I try make my health decisions by looking at the studies that lead the next round of treatment guideline updates (that take 10 years, 200 studies, and 1500 doctors to all agree on whether there’s sufficient evidence to change anything). I can tell you anything above 1mg has been understood to be a red flag for a long time, with vascular surgeons saying, basically, when operating, they’ve noticed patients with CRP >1 for extended periods have blood vessels that are in bad shape. I just read “age related hearing loss” is likely due to this type of inflammation destroying micro vessels that feed nerves in the ear.
But as you probably know, HS-CRP can jump up and down, and one reading isn’t good enough, also, it won’t be accurate on a heavy workout day or if you’ve taken an NSAID.
Cardio brings it down a bit. Fat loss helps.
GLP-1’s do a good job at reducing systemic inflammation (separate from weight loss).
Statins are the systemic anti-inflammation gorilla (50-60% reduction in a week), and the American College of Cardiologists (the main org representing cardiologists) now suggests using one if necessary, even if lipids are normal, to get HS-CRP below 1.