at any dose, so a small baseline risk remains, but it rises steeply with dose, duration, dehydration, or heat stress.

 

[Anonymous member 154437]

I was 205lbs with abs just a few weeks ago

It hurts my soul going from the biggest dude in my gym to this.

planet fitness?

 

[xrayphoton13]

Not really, if you look at the clinical literature from when it was medically prescribed in the 30's, this issue seemed to be most common in women

The only strong negative experience I had with DNP was a breakout of allergic hives all over my skin the very first time I used it

I don't get the hives but I sure get itchy in my armpits the first few days. Very odd

 

[ChemBB]

With all due respect brother I’m an influencer with a decent following and last year came very close to turning pro and have some very unique tattoos lol and would prefer to keep my identity secret. I’ll post whatever stats you want though

Hit up my DM's?

Super curious what you look like, if you're willing to private msg

 

[ChemBB]

I don't get the hives but I sure get itchy in my armpits the first few days. Very odd

It only happened the first time I ran it.

Was actually pretty bad, I itched soooo bad all over my body, sort of like Chicken Pox. I was pounding Benadryl and feeling like shit, I quit after a few days.

Afraid to try it again but when I finally did years later, reaction didn't happen, and it never has since.

 

[Banana Joe]

ChatGPT said:​

In the 1930s, cataracts were reported mainly in women—about 80–90 % of the documented cases. Doctors at the time thought this was likely because women were smaller, often received similar absolute doses, and had poorer vitamin or antioxidant status, not because men were immune.

At a single 250 mg/day dose run briefly, the absolute likelihood of developing cataracts is indeed very low—especially for a healthy, well-nourished young male—but it’s not truly negligible.

Here’s the nuance:

- In the 1930s clinical data, cataracts typically appeared after several weeks to months of continuous exposure at ≥ 300–400 mg/day.

- No acute cataracts were recorded below ~250 mg/day in short-term use, and most occurred in older, vitamin-deficient women who took DNP for months.

- The mechanism (oxidative stress in lens cells) exists at any dose, so a small baseline risk remains, but it rises steeply with dose, duration, dehydration, or heat stress.

Thanks, it would have been great if you could have linked or named the sources. Having the summary in mg/kg would be preferred, I assume even a fat woman in the 1930 was likely lighter even than the lighter men on this board, let alone having a lot less LBM on top of that.

If possible, please try to put such quotes in italic, makes it easier to read as quote.

So if oxidative stress is well managed, the risk at <=2-3mg/kg is likely very low?

 

[Deadpool99]

Thanks, it would have been great if you could have linked or named the sources. Having the summary in mg/kg would be preferred, I assume even a fat woman in the 1930 was likely lighter even than the lighter men on this board, let alone having a lot less LBM on top of that.

If possible, please try to put such quotes in italic, makes it easier to read as quote.

So if oxidative stress is well managed, the risk at <=2-3mg/kg is likely very low?

My bad, here you go.

From the original medical literature (Cutting & Tainter, JAMA, 1933; Simkins, Am J Med Sci, 1937; Rabinowitch & Fowler, CMAJ, 1934):

Typical “therapeutic” DNP doses were 100–300 mg/day, equivalent to roughly 2–4 mg/kg/day for an average 50–60 kg adult female in the 1930s.

Cataracts appeared mostly after prolonged administration (>6–12 weeks) at doses around 300–400 mg/day (≈5–7 mg/kg/day)

In early reports covering >10,000 patients, the majority of cataract cases occurred in women, usually undernourished or vitamin-deficient, taking the same absolute dose as men.

No cataracts were observed in subjects exposed for short durations (<3 weeks) below ~250 mg/day (~3–4 mg/kg/day).

References:

https://jamanetwork.com/journals/jama/fullarticle/1154261?utm_source=chatgpt.com

USE OF DINITROPHENOL IN OBESITY AND RELATED CONDITIONS

We1 have recently suggested that alpha-dinitrophenol (1-2-4) might have therapeutic value in conditions in which an increased metabolic rate would be beneficial. Study of its pharmacologic properties shows that it has the power to increase metabolism to very high levels without causing important...

jamanetwork.com

Cataracts produced by dinitrophenol; an experimental study - PubMed

Cataracts produced by dinitrophenol; an experimental study

pubmed.ncbi.nlm.nih.gov

Diet pills and the cataract outbreak of 1935: reflections on the evolution of consumer protection legislation - PubMed

An outbreak of cataracts in 1935 caused by dinitrophenol (DNP), the active ingredient of popular diet pills, highlighted the inability of the U.S. Food and Drug Administration (FDA) to prevent harmful drugs from entering the marketplace. Just two years earlier, the FDA used horrific images of...

pubmed.ncbi.nlm.nih.gov

2,4 Dinitrophenol as Medicine - PMC

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest ...

pmc.ncbi.nlm.nih.gov

 

[Deadpool99]

So if oxidative stress is well managed, the risk at <=2-3mg/kg is likely very low?

So I believe so, if oxidative stress is well managed, and the dose is ≤ 2–3 mg/kg/day with limited duration, the cataract risk is very low but not nonexistent.

Holy shit, these women were taking 300–400 mg, weighing about 50 kg, equivalent to roughly 6–8 mg/kg/day and even worse most had been on the drug continuously for 2–6 months without vitamin or antioxidant support. Fuck me

 

[mrsloppyboo]

Gentlemen I gave into cravings as my family made cornbread last night so took an extra pill. So fucking hot. That totals 900ng DNP yesterday and just downed another 900. I’ll go back to 600 for the weekdays when I have work. Worst fucking night of my life. Woke every two hours to pee or poop. So fucking hot. Just heat. So awful. It was maybe 150g carbs

 

[Banana Joe]

My bad, here you go.
....

Thanks!

So I believe so, if oxidative stress is well managed, and the dose is ≤ 2–3 mg/kg/day with limited duration, the cataract risk is very low but not nonexistent.

Holy shit, these women were taking 300–400 mg, weighing about 50 kg, equivalent to roughly 6–8 mg/kg/day and even worse most had been on the drug continuously for 2–6 months without vitamin or antioxidant support. Fuck me

I wonder if there is even a point in running 2mg/kg or less.
At that dose you would still have to diet rather long, meaning likely getting catabolic at some point, whereas the DNP-blitzing could mean you can push and pull your calories harder and (perhaps) gain more lean mass if everything is timed well. Not sure I would go as low as @mrsoppyboo, but I think the general strategy is intriguing and not really replicable with other drugs like Reta.
Still not convinced about the safety though, for obvious reasons.

I checked and you can test for oxidative stress with simple MDA pee sticks, or 8-isoprostane or 8-oxodG markers, when doing bloodwork.
Maybe this could be applied as a safety measure? If oxidative stress is what causes the cataract, wouldn't that be pretty much dose independent of DNP, if the OS is properly managed?

@mrsloppyboo, could you maybe check that for us and post the results, and again later with no DNP, to get a baseline reading? It would be awesome to get a reading at 900mg. Do you specifically up the cardio, given that your overall metabolic rate is raised?

What other issues do arise with higher doses of DNP, assuming you don't run too hot?

Is anyone running this with Clen? Seems the obvious thing to do, and to keep the DNP dose in a lower range.

Worst fucking night of my life. ... So fucking hot. Just heat. So awful. It was maybe 150g carbs

Wait, I can't eat 150g of carbs in one meal? How much can I eat if running 2-4mg/kg?

 

[Deadpool99]

Wait, I can't eat 150g of carbs in one meal? How much can I eat if running 2-4mg/kg?

I love a big dinner at night and lights meals in the morning.My dinner is usually consistently 140g carbs

 

[Banana Joe]

I love a big dinner at night and lights meals in the morning.My dinner is usually consistently 140g carbs

How is that a big meal? Before I fell off the horse again, my PWO-meal was 200g, all other meals were around 150g to maintain my weight. If I felt that I need a bit more carbs, I always ate 250g of pasta as an alternative meal.
What do you guys eat throughout the entire day?

 

[mrsloppyboo]

Thanks!


I wonder if there is even a point in running 2mg/kg or less.
At that dose you would still have to diet rather long, meaning likely getting catabolic at some point, whereas the DNP-blitzing could mean you can push and pull your calories harder and (perhaps) gain more lean mass if everything is timed well. Not sure I would go as low as @mrsoppyboo, but I think the general strategy is intriguing and not really replicable with other drugs like Reta.
Still not convinced about the safety though, for obvious reasons.

I checked and you can test for oxidative stress with simple MDA pee sticks, or 8-isoprostane or 8-oxodG markers, when doing bloodwork.
Maybe this could be applied as a safety measure? If oxidative stress is what causes the cataract, wouldn't that be pretty much dose independent of DNP, if the OS is properly managed?

@mrsloppyboo, could you maybe check that for us and post the results, and again later with no DNP, to get a baseline reading? It would be awesome to get a reading at 900mg. Do you specifically up the cardio, given that your overall metabolic rate is raised?

What other issues do arise with higher doses of DNP, assuming you don't run too hot?

Is anyone running this with Clen? Seems the obvious thing to do, and to keep the DNP dose in a lower range.


Wait, I can't eat 150g of carbs in one meal? How much can I eat if running 2-4mg/kg?

Cardio? Lmao cardio at 900mg DNP is asking for death

 

[Deadpool99]

How is that a big meal? Before I fell off the horse again, my PWO-meal was 200g, all other meals were around 150g to maintain my weight. If I felt that I need a bit more carbs, I always ate 250g of pasta as an alternative meal.
What do you guys eat throughout the entire day?

I eat 600g chicken and an entire box of low carb high fiber pasta. (16oz i think). The volume is insane. This is me on a cut. Shit changes on a bulk/maintenance tho

For reference this is a pic of my pasta. Don’t be fooled by the insanely large platter

 

[Banana Joe]

I eat 600g chicken and an entire box of low carb high fiber pasta. (16oz i think). The volume is insane. This is me on a cut. Shit changes on a bulk/maintenance tho

For reference this is a pic of my pasta. Don’t be fooled by the insanely large platter

I wanna eat less, not more - therefore I'd never eat low carb pasta!
If I could, I would live on two solid meals and the rest is shakes of highly soluble carbs and protein. I hate being full.
That would be my dream, sigh.

Also, I don't think that 600g of any meat, even if chicken is a good choice, for a single meal. I doubt that will contribute to optimal digestion. So will the high fiber pasta, I guess.
Usually I eat 170-200g of meat and a whey isolate shake to increase protein per meal.

Have you been fat before?

 

[Deadpool99]

I wanna eat less, not more - therefore I'd never eat low carb pasta!
If I could, I would live on two solid meals and the rest is shakes of highly soluble carbs and protein. I hate being full.
That would be my dream, sigh.

I eat low carb pasta for the volume, though my total carbs are high.

This was my maintenance calories dinner, tho I think later I did up my carbs even higher. But I finished my subscription so I couldn’t get my logged meals.

 

[Banana Joe]

Cardio? Lmao cardio at 900mg DNP is asking for death

I guess I am too old school, but I think I would run less DNP, maybe some clen (which I have never taken) and do LISS cardio, which I actually learned to enjoy.

 

[mrsloppyboo]

I guess I am too old school, but I think I would run less DNP, maybe some clen (which I have never taken) and do LISS cardio, which I actually learned to enjoy.

This is just for the last week and a half before I take a deload week then start my bulk. Dropping as much fat as possible. Idk how on earth you guys eat carbs on DNP. I just took a 45 minute cold bath bc I decided to have rice cakes and a bunch of fruit like an idiot

 

[xrayphoton13]

This is just for the last week and a half before I take a deload week then start my bulk. Dropping as much fat as possible. Idk how on earth you guys eat carbs on DNP. I just took a 45 minute cold bath bc I decided to have rice cakes and a bunch of fruit like an idiot

But you're also taking 900mg which just seems a bit high. I read a case report where an 18 year old died after taking 1g DNP for three days straight. You're a brave man. I can somewhat handle 400mg but I bumped to 600mg for one day and never again. Everything I did had me sweating