Fasting in general affects mitochndria a lot. The absence of insulin/carbs even more so. The main reason why the carnivor diet works so well for many mental illnesses is the effects on the mitochndria.
So my line of thought was: at least take it in the morning on a fasted sate and in the absence of insuline/carbs and maybe even pair it with some cardio.
(People always forget that our ancestors basically ate no carbs. During the ice age our diet consisted of meat. Protein and fat. Almost no berrys,nuts or fruits. And if you ever tasted a wild pear, you know that wild fruits a far from loaded with sugar.
"low energy/nutrient signaling (higher AMP/ADP:ATP, lower mTOR) tends to activate AMPK and therefore PGC-1α, a canonical pathway that promotes mitochondrial biogenesis and oxidative capacity. This is one route by which ketogenic or low-carb states can increase mitochondrial content and oxidative enzymes in muscle and liver in many studies.
The impact of diet upon mitochondrial physiology (Review):
The impact of diet upon mitochondrial physiology (Review) - PMC"
"β-hydroxybutyrate (BHB) is not just fuel — it has signaling roles (HDAC inhibition, receptor effects) that can up-regulate antioxidant defenses, mitochondrial gene expression and even mitochondrial dynamics/mitochondrial-derived vesicle formation in experimental systems. That can protect mitochondria from excitotoxic or oxidative stress in some models.
The Impact of Ketone Body Metabolism on Mitochondrial Function and Cardiovascular Diseases:
The Impact of Ketone Body Metabolism on Mitochondrial Function and Cardiovascular Diseases - PMC"
