Triptorelin to Restore HPTA

extralarge

New Member
I see this article of a sponsor and in a later search i found on a forum a personal story of usage of this med.

What you guys think?

We are excited to be able to bring to the market a new research peptide that that stimulates the hypothalamus to secrete GnRH into the hypophysial portal bloodstream which results in the activation of proteins involved in the synthesis and secretion of the gonadotropins LH and FSH.

In males LH (Luteinizing hormone) stimulates Leydig cell production of testosterone.

In males FSH (Follicle-stimulating hormone) stimulates the maturation of seminiferous tubules and spermatogenesis.

We think this is revolutionary. Why?

In the past the options may have been clomiphene and tamoxifen. There is a significant amount of research today that illuminates the following side-effects of those SERMs: low libido, erectile dysfunction, emotional instability, ocular toxicity and hepatocellular carcinoma- just to name a few.

The other option may have been HCG. A fine option. But one that requires a very specific daily protocol, and a protocol that if not followed in a disciplined manner, may damage the endocrine system further.

Besides, GnRH is a naturally occurring neurohormone. The body does not produce clomiphene citrate, tamoxifen or *HCG naturally (*unless you are pregnant).

The problem with GnRH in the past has been that in order for it to effectively exert its actions upon the pituitary gland, several pulses over several days would need to be stimulated. These required an infusion pump in many cases. Or if too much GnRH was given it would eventually decrease pituitary secretion of gonadotropins.

After several agonists and analogues of GnRH later- we now have Triptorelin.

The research peptide Triptorelin is a decapeptide that is modeled after the hypothalamic neurohormone GnRH, that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH.

We have found the exact amount of Triptorelin (100mcg) to administer to stimulate the release of LH and FSH and at the same time not overexert its effects on the pituitary gland.

That is one-singular injection of Triptorelin (100mcg) to completely restore endocrine function! One and done!!!

The protocol is found in the Triptorelin test that is used clinically to diagnose disease of the endocrine system. Below is the medical abstract that illustrates the success of this peptide in restoring endocrine function:

Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism

Objective
To report a case of hypogonadotropic hypogonadism due to the chronic abuse of anabolic steroids purchased over the Internet.

Design
Case report.

Setting
Endocrinology unit of the University of Brescia.

Patient(s)
A 34-year-old man.

Intervention(s)
A single dose (100 ***956;g) of triptorelin (triptorelin test).

Main Outcome Measure(s)
Clinical symptoms, androgen normalization, levels of serum testosterone, follicle-stimulating hormone, and luteinizing hormone.

Result(s)
Within 1 month, the patient's serum testosterone was in the normal range, and he reported a return to normal energy and libido.

Case report
A 34-year-old man presented to our department in September 2008 for loss of libido and energy and for mild depression. He was a computer programmer and a nonprofessional bodybuilder with an unremarkable personal medical history. He admitted to having used doping drugs since he was 21 years old. More specifically, he would perform cycles of intramuscular injections of nandrolone (25 mg) and stanazol (25 mg) daily for 8 weeks, followed by mesterolone (50 mg/day) for 15 days. Then he would then take clomiphene citrate (50 mg/day) for 1 week, followed by an injection of human chorionic gonadotropin (2,000 IU) three times in 1 week. He had repeated these cycles from 1995 to 2005. From 2005 to August 2008, to his nandrolone and stanazol cycle he added an intramuscular injection of boldenone (50 mg) daily for 3 weeks. He said he had bought all the drugs on the Internet.

The patient was 175 cm tall and 80 kg, and he appeared very muscular and toned. His blood pressure and pulse rate were normal. Examination of his heart, lungs, and abdomen were likewise unremarkable. The physical examination showed normal secondary sexual characteristics, but the genital examination revealed bilateral testicular atrophy (volume 2.9 mL and weak consistence). Despite his testicular atrophy, the semen analysis revealed a normal count (79 × x106spermatozoa/mlmL) and mild morphology derangements (between 46% and 58%). The blood count and chemistry were normal, but his level of creatine kinase was 454 IU/L (normal range: 20--170 IU/L), alanine aminotransferase 61 IU/L (normal range: 5--50 IU/L), and aspartate aminotransferase 23 IU/L (normal range: 5--50 IU/L).

In February 2009, the patient continued to report loss of libido and great tiredness. A second physical examination was performed. His levels of alanine transferase and creatine kinase were all within the normal range, but the endocrinologic investigations were still abnormal with the exception of sex hormone-binding globulin level. *The patients testosterone measured 0.3 ng/mL - normal range is between 2.0 ng/mL and 12 ng/ML. Because the situation had persisted for months after ASS withdrawal, we administered a single dose (100 ***956;g) of triptorelin (triptorelin test), which showed a normal response (Fig. 1). Ten days after the triptorelin test, the patient reported a great amelioration of energy, and his serum testosterone was 7.0 ng/mL. One month later, his serum testosterone was within the normal range, and he reported a return to normal libido and energy.

"Hey guys I've been working with a HRT doc to try and get my test up. I'm 25 and have been in the low 300's for total test for years. Docs all told me I was within normal ranges for years until I came to know better. My doc put me on a clomid protocol for about 5 month with very little response. My numbers came up a little bit. He then gave me a shot of Triptorelin. That's what brought me here. I wanted to learn and understand more about what he gave me. I'm not sure of the dose, i would guess it's the 100mcg that I'm reading about that seems to be most common for this treatment.

When I first came to this Dr. my total T was 328. The clomid brought it up some; I was still in the lower 25 percentile. 3-4 weeks after the Triptorelin shot, I got my blood drawn again, now my Total T is 728. Both my bioavailable and free T is above normal ranges. The bioavailable T is 100 points over the top range.

The shot cost $75. My moods are a lot better, my energy is pretty darn good; I don't feel like napping all the time, and I don't feel as depressed. I don't have a crazy labido or feel super duper now, i feel normal again and its nice. So now, 5 weeks from the shot, the deal is to see if my body keeps these level up. Since all you guys were wondering about real world results with lab work. I hope this helps. "
 
The use of a GnRH agonist (and discussion) for AIH on Meso:

https://thinksteroids.com/community/posts/709181

https://thinksteroids.com/community/posts/747280

https://thinksteroids.com/community/posts/700315

https://thinksteroids.com/community/posts/664779


These are two case reports on use of a GnRH agonist.


Pirola I, Cappelli C, Delbarba A, et al. Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism. Fertil Steril 2010;94(6):2331 e1-3. http://www.fertstert.org/article/S0015-0282(10)00503-0/abstract (Elsevier)

OBJECTIVE: To report a case of hypogonadotropic hypogonadism due to the chronic abuse of anabolic steroids purchased over the Internet.

DESIGN: Case report.

SETTING: Endocrinology unit of the University of Brescia.

PATIENT(S): A 34-year-old man.

INTERVENTION(S): A single dose (100 mug) of triptorelin (triptorelin test).

MAIN OUTCOME MEASURE(S): Clinical symptoms, androgen normalization, levels of serum testosterone, follicle-stimulating hormone, and luteinizing hormone.

RESULT(S): Within 1 month, the patient's serum testosterone was in the normal range, and he reported a return to normal energy and libido.

CONCLUSION(S): The World Anti-Doping Code has proved to be a very powerful and effective tool in the harmonization of antidoping efforts worldwide, but it is insufficient to combat this illegal phenomenon. To tackle the serious side effects caused by doping we believe that it is necessary to increase monitoring and adopt severe sanctions, particularly with regard to Internet sites.


van Breda E, Keizer HA, Kuipers H, Wolffenbuttel BH. Androgenic anabolic steroid use and severe hypothalamic-pituitary dysfunction: a case study. Int J Sports Med 2003;24(3):195-6. https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-39089

The data of the present case demonstrate that the abuse of androgenic anabolic steroids (AAS) may lead to serious health effects. Although most clinical attention is usually directed towards peripheral side effects, the most serious central side effect, hypothalamic-pituitary-dysfunction, is often overlooked in severe cases. Although this latter central side-effect usually recovers spontaneously when AAS intake is discontinued, the present case shows that spontaneous recovery does not always take place. We suggest that hypothalamic-pituitary dysfunction should always be considered in the differential diagnosis in athletes seen with typical presentation of anabolic steroid use. In order to regain normal hypothalamic-pituitary function, supraphysiological doses of 200 microg LH-RH should be considered when the physiological challenge test with LH-RH (50 microg) fails to show an acceptable response.
 
The use of a GnRH agonist (and discussion) for AIH on Meso:

https://thinksteroids.com/community/posts/709181

https://thinksteroids.com/community/posts/747280

https://thinksteroids.com/community/posts/700315

https://thinksteroids.com/community/posts/664779


These are two case reports on use of a GnRH agonist.


Pirola I, Cappelli C, Delbarba A, et al. Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism. Fertil Steril 2010;94(6):2331 e1-3. http://www.fertstert.org/article/S0015-0282(10)00503-0/abstract (Elsevier)

OBJECTIVE: To report a case of hypogonadotropic hypogonadism due to the chronic abuse of anabolic steroids purchased over the Internet.

DESIGN: Case report.

SETTING: Endocrinology unit of the University of Brescia.

PATIENT(S): A 34-year-old man.

INTERVENTION(S): A single dose (100 mug) of triptorelin (triptorelin test).

MAIN OUTCOME MEASURE(S): Clinical symptoms, androgen normalization, levels of serum testosterone, follicle-stimulating hormone, and luteinizing hormone.

RESULT(S): Within 1 month, the patient's serum testosterone was in the normal range, and he reported a return to normal energy and libido.

CONCLUSION(S): The World Anti-Doping Code has proved to be a very powerful and effective tool in the harmonization of antidoping efforts worldwide, but it is insufficient to combat this illegal phenomenon. To tackle the serious side effects caused by doping we believe that it is necessary to increase monitoring and adopt severe sanctions, particularly with regard to Internet sites.


van Breda E, Keizer HA, Kuipers H, Wolffenbuttel BH. Androgenic anabolic steroid use and severe hypothalamic-pituitary dysfunction: a case study. Int J Sports Med 2003;24(3):195-6. https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-39089

The data of the present case demonstrate that the abuse of androgenic anabolic steroids (AAS) may lead to serious health effects. Although most clinical attention is usually directed towards peripheral side effects, the most serious central side effect, hypothalamic-pituitary-dysfunction, is often overlooked in severe cases. Although this latter central side-effect usually recovers spontaneously when AAS intake is discontinued, the present case shows that spontaneous recovery does not always take place. We suggest that hypothalamic-pituitary dysfunction should always be considered in the differential diagnosis in athletes seen with typical presentation of anabolic steroid use. In order to regain normal hypothalamic-pituitary function, supraphysiological doses of 200 microg LH-RH should be considered when the physiological challenge test with LH-RH (50 microg) fails to show an acceptable response.

I try many PCT's and stay out of AA use for one year. In the end of one year, when i made blood tests, the results were the same.. Low Test, LH and FSH. Low Estradiol, Prolactin in the maximum range and Progesterone a little bit higher than maximum range! I saw diferent doctor's and no one wants to treat me, just said me to stay out of AAS and MAYBE in a few years my endocrine system may be restored!!
The last Dr. i see put me on TRT but i think the dosage is weak and i don't come back to his officer until now.

LHRH can be a option to me?
And what about Triptorelin should i try it?


i'm just 25 and i don't find no one to help around here so i need sugestions...
 

I'm not sure if is the same API but is for the same purpose.
Where i live i find a few diferent substances for this purpose (GnRH agonist):

BUSERELINE
GOSERELINE
LEUPRORELINE
TRIPTORELINE

The Triptoreline is the one i see in the study and it seems to be a very controversial substance when used to treat hipogonadism. i found on web 2 cases of hipogonadism that Docs give it a try to this substance to restore endocrine system. i found no studies to prevent downregulation of HPTA during a AAS cycle.

On the 2 cases i have read, Docs give a single shot of 100mcg just to estimulate an restart of gonadotropins. and seems that works..
i'm not an expert on this subject but what i understand is that this medication are created not for this purposes.. they are made to use with higher doses ( MG ) and frequently, to over estimulate the release of gonadotropins and with this over estimulation, your testosterone will be reduced. (in the label says that cautions must be taken because an initial raise in Testosterone will occur while the over estimulation doesnt occur). With this said, seems to be some truth with off label aplication.
When used for off label purposes they use not in MG doses and not frequently! they just use a single shot of 100 MCG (not MG). and that will just estimulate a little bit the release of gonadotropins and that seems the secret of this method. More studies on this need to be made but it's kind of logic.
What is talked in a few forums on web is that the rest of medical comunity it's against this method since the medication was not created for this purpose; theres no interest in restore endocrine function of bodybuilder because if the athletes knows that is a cure for ASIH they will abuse even more on AAS; because bodybuilders will not look for doctors any more to solve their endocrine problems; and because is a lot of money applied on research for miracle meds for treatment of ASIH.

What it's the real truth and if this method real works?
i wish i know....

i also wish that medical comunity study more if there's a possibility for this off label aplication be use in a near future instead of just saing that it's not the way we should look at since the med is made for other purposes..
We all know that for years, bodybuilders was one step a head of medical comunity, when all doctors said that AAS do not increase strenght or enhance muscle hipertrophy and the bodybuilders was proven the opposite.
 
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