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partial androgen insensitivity guy

Efficacy and safety of high dose testosterone therapy in partial androgen insensitivity

He responded poorly to low dose exogenous androgen and underwent multiple genital reconstructive operations. He was then lost to follow up. On representation in Aberdeen at the age of 27 years his T was 38nmol/l, FSH 3.7u/l, LH 12u/l and oestradiol 240pmol/l. He commenced Sustanon IM weekly injections, initially 250mg for 2 months and then 500mg for 2 years. He has shown significant increase in libido, development of facial and body hair and deepening of voice. His current T is 120nmol/l, FSH 1u/l, LH 3.6u/l and oestradiol 170pmol/l. Lipid profile and haematocrit have remained normal throughout.

His T was 38 and LH was 12. My T was 30.5 and LH 13 and this after abusing roids for years. He has PAIS. I have MAIS.
 
Re: partial androgen insensitivity guy

Efficacy and Safety of High Dose Testosterone Therapy in Partial Androgen Insensitivity

S. Bandyopadhyay, W.A.Watson, C. M.Park, P. Abraham, S. Philip, S. Acharya , J.S. Bevan. Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN.

INTRODUCTION: There have been few reports of the efficacy and safety of high dose androgen therapy in men with partial androgen insensitivity (PAI). We report on the responses of a patient carrying an androgen receptor (AR) mutation predicted (in vitro) to be overcome by high testosterone (T) concentrations.

CASE REPORT: This 29 year old patient had ambiguous genitalia at birth but was found to be 46 XY. He had a small, hypospadiac penis with underdeveloped bifid scrotum. There was no significant family history. After puberty he developed female secondary sexual characteristics. He responded poorly to low dose exogenous androgen and underwent multiple genital reconstructive operations. He was then lost to follow up. On representation in Aberdeen at the age of 27 years his T was 38nmol/l, FSH 3.7u/l, LH 12u/l and oestradiol 240pmol/l. He commenced Sustanon IM weekly injections, initially 250mg for 2 months and then 500mg for 2 years. He has shown significant increase in libido, development of facial and body hair and deepening of voice. His current T is 120nmol/l, FSH 1u/l, LH 3.6u/l and oestradiol 170pmol/l. Lipid profile and haematocrit have remained normal throughout.

DISCUSSION: He was previously shown to have a Serine to Glycine substitution at position 703 in exon D of the androgen receptor ( Prof. I.A.Hughes, Cambridge).We have demonstrated the in-vivo efficacy of pharmacological doses of testosterone in overcoming this AR defect. Significant falls in LH/FSH confirmed negative feedback at pituitary level. High dose Sustanon was well-tolerated with no adverse changes in cardiovascular risk factors.
 
Re: partial androgen insensitivity guy

Efficacy and Safety of High Dose Testosterone Therapy in Partial Androgen Insensitivity

S. Bandyopadhyay, W.A.Watson, C. M.Park, P. Abraham, S. Philip, S. Acharya , J.S. Bevan. Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN.

INTRODUCTION: There have been few reports of the efficacy and safety of high dose androgen therapy in men with partial androgen insensitivity (PAI). We report on the responses of a patient carrying an androgen receptor (AR) mutation predicted (in vitro) to be overcome by high testosterone (T) concentrations.

CASE REPORT: This 29 year old patient had ambiguous genitalia at birth but was found to be 46 XY. He had a small, hypospadiac penis with underdeveloped bifid scrotum. There was no significant family history. After puberty he developed female secondary sexual characteristics. He responded poorly to low dose exogenous androgen and underwent multiple genital reconstructive operations. He was then lost to follow up. On representation in Aberdeen at the age of 27 years his T was 38nmol/l, FSH 3.7u/l, LH 12u/l and oestradiol 240pmol/l. He commenced Sustanon IM weekly injections, initially 250mg for 2 months and then 500mg for 2 years. He has shown significant increase in libido, development of facial and body hair and deepening of voice. His current T is 120nmol/l, FSH 1u/l, LH 3.6u/l and oestradiol 170pmol/l. Lipid profile and haematocrit have remained normal throughout.

DISCUSSION: He was previously shown to have a Serine to Glycine substitution at position 703 in exon D of the androgen receptor ( Prof. I.A.Hughes, Cambridge).We have demonstrated the in-vivo efficacy of pharmacological doses of testosterone in overcoming this AR defect. Significant falls in LH/FSH confirmed negative feedback at pituitary level. High dose Sustanon was well-tolerated with no adverse changes in cardiovascular risk factors.

That's why he's been diagnosed with 'Partial androgen insensitivity syndrome' because he's not fully masculinised. I've been diagnosed with 'Mild Androgen Insensitivity Syndrome' by the best AIS doctor in the world.

MAIS is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia is that of a normal female, mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia is that of a normal male, and partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia is partially, but not fully masculinized

MAIS is only diagnosed in normal phenotypic males, and is not typically investigated except in cases of male infertility . MAIS has a mild presentation that often goes unnoticed and untreated; even with semenological, clinical and laboratory data, it can be difficult to distinguish between men with and without MAIS, and thus a diagnosis of MAIS is not usually made without confirmation of an AR gene mutation . The androgen sensitivity index (ASI), defined as the product of luteinizing hormone (LH) and testosterone (T), is frequently raised in individuals with all forms of AIS, including MAIS, although many individuals with MAIS have an ASI in the normal range [5]. Testosterone levels may be elevated despite normal levels of luteinizing hormone [15][20][24]. Conversion of testosterone (T) to dihydrotestosterone (DHT) may be impaired, although to a lesser extent than is seen in 5?-reductase deficiency [3]. A high ASI in a normal phenotypic male [45], especially when combined with azoospermia or oligospermia [5][7], decreased secondary terminal hair [26], and / or impaired conversion of T to DHT [3], can be indicative of MAIS, and may warrant genetic testing.
 
Re: doctors

What was the diagnosis and treatment? Do you have the studies done at the time?

He didn't diagnose me with anything. My T level was 644 at 1:30 pm and LH was 11.4, It was Crisler I went to see and he ordered me these tests. It was a few months later I found out about MAIS and Structure was the man who saw my bloodwork i posted on here and helped me get to where I am today. If it wasn't for him; I'd still be left in the dirt.
 
Re: chopping off my balls

Is this the raving of a drunken mind, a desperate plea for help, or a childish demand for attention ?
 
Re: chopping off my balls

Do you think the NHS will help me if I chop my balls off?

Why don't you chop your hands off, so you can't drink anymore.

9862

It must be the weekend

Is this a UK thing!

ShowLetter.jpg
 
my trt dosage

250 mg test enanthate every 5 days, 0.5 mg anastrozole twice a week and 250 iu hcg twice a week if needed. Don't give me any crap about side effects because:

A - You don't know me
B- I need higher levels of test
C- I have MAIS
 
Re: my trt dosage

[ame=http://www.youtube.com/watch?v=aecXLaY-6dY]NAS - Let there be the light featt Tre Williams - YouTube[/ame]
 
Re: my trt dosage


Yeah, check check, testing
It's clear out there? Yeah
It's like I'm hang gliding over the hood, ha
Never worry (ohhh, no, no, no)

[Verse 1]
Check, let there be light
No gang banging in New York tonight
Just murals of Biggie Smalls, bigger then life
Turn up the kid mic cuz ya'll ain't listening right
What's all this talk that Nas got bought?
I'd rather outline my body in white chalk
Ain't nobody been where I been, they at a stand still
This is all overseen by my man Will

[Chorus: Tre Williams]
As I walk through the shadow of death
I know that I ain't got much time left
And they don't really wanna see the good in me
Ain't satisfied until they see the fool in me
(And I) I know my business, so my sins great
(And I) I thank the hood for all the love they gave
(And I) Forgive 'em all, they did they best to hate
Oh, let there be light

[Verse 2]
This ain't the glorified, just painting the street picture
There's no God in sir Bibles, just blunt and switches
Gillettes cut pain in kitchen
Now every rapper wanna claim he hang with Kenneth "Supreme" Griffith
It's like the same difference cept when niggaz get arraigned
They don't want the same sentence, niggaz get to snitchin
If I could reverse the monsters and turn forward the razas
And bring back the niggaz who was livest
Old hustlers, reminscing on better days
They home, doing nothing, might as well be in a cage
Hating on young brothers, one foot in the grave
They used to love us till we found our own way thru the maze
New York, set trippin and flaggin
Got the West Coast laughing, now Esco's asking
What happened? My homegirl from upper Manhattan
She remembers the quarters that's Latin, alotta rat-a-tat-tatting

[Chorus]

[Verse 3]
The son of the audio cassette era, tech wearer
Bullets and begets, Binzbo's speaker terror
Till man I get mine till I'm dead, so I can drive sumpthin red
Like that horse standing on it's hind legs
Since Arnold and Willis in they bunk beds
I wanted bread like Wonder, not manned-a-wanno like the parent of Lionel
Nas is the Ghetto American Idol
No matter what you do you're never getting my title
I can't sound smart cuz ya'll'll run away
They say I ain't hungry no more and I don't talk about 'ye
Like there's no other way for a ex-hustler
Cake ya, the x-ray splitter to touch ya, I beg to differ
When you're four years into the game, we can have a conversation
Eight years in the game, I invite ya on vacation
Ten years in the game, after I've enjoyed my fame
Only then I let ya pick my brain, niggaz

[Bridge: Nas + (Tre Williams)]
(And I) Right about now (And I) (They don't really know)
(And I) (They don't really see) I don't even deal with all that garbage
(No, no, no) We getting real right, ya know?
(And I) (Though I walk through the valley) That is Tre Williams ladies and gentlemen
(And I) (They should fear no) (And I) (no, no-oh)
Focus on good things man, good times, Heh-heh, alright

[Chorus - 2X (with alterations)]

Oh let it be, let it be, yeah
Let it be, let it be
 
Re: my trt dosage

If I wait 5 years for health insurance for pre exisitngs I will have to wait so that in those 5 years this will no longer be a pre existing. I'm go to self treat until I get private help.

250 gm Test Enantthate every 5 days. I'll be monitoring blood pressure and glucose levels daily. Discarding a pint of blood every 3 months, getting blood tests every 4-6 months, a psa every 6 months and digital rectal exam once a year.

Once I've been doing this for 5 years then I'm going to get private health insurance and will go back to Dr Conway the AIS specialist who diagnosed me or even Professor Bouloux (the best endo in the world) who knows about AIS and how to treat it. I'll also get the genetic test done.
 
Re: partial androgen insensitivity guy

For this guy High dose 500mg weekly Sustanon was well-tolerated with no adverse changes in cardiovascular risk factors.

So who's to say thst high dose test won't fuck me up either?

Supraphysiological doses of testosterone have been shown to correct diminished secondary sexual characteristics in men with MAIS , as well as to reverse infertility due to low sperm count. As is the case with PAIS, men with MAIS will experience side effects from androgen therapy (such as the suppression of the hypothalamic-pituitary-gonadal axis) at a higher dosage than unaffected men.

Supraphysiological doses may be required to achieve the desired physiological effect, which may be difficult to achieve using non-injectable testosterone preparations. Exogenous testosterone supplementation in unaffected men can produce various unwanted side effects, including prostatic hypertrophy, polycythemia, gynecomastia, hair loss, acne, and the suppression of the hypothalamic-pituitary-gonadal axis, which results in the reduction of gonadotropins (i.e., luteinizing hormone and follicle-stimulating hormone) and spermatogenic defect. These effects may not manifest at all in men with AIS, or might only manifest at a much higher concentration of testosterone, depending on the degree of androgen insensitivity[/quote]
 
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the reason for 300 mg trt threads

This why I start thread about taking doses of 250 - 300 mg Test a week as TRT:
https://thinksteroids.com/community/posts/799114

I'm not a normal need to be in the range of 600 - 800 ng/dl guy. My endo who I was referred to by the best AIS doctor in the world even said to me. 'Maybe you do need a higher level of testosterone'.
 
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