Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

I wonder if this is due to suppressed BDNF. You see the same degenerative pathology in depression or anxiety.

I've noticed that SSRI/NaSSA combo offsets most of the psychological effects (at a moderate dose).

Seems that long term androgen use dose the same thing (mood disorders, anxiety etc).

Could be.

IMG_4170.webp


Now I’m not suggesting Modafinil counters AAS induced cognitive impairment, restores neuroplasticity and the ability to problem solve…. But it does.

IMG_4172.webp


 
Last edited:
Could be.

View attachment 369659


Now I’m not suggesting Modafinil counters AAS induced cognitive impairment, restores neuroplasticity and the ability to problem solve…. But it does.

View attachment 369656


Changing my username to PermablastingModafinil.

Jokes aside it's good to know I intuitively stumbled on a stack that helped my brain function. Dopamine is neurotoxic. So I do wonder if it's related to that. Also AAS users tend to abuse other dopaminergic drugs. So how much is tren vs the personality type....

I couldn't for the life of me understand why SSRI medications aren't classified as performance enhancing because they enable you to endure a lot more stress than you'd be able to under normal conditions enhancing mental resilience.
 
Could be.

View attachment 369659


Now I’m not suggesting Modafinil counters AAS induced cognitive impairment, restores neuroplasticity and the ability to problem solve…. But it does.

View attachment 369656


Question. Is it safe to low dose moda daily ? Say 50mg a day
 
Changing my username to PermablastingModafinil.

Jokes aside it's good to know I intuitively stumbled on a stack that helped my brain function. Dopamine is neurotoxic. So I do wonder if it's related to that. Also AAS users tend to abuse other dopaminergic drugs. So how much is tren vs the personality type....

I couldn't for the life of me understand why SSRI medications aren't classified as performance enhancing because they enable you to endure a lot more stress than you'd be able to under normal conditions enhancing mental resilience.
They tend to not help with stress during athletic performance, it’s more anticipatory stress
 
Question. Is it safe to low dose moda daily ? Say 50mg a day

Not only is it safe to use Modafinil daily (it’s FDA approved for daily use at 50, 100, or 200mg / day), there are patients who’ve used it for over 20 years with no negative effects. No one has ever been harmed (other than by sleep loss) even at doses up to 10,000 mg (suicide attempt).

If anything, all signs (and literally 100+ studies) show it enhances function and protects the brain, even preserving brain function in cases of stroke and traumatic injury to brain tissue. More relevantly, it protects the brain against cumulative oxidative damage (aka aging) from stress, sleep loss, and other sources like AAS use.

Provigil = Modafinil
Nuvigil = Armodafinil


View: https://youtu.be/PAKS0aVhGto


View: https://youtube.com/shorts/c446afqoC78
 
Last edited:
Not only is it safe to use Modafinil daily (it’s FDA approved for daily use at 50, 100, or 200mg / day), there are patients who’ve used it for over 20 years with no negative effects. No one has ever been harmed (other than by sleep loss) even at doses up to 10,000 mg (suicide attempt).

If anything, all signs (and literally 100+ studies) show it enhances function and protects the brain, even preserving brain function in cases of stroke and traumatic injury to brain tissue. More relevantly, it protects the brain against cumulative oxidative damage (aka aging) from stress, sleep loss, and other sources like AAS use.

Provigil = Modafinil
Nuvigil = Armodafinil


View: https://youtu.be/PAKS0aVhGto


View: https://youtube.com/shorts/c446afqoC78

Would it not be risky since so many on TRT or higher dosed AAS have problems sleeping?
 
Just wanna comment on a recent problem- ordered 3kits of pt141 back in September. Finished off one kit that I know was pt141 and recently started using the second kit and am on my second vial and can 100% confirm that this kit is mt2-not pt141. I’ve ran pt141 for almost 2 years now and had mt2 in the past on and off and know which is which. Usually I wouldn’t GAF but it sucks since cause mt2 made my skin in the past damn near Indian and I was never gonna use it again cause of that fact and what do you know? That skin tone is coming on again and took months of stopping to slowly get my old tone back. Shit happens. Glad I caught it early tho
 
Not only is it safe to use Modafinil daily (it’s FDA approved for daily use at 50, 100, or 200mg / day), there are patients who’ve used it for over 20 years with no negative effects. No one has ever been harmed (other than by sleep loss) even at doses up to 10,000 mg (suicide attempt).

If anything, all signs (and literally 100+ studies) show it enhances function and protects the brain, even preserving brain function in cases of stroke and traumatic injury to brain tissue. More relevantly, it protects the brain against cumulative oxidative damage (aka aging) from stress, sleep loss, and other sources like AAS use.

Provigil = Modafinil
Nuvigil = Armodafinil


View: https://youtu.be/PAKS0aVhGto


View: https://youtube.com/shorts/c446afqoC78

Modafinil is a classified drug where I live, I have enough LE risk, how about things like Alpha-GPC, and L carn for neuro protection?
 
Does anyone here use their oils; I just want test, but about a year ago I ordered a kit of test and mast and they had unbelievable amounts of floaters in almost every vial. Anyone who has bought recently have any idea?
 
Just wanna comment on a recent problem- ordered 3kits of pt141 back in September. Finished off one kit that I know was pt141 and recently started using the second kit and am on my second vial and can 100% confirm that this kit is mt2-not pt141. I’ve ran pt141 for almost 2 years now and had mt2 in the past on and off and know which is which. Usually I wouldn’t GAF but it sucks since cause mt2 made my skin in the past damn near Indian and I was never gonna use it again cause of that fact and what do you know? That skin tone is coming on again and took months of stopping to slowly get my old tone back. Shit happens. Glad I caught it early tho
I strongly doubt this for various reasons:

1) all PT141 batchs in september were tested because they belong to 2024 inventory and every single batch of it was tested as you all know: Janoshik Analytical

2) same for MT2, all batchs in 2024 were tested as well; often if not always with yellow lids: Janoshik Analytical

3) PT141 10mg have the SKU next to bar code: 017PT10MG for all kits sold in september

4) no buyer bought 3 kits PT141 at once by then in september, you either bought more or less, the only buyer who bought 3 kits exacly, and that was in was in august.

5) What you're experiencing is a side effect from long use / high dose of p141, PT-141 is a synthetic peptide that activates melanocortin receptors in the body, specifically the MC3R and MC4R. The name "melanocortin" comes from its historical link to melanocyte-stimulating hormone (MSH), which does stimulate melanocytes in the skin to produce melanin (pigment). It can cause a mottled, uneven, and generalized hyperpigmentation often described as a "dirty" or "muddy" look because it stimulates melanin production systemically and inconsistently across the skin, rather than in a smooth, sun-induced manner. This effect typically darkens existing freckles and moles more prominently and can create a patchy, grayish-brown tone that lacks the natural gradient of a UV-based tan, leading to the perception of an unnatural or "dirty" appearance.
 
I strongly doubt this for various reasons:

1) all PT141 batchs in september were tested because they belong to 2024 inventory and every single batch of it was tested as you all know: Janoshik Analytical

2) same for MT2, all batchs in 2024 were tested as well; often if not always with yellow lids: Janoshik Analytical

3) PT141 10mg have the SKU next to bar code: 017PT10MG for all kits sold in september

4) no buyer bought 3 kits PT141 at once by then in september, you either bought more or less, the only buyer who bought 3 kits exacly, and that was in was in august.

5) What you're experiencing is a side effect from long use / high dose of p141, PT-141 is a synthetic peptide that activates melanocortin receptors in the body, specifically the MC3R and MC4R. The name "melanocortin" comes from its historical link to melanocyte-stimulating hormone (MSH), which does stimulate melanocytes in the skin to produce melanin (pigment). It can cause a mottled, uneven, and generalized hyperpigmentation often described as a "dirty" or "muddy" look because it stimulates melanin production systemically and inconsistently across the skin, rather than in a smooth, sun-induced manner. This effect typically darkens existing freckles and moles more prominently and can create a patchy, grayish-brown tone that lacks the natural gradient of a UV-based tan, leading to the perception of an unnatural or "dirty" appearance.

Appreciate the detailed response — I want to clarify that I’m not claiming certainty. I apologize for claiming 100% prior. only explaining why MT-2 remains a reasonable possibility based on experience and symptom profile.

Again I apologize for my claim that I ordered the products in September. The order was placed on August 18th. I thought it placed was at the beginning of September.

Like I said- I’ve used PT-141 consistently for ~2 years and am very familiar with its CNS and peripheral effects at varying doses. What raised concern this time was the combination and timing of effects:


Rapid and noticeable skin tone change resembling prior MT-2 exposure

• Changes occurring without UV exposure

• The specific “muddy / generalized” pigmentation pattern I’ve personally only experienced with MT-2, not PT-141

• CNS effects that felt qualitatively different than my usual PT-141 response

•another additional factor for me was appetite suppression. In my past MT-2 use, appetite suppression was consistent and noticeable. Over ~2 years of PT-141 use, I’ve never experienced that effect — only transient flushing and short-lived nausea (1–2 hours max).

This recent experience included appetite suppression similar to what I’ve only associated with MT-2- and it was a pretty pronounced and suddenly started right as I opened up the new kit and started using the first vial. This is why it stood out to me as a possible explanation.

I understand PT-141 does activate melanocortin receptors and can theoretically cause pigmentation at higher or prolonged doses, but in my use of 2 years now, those effects have been absent and the pigmentation change was noticeable and occurred without sun exposure which stood out given the season, limited daylight, and lack of UV exposure where I’m currently located.



I’m not disputing testing protocols and making insane accusations — pt141 isn’t a huge dent in my wallet and I’ve had success for almost 3 years now ordering from you. Of these 3 years this 1 kit has been my only complaint/ problem I’ve had. Again I’m only noting that based on personal comparison to past MT-2 exposure, the presentation felt more consistent with MT-2 than with PT-141 alone.

Either way, I’ve discontinued use and like I said I’m glad I caught it only 1 and a half vials in.
 
Appreciate the detailed response — I want to clarify that I’m not claiming certainty. I apologize for claiming 100% prior. only explaining why MT-2 remains a reasonable possibility based on experience and symptom profile.

Again I apologize for my claim that I ordered the products in September. The order was placed on August 18th. I thought it placed was at the beginning of September.

Like I said- I’ve used PT-141 consistently for ~2 years and am very familiar with its CNS and peripheral effects at varying doses. What raised concern this time was the combination and timing of effects:


Rapid and noticeable skin tone change resembling prior MT-2 exposure

• Changes occurring without UV exposure

• The specific “muddy / generalized” pigmentation pattern I’ve personally only experienced with MT-2, not PT-141

• CNS effects that felt qualitatively different than my usual PT-141 response

•another additional factor for me was appetite suppression. In my past MT-2 use, appetite suppression was consistent and noticeable. Over ~2 years of PT-141 use, I’ve never experienced that effect — only transient flushing and short-lived nausea (1–2 hours max).

This recent experience included appetite suppression similar to what I’ve only associated with MT-2- and it was a pretty pronounced and suddenly started right as I opened up the new kit and started using the first vial. This is why it stood out to me as a possible explanation.

I understand PT-141 does activate melanocortin receptors and can theoretically cause pigmentation at higher or prolonged doses, but in my use of 2 years now, those effects have been absent and the pigmentation change was noticeable and occurred without sun exposure which stood out given the season, limited daylight, and lack of UV exposure where I’m currently located.



I’m not disputing testing protocols and making insane accusations — pt141 isn’t a huge dent in my wallet and I’ve had success for almost 3 years now ordering from you. Of these 3 years this 1 kit has been my only complaint/ problem I’ve had. Again I’m only noting that based on personal comparison to past MT-2 exposure, the presentation felt more consistent with MT-2 than with PT-141 alone.

Either way, I’ve discontinued use and like I said I’m glad I caught it only 1 and a half vials in.
I checked the record of your order, it's confirmed PT141 (SKU=017PT10MG), with no room for error, since MT2 wasn't stocked in that warehouse, so it's impossible to have it in that pack.

You haven't commented on the color of lids, which one you have, maybe you can post a picture of it.
 
Back
Top