Miripex - pramipexole

[zkt]

Why would this D2 receptor agonist cause sleepiness? This is a side effect of L-dopa, also a D receptor agonist. Seems to me it should perk you up.

 

[imrj]

i thought dopamine has this type of effect on its own? and that its only when it turns into norepinephrine that it turns activating....I can tell this difference between when I take Vyvanse (pure dexamp) and Adderall (dex-amp and lev-amp)

 

[CubbieBlue]

Good question and something I want to bring up with my doctor. I think it varies on the individual. This is something I may be trying in the near future.

 

[mrmorris]

I personally never heard of this drug. But here are some of the side effects, if you are currently on it.

Pramipexole may cause side effects.

abnormal body movements and motions

weakness

dizziness

drowsiness

difficulty falling asleep or staying asleep

difficulty remembering or thinking

confusion

abnormal thoughts or dreams

heartburn

constipation

diarrhea

loss of appetite

weight loss

dry mouth

joint pain

frequent urination or urgent need to urinate

difficulty urinating or pain when urinating

decreased sexual interest or ability

swelling of the arms, hands, feet, ankles, or lower legs


Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

hallucinations (seeing things or hearing voices that do not exist)

changes in vision

chest pain

shortness of breath

dark, red, or cola-colored urine

muscle tenderness

muscle stiffness or aching

muscle weakness

Heres some more info on it.

By acting as an agonist for the D2, D3, and D4 dopamine receptors, pramipexole may directly stimulate the underfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia.

So yes zkt your right why would it cause sleepiness, when it like you said and just above states that it should directly stimulate the underfunctioning Dopamine receptors in the striatum!

Well I guess as stated in the side effects of this drug that drowsiness is a common side effect, I guess It just depends on the person, everyone reacts differently. I love how also states above in the side effect list that it may also cause difficulty falling asleep or staying asleep.

So hell I guess it just depends on the person?????????

Thanks, mrmorris!

Why would this D2 receptor agonist cause sleepiness? This is a side effect of L-dopa, also a D receptor agonist. Seems to me it should perk you up.

 

[zkt]

As I understand it DA is the neurotransmitter most closely associated with alertness, but D receptors are widely spread thru theout body and there are a lot of types with different effects.
For sure Epi, NE and DA are very similar structurally and are somewhat interconvertable. As for the dextro and levo: these chemicals are 3 dimentional as compared to a water molecule, fer instance, which is 2D. Any given 3D molecule can have 2 structures- just like a right hand and a left hand do. They are identicall as far as their constituants and structure go- but they are mirror images of each other and as such not have the same bioactivity. The L form of amino acids and the D form of sugars (primarily glucose) are usually the biologically reactive form.
Here is the big picture:

[ame="http://en.wikipedia.org/wiki/Isomer"]Isomer - Wikipedia, the free encyclopedia@@AMEPARAM@@/wiki/File:Isomerism.png" class="image"><img alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Isomerism.png/500px-Isomerism.png"@@AMEPARAM@@commons/thumb/7/7f/Isomerism.png/500px-Isomerism.png[/ame]

[ame="http://en.wikipedia.org/wiki/Levorotation_and_dextrorotation"]Levorotation and dextrorotation - Wikipedia, the free encyclopedia[/ame]

[ame="http://en.wikipedia.org/wiki/Racemization"]Racemization - Wikipedia, the free encyclopedia@@AMEPARAM@@/wiki/File:Question_book-new.svg" class="image"><img alt="Question book-new.svg" src="http://upload.wikimedia.org/wikipedia/en/thumb/9/99/Question_book-new.svg/50px-Question_book-new.svg.png"@@AMEPARAM@@en/thumb/9/99/Question_book-new.svg/50px-Question_book-new.svg.png[/ame]

i thought dopamine has this type of effect on its own? and that its only when it turns into norepinephrine that it turns activating....I can tell this difference between when I take Vyvanse (pure dexamp) and Adderall (dex-amp and lev-amp)

 

[mrmorris]

I see, that really lays it out!

As I understand it DA is the neurotransmitter most closely associated with alertness, but D receptors are widely spread thru theout body and there are a lot of types with different effects.
For sure Epi, NE and DA are very similar structurally and are somewhat interconvertable. As for the dextro and levo: these chemicals are 3 dimentional as compared to a water molecule, fer instance, which is 2D. Any given 3D molecule can have 2 structures- just like a right hand and a left hand do. They are identicall as far as their constituants and structure go- but they are mirror images of each other and as such not have the same bioactivity. The L form of amino acids and the D form of sugars (primarily glucose) are usually the biologically reactive form.
Here is the big picture:

Isomer - Wikipedia, the free encyclopedia

Levorotation and dextrorotation - Wikipedia, the free encyclopedia

Racemization - Wikipedia, the free encyclopedia

 

[imrj]

As I understand it DA is the neurotransmitter most closely associated with alertness, but D receptors are widely spread thru theout body and there are a lot of types with different effects.
For sure Epi, NE and DA are very similar structurally and are somewhat interconvertable. As for the dextro and levo: these chemicals are 3 dimentional as compared to a water molecule, fer instance, which is 2D. Any given 3D molecule can have 2 structures- just like a right hand and a left hand do. They are identicall as far as their constituants and structure go- but they are mirror images of each other and as such not have the same bioactivity. The L form of amino acids and the D form of sugars (primarily glucose) are usually the biologically reactive form.
Here is the big picture:

Isomer - Wikipedia, the free encyclopedia

Levorotation and dextrorotation - Wikipedia, the free encyclopedia

Racemization - Wikipedia, the free encyclopedia

but I believe like pure dextroamp (ie. Dexedrine/Vyanse) targets dopamine mostly and the levoamp targets SNS via norepinephrine...took the below from wikipedia....the Dexedrine alone actually gives me some relaxation and "feel good" sense...but man if I have to get shit down it has to be Adderall....I've read many people need the levoamp kick in the pants to work

Levoamphetamine is the levorotary stereoisomer of the amphetamine molecule. It possesses much weaker dopaminergic activity than the dextrorotary isomer (dextroamphetamine) and acts as a selective releasing agent of norepinephrine, similarly to levomethamphetamine.

 

[mrmorris]

Hell I love my Adderall my (Stimulant Med) it helps with my ADD a ton, and stimulates the hell out of my brain. Keeps me focus, moving, getting things done, I love it, it's my multi propose drug, J/K[)]

Other than that I am not too much interested in it.

But on the Mirpex - pramipexole, the last guy that posted, what he said does make some logical sence, I think.

mrmorris!