SteroidPlotter cites that study in reaching their PK numbers.
I guess the steroid plotter guys can't read. From the paper:
The median post hoc half-life was calculated to be 4.05 days for tT.
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SteroidPlotter cites that study in reaching their PK numbers.
The median post hoc half-life was calculated to be 4.05 days for tT.
It seems Kurt heard us discussing the TE vs TC structure and how TC has a cyclic ring that decreases peak serum levels (i.e., low Cmax) and increases Tmax. Thus, Kurt says TC is not effective outside of TRT. Listen to what he says for a few minutes:Theoretically, yes. In practice, not much...
Forgive me for not pulling this from original reference. Don't have that pdf handy at the moment. I am familiar with the figure though.
It seems Kurt heard us discussing the TE vs TC structure and how TC has a cyclic ring that decreases peak serum levels (i.e., low Cmax) and increases Tmax. Thus, Kurt says TC is not effective outside of TRT. Listen to what he says for a few minutes:
View: https://www.youtube.com/live/ssG11LLZptY?t=3629&si=sbdaG-nmv2QqtFJl
Appreciate the explanation.Thanks for sharing. I listened to it and respectfully it is silly. No offense to you. Nonsensical comments. He uses words such as chemistry and calculus like some of us gearheads don't grasp these concepts. In the limit of continuous infusion there can't be any difference in serum levels for TC vs TE corrected for %T in the ester. In practice, you just dose every day if you want stable blood levels. You can move Cavg by increasing dose. No magical differences between TE vs TC.
The Minto study is well covered on the forums but often misunderstood. AUC is similar for NPP vs ND (IIRC that study did have a difference in AUC for some of the sites/prodrug cases). You can see on that famous plot that NPP peaks higher then falls off faster for a single bolus Again, if you dosed NPP vs ND every day, no real difference on serum Nandrolone levels vs time. So not sure how Kurt is messing up these basic pharmacokinetic principles.