Interesting results on daily vs E3.5 day testosterone injections

[readalot]

SteroidPlotter cites that study in reaching their PK numbers.

I guess the steroid plotter guys can't read. From the paper:

The median post hoc half-life was calculated to be 4.05 days for tT.

 

[readalot]

@lift4lyfe

If you want to estimate the number from Table 2 in the paper:

For those who are struggling on TRT

I've been thinking about this thread lately. Any theories on why you seem to respond better on 1x week versus daily? I've read a number of accounts from med-high SHBG guys like you who do better on less frequent injections. I think it’s just the simple mechanism of the medication itself and...

www.excelmale.com

3.4 to 4.4 days.

 

[Benf15harp]

SteroidPlotter is for entertainment purposes only.

 

[lift4lyfe]

Theoretically, yes. In practice, not much...

https://forums.steroid.com/attachments/hormone-replacement-therapy-low-testosterone-treatment-anti-aging/168098d1488661137-1-2-life-testosterone-myth-injecting-every-2-weeks-better-t-cyp-kinetic-curve-2.png

Forgive me for not pulling this from original reference. Don't have that pdf handy at the moment. I am familiar with the figure though.

It seems Kurt heard us discussing the TE vs TC structure and how TC has a cyclic ring that decreases peak serum levels (i.e., low Cmax) and increases Tmax. Thus, Kurt says TC is not effective outside of TRT. Listen to what he says for a few minutes:


View: https://www.youtube.com/live/ssG11LLZptY?t=3629&si=sbdaG-nmv2QqtFJl

 

[readalot]

It seems Kurt heard us discussing the TE vs TC structure and how TC has a cyclic ring that decreases peak serum levels (i.e., low Cmax) and increases Tmax. Thus, Kurt says TC is not effective outside of TRT. Listen to what he says for a few minutes:


View: https://www.youtube.com/live/ssG11LLZptY?t=3629&si=sbdaG-nmv2QqtFJl

Thanks for sharing. I listened to it and respectfully it is silly. No offense to you. Nonsensical comments. He uses words such as chemistry and calculus like some of us gearheads don't grasp these concepts. In the limit of continuous infusion there can't be any difference in serum levels for TC vs TE corrected for %T in the ester. In practice, you just dose every day if you want stable blood levels. You can move Cavg by increasing dose. No magical differences between TE vs TC.

The Minto study is well covered on the forums but often misunderstood. AUC is similar for NPP vs ND (IIRC that study did have a difference in AUC for some of the sites/prodrug cases). You can see on that famous plot that NPP peaks higher then falls off faster for a single bolus Again, if you dosed NPP vs ND every day, no real difference on serum Nandrolone levels vs time. So not sure how Kurt is messing up these basic pharmacokinetic principles.