Defiant Pharma (US Domestic)

[The Answ3r]

I find taking the pre-workout, TNE, Sdrol, Adrol, work best 90 to 120 minutes before heavy lifting. What timing works the best for the rest of you?

When you say heavy lifting with something like TNE or Sdrol as a pre, what are we actually talking about? Real heavy compound work, 85-90% 1RM, low reps, pushing strength? Or just “feels heavy because the pre is kicking”?

Sometimes I see stacks like that and wonder if guys are preparing for a powerlifting meet… or just trying to bench press their own ego.

No shade, just genuinely curious what numbers and intensity we’re calling heavy.

 

[RockyP]

When you say heavy lifting with something like TNE or Sdrol as a pre, what are we actually talking about? Real heavy compound work, 85-90% 1RM, low reps, pushing strength? Or just “feels heavy because the pre is kicking”?

Sometimes I see stacks like that and wonder if guys are preparing for a powerlifting meet… or just trying to bench press their own ego.

No shade, just genuinely curious what numbers and intensity we’re calling heavy.

I think it’s different for each application. Powerlifters have some gnarly pre workout blends that I’ve seen (like 100 mg each of anadrol and anavar with a side of halo). Personally I just pick and choose between anadrol, anavar, and tne on back / leg / lagging bodypart days. The goal for me is optimal endurance, intensity, pumps, and anticatabolism. And it’s fun.

 

[The Answ3r]

I think it’s different for each application. Powerlifters have some gnarly pre workout blends that I’ve seen (like 100 mg each of anadrol and anavar with a side of halo). Personally I just pick and choose between anadrol, anavar, and tne on back / leg / lagging bodypart days. The goal for me is optimal endurance, intensity, pumps, and anticatabolism. And it’s fun.

That’s wild but I respect it. Everybody’s got their own mad scientist formula I guess.

In 20 years of lifting, and about 10 of that with gear, the craziest “pre” I’ve used was the old school Jack3d, some var, winny, and lately 100 mg of Armodafinil just to stay locked in and actually finish what I started. That’s been enough for heavy sets, pump days, whatever the goal is.

Maybe that’s why I’m not Mr. Olympia yet… no TNE, no Sdrol, no 100 mg Anadrol cocktails before squats. Clearly I’ve been doing it wrong this whole time.

I might experiment one day just to see what the hype is about. But lately I’ve been backing off the ego lifting anyway. Old injuries are starting to send reminder emails, and they don’t care how good the pre-workout stack is.

Appreciate you sharing though. Always interesting to see how different people approach it.

 

[Defiant Pharma]

T400 is all sold out fellas!

Have to wait on more TE raw to get here before I can make any more. It's in transit but I don't have an ETA right now.

regards,

D.

 

[RockyP]

T400 is all sold out fellas!

Have to wait on more TE raw to get here before I can make any more. It's in transit but I don't have an ETA right now.

regards,

D.

Wow that was quick. Not surprised. Great stuff.

 

[Defiant Pharma]

Wow that was quick. Not surprised. Great stuff.

Yeah, it flew off the shelves literally.

I will make some bigger batches once we secure more raws.

 

[713HTX]

Yeah, it flew off the shelves literally.

I will make some bigger batches once we secure more raws.

Please do. I plan on ordering at least 5-6!

 

[PMercy1]

I think it’s different for each application. Powerlifters have some gnarly pre workout blends that I’ve seen (like 100 mg each of anadrol and anavar with a side of halo). Personally I just pick and choose between anadrol, anavar, and tne on back / leg / lagging bodypart days. The goal for me is optimal endurance, intensity, pumps, and anticatabolism. And it’s fun.

And it’s fun.. facts bro

 

[AlexDavis43]

That’s wild but I respect it. Everybody’s got their own mad scientist formula I guess.

In 20 years of lifting, and about 10 of that with gear, the craziest “pre” I’ve used was the old school Jack3d, some var, winny, and lately 100 mg of Armodafinil just to stay locked in and actually finish what I started. That’s been enough for heavy sets, pump days, whatever the goal is.

Maybe that’s why I’m not Mr. Olympia yet… no TNE, no Sdrol, no 100 mg Anadrol cocktails before squats. Clearly I’ve been doing it wrong this whole time.

I might experiment one day just to see what the hype is about. But lately I’ve been backing off the ego lifting anyway. Old injuries are starting to send reminder emails, and they don’t care how good the pre-workout stack is.

Appreciate you sharing though. Always interesting to see how different people approach it.

squats

that's the main reason

who has been consistently going heavy on leg day for years?

answer: big mother fuckers

 

[The Answ3r]

that's the main reason

who has been consistently going heavy on leg day for years?

answer: big mother fuckers

But it’s 2026 and people are still acting like barbell back squats are the only path to Valhalla. Nah. That era had its fun.

I squatted my share back in the day. It was cool, loud, ego-boosting, everyone clapping when you unrack 5 plates. But once I dropped the straight bar and focused on hack squats, pendulum, heavy leg press, and some belt squat work, my legs actually started growing instead of my chiropractor’s income.

You can load the hell out of those movements, control the path, and keep tension where it belongs instead of surviving the lift like it’s a car crash in slow motion.

But at the end of the day, we’re all wired different. Some guys build tree trunks off back squats. Others build them off machines. We’re all just trying to grow and not limp into 40.

Lift smart, lift heavy enough, and pick your poison.

 

[ThatGuy500mg]

How are yall feeling about stack EQ and NPP? That seems like it would be a synergistic combination to me. But like it would also turn your blood to sludge and but you blood pressure at 235/159. Anyone experiment with this? I’m trying to plan out a late summer bulk to build up for a show later this year. Maybe just sticking with test/EQ and possibly kickstart it with anadrol? I’m trying to not just buy a bunch of stuff blindly that I may or may not use but still be prepared for later down the road lol

 

[The Answ3r]

How are yall feeling about stack EQ and NPP? That seems like it would be a synergistic combination to me. But like it would also turn your blood to sludge and but you blood pressure at 235/159. Anyone experiment with this? I’m trying to plan out a late summer bulk to build up for a show later this year. Maybe just sticking with test/EQ and possibly kickstart it with anadrol? I’m trying to not just buy a bunch of stuff blindly that I may or may not use but still be prepared for later down the road lol

First question, is this your first time touching EQ or NPP? If yes, don’t stack them right away. That’s how you end up not knowing which compound is doing what.

If I were you, I’d start simple: Test + EQ first. Something like 500/400. Run that, pull bloods, and see what actually happens.

Two big things to watch with EQ:
1. E2 suppression (for some guys it tanks it).
2. HCT creeping up.

Those are the two common headaches. If your e2 crashes or your hct starts climbing, you’ll know EQ is the variable, not some mystery synergy.

Stacking EQ + NPP right away isn’t “synergy,” it’s more like introducing two variables that both affect RBC, blood pressure, recovery, and hormones in different ways. NPP brings prolactin and potential mental sides. EQ brings RBC and possible e2 suppression. Combine both and now you’re playing hormone roulette.

That said, solid combinations long term:
1. Test/EQ/Mast.
2. Test/NPP/Mast.

Both work very well, but once you already know how you respond individually.

As for show prep bulk, the smartest move isn’t buying everything just to have it. It’s building a solid base, watching bloodwork, then adjusting intentionally.

Anadrol as a kickstart can work, sure. But I’d still see how you respond to the core stack first before piling more stress on top.

Keep it simple. Let bloods guide you. Add complexity only when you actually need it.

 

[ThatGuy500mg]

First question, is this your first time touching EQ or NPP? If yes, don’t stack them right away. That’s how you end up not knowing which compound is doing what.

If I were you, I’d start simple: Test + EQ first. Something like 500/400. Run that, pull bloods, and see what actually happens.

Two big things to watch with EQ:
1. E2 suppression (for some guys it tanks it).
2. HCT creeping up.

Those are the two common headaches. If your e2 crashes or your hct starts climbing, you’ll know EQ is the variable, not some mystery synergy.

Stacking EQ + NPP right away isn’t “synergy,” it’s more like introducing two variables that both affect RBC, blood pressure, recovery, and hormones in different ways. NPP brings prolactin and potential mental sides. EQ brings RBC and possible e2 suppression. Combine both and now you’re playing hormone roulette.

That said, solid combinations long term:
1. Test/EQ/Mast.
2. Test/NPP/Mast.

Both work very well, but once you already know how you respond individually.

As for show prep bulk, the smartest move isn’t buying everything just to have it. It’s building a solid base, watching bloodwork, then adjusting intentionally.

Anadrol as a kickstart can work, sure. But I’d still see how you respond to the core stack first before piling more stress on top.

Keep it simple. Let bloods guide you. Add complexity only when you actually need it.

I have ran EQ once in the past when I was younger and pretty ignorant with any hormones really. Felt great for a while one it but I got pretty sluggish/anxious around week ten-12 ish? Hard to remember the exact week, it’s been almost a decade. But then I decided to drop it. NPP I ran for about three weeks and started jumping size pretty fast but this was when Covid hit and gyms shut down so I didn’t get a good feel. I actually haven’t ran any anabolics outside of that since. That will change in two weeks though. I am leaning more towards EQ, especially I’m just running that and test alone because I do want those lean dry gains. My biggest concerns with EQ is HCT and crashing my E2. I was told to have some dbol on hand in case of estrogen crashing as a quick fix. But this seems to be a very well tolerated compound by many opposed to NPP having much more negative feedback. I’ve got a few tren cycles under my belt and I actually barely had any negative sides except for the occasional night sweats and an increase in blood pressure. Mind you, these are all from 6-7+ years ago, so I may react differently as I’ve aged, if that’s a thing. But when it comes to bulking compounds, this might as well be my first time.

 

[BALLISTIC]

I have ran EQ once in the past when I was younger and pretty ignorant with any hormones really. Felt great for a while one it but I got pretty sluggish/anxious around week ten-12 ish? Hard to remember the exact week, it’s been almost a decade. But then I decided to drop it. NPP I ran for about three weeks and started jumping size pretty fast but this was when Covid hit and gyms shut down so I didn’t get a good feel. I actually haven’t ran any anabolics outside of that since. That will change in two weeks though. I am leaning more towards EQ, especially I’m just running that and test alone because I do want those lean dry gains. My biggest concerns with EQ is HCT and crashing my E2. I was told to have some dbol on hand in case of estrogen crashing as a quick fix. But this seems to be a very well tolerated compound by many opposed to NPP having much more negative feedback. I’ve got a few tren cycles under my belt and I actually barely had any negative sides except for the occasional night sweats and an increase in blood pressure. Mind you, these are all from 6-7+ years ago, so I may react differently as I’ve aged, if that’s a thing. But when it comes to bulking compounds, this might as well be my first time.

Typically I’m not big on strict ratios, but with EQ they absolutely matter.

I don’t aromatize heavily to begin with, and EQ absolutely crushes my estrogen levels. That said, it’s still one of my all time favorite compounds. We all respond differently, what works beautifully for one guy can be a disaster for another. Nandrolone is another favorite of mine; personally, I’ve only experienced positives with it.

The cycle you’re referencing is completely doable. Just understand that if you crash your E2 on EQ, nandrolone isn’t going to fix that. It might help with some joint comfort, but in my experience it doesn’t. Nandrolone does not meaningfully convert into estrogen in a way that will fix low E2 symptoms. Estrone instead.

Dbol can act as a temporary fix for a significant E2 crash. The methylestrogen component should be viewed as a bandaid, not a true solution. It can help you function, but it doesn’t correct the underlying issue.

Because you don’t yet know how you’ll respond to EQ, I’d start conservatively with something like a 3:1 or even 4:1 Test to EQ ratio. Definitely keep Dbol on hand. As mentioned, it can provide methylestrogen exposure to help manage a crashed E2 situation if it arises, but understand that effect is short lived unless it’s taken consistently. Doing this is not really a smart way to approach the fix.

Also remember if EQ does crash your E2, it’s not something that clears quickly. You’re generally looking at a minimum of several weeks, often a month or more, before levels normalize after adjustments. Plan accordingly.

 

[AllGoodThings]

Very true I do have one saved on Amazon. You just let it run 24/7?

Ya I just set it and forget it. If you're using things that are not going to be consumed in a couple weeks then I might consider only leaving it in over night but if you're doing 0.5cc TNE that should be gone in 3-4 weeks.

It takes a few hours to warm up. But if you wanted use it sparingly you could just turn it on and leave it in there overnight then take it out when you're done. It regulates itself but mines been on for weeks at 113f. My thermostat is set at 60* at all times.

There is a UV light that comes on now and then to sterilize. I'd keep the vial in a box or use amber vials if you plan to have it in there for extended periods of time. Probably won't degrade that much but still.

I would recommend testing the wipe warmer you get with a laser thermometer or similar calibrated thermometer to ensure the temps are as advertised. I went through 3 wipe warmers before I found one that consistently holds the advertised temps, the others were hotter to the tune of 20+° over advertised levels. Heat is a known enemy of most anything we want to keep from going bad, and AAS is no exception.

I keep my warmer right at 100° Fahrenheit as it seems to be a good balance for self life and keeping even more difficult compounds in solution.



My personal rule is 1 month max in the wipe warmer set to 100°. If it's going to be used slower than that, I'll just uncrash before use using a mug warmer. Same warning goes for mug warmers as did super warmers; I had to buy and return several before settling on the one I have now, which is actually exceptionally accurate and well made, albeit costing about triple of what a lot of them do, unfortunately.

 

[Inkniron87]

T400 is all sold out fellas!

Have to wait on more TE raw to get here before I can make any more. It's in transit but I don't have an ETA right now.

regards,

D.

Damn! I was just about to grab that and tne. Didn’t expect it to go that fast. Props to you D, I shouldn’t of hesitated a day