Ghoul
Member
I wonder if this is due to suppressed BDNF. You see the same degenerative pathology in depression or anxiety.
I've noticed that SSRI/NaSSA combo offsets most of the psychological effects (at a moderate dose).
Seems that long term androgen use dose the same thing (mood disorders, anxiety etc).
Could be.

Frontiers | Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Sleep deprivation(SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxid...
Now I’m not suggesting Modafinil counters AAS induced cognitive impairment, restores neuroplasticity and the ability to problem solve…. But it does.

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