5 weeks into retatrutide

[thedon966]

Just wanted to give my retatrutide experience, this is my current dosing:

week 1: 2mg
week 2: 2mg
week 3: 3.5mg
week 4: 4mg
week 5: 4mg

first two weeks didn't notice a single thing still binged for 3 days lol
week 3 still didn't notice anything major but I didn't binge I still could binge if I really wanted to
week 4 is when I had one day of really bad bloating that lasted for a half a day and went away. I believe I did start noticing an appetite suppression but I could still cheat but the desire to binge or eat out wasn't totally there.
week 5 I don't really have a desire to eat junk and have been sticking to a diet pretty well. No bloating.

while taking reta I've also been tracking blood sugar via cgm and even when I did cheat, my blood sugar never got above 120(and your boy ate). Could be because I'm post show but even week 3-4 with high carb meals It NEVER goes over 120. I'm eating more food now in my diet and the highest it gets to now is 109-111 at peak spike and quickly goes down within minutes. I'd say I need to run reta a little longer to make a final answer and maybe even up the dose but I'll keep this thread updated.

 

[Tawny]

Many suggest if you feel nothing after two weeks to jump up.

Serious question, cause of your name, are you Male or Female? Heard doses affect gender differently too.

I am a female currently using Tirz. I believe I was a super responder to Tirz, but now it’s mundane. I have ISR also. I tried Reta at 2mg and the first time had a ISR so I don’t know. It’s gotten better, but I feel like the meds have quit working.

 

[Strongerhope]

Any heart issues?

I'm curious if you've noticed any heart issues on reta so far? That's the only reason I'm scared to try reta

Ive read the people who have this usually titrate too quickly.

 

[Ghoul]

I am a female currently using Tirz. I believe I was a super responder to Tirz, but now it’s mundane. I have ISR also. I tried Reta at 2mg and the first time had a ISR so I don’t know. It’s gotten better, but I feel like the meds have quit working.

Immunogenicity....

 

[Sampei]

As anyone of you had very bad bloating on reta? Any explanation of it? I have a friend that is having a really rough day telling me his stomach is bloated as fuck and without any apparent reasons, he didn't even had a cheat meal or anything but he has cramps and just can't eat shit and his stomach is just dilated.

Could this be a sign of gastroparesis? Or it's just crazy bloating?

 

[Ghoul]

As anyone of you had very bad bloating on reta? Any explanation of it? I have a friend that is having a really rough day telling me his stomach is bloated as fuck and without any apparent reasons, he didn't even had a cheat meal or anything but he has cramps and just can't eat shit and his stomach is just dilated.

Could this be a sign of gastroparesis? Or it's just crazy bloating?

Only those with diabetic neuropathy get gastroparisis.

Is he getting bowel movements? Severe constipation can definately develop. particularly as thirst is as inhibited as hunger on a GLP. If he hasn't had a movement in three days he needs a laxative asap.

 

[17SS]

That said, constipation is a possibility with any GLP, and these effects are worst in the first 6 weeks or so.

Personally I only use Metamucil once a day.

I can’t use Metamucil. I’m on the other end of the spectrum. Someone installed a straight pipe in my gut somewhere along the way. Oddly enough the rest of my immediate family is the opposite. I guess I got the recessive straight pipe poop gene.

Yes, I get colonoscopies.

 

[Here2Learn]

Immunogenicity....

Did you see in the new study they are conducting taking Reta vs Tirz with no placebo? In the guidelines you can have used any GLP prior to starting but it must have been at least 90 days and your weight has to have been steady within that time frame. Makes me think there isn’t as much immunogenicity being found.

 

[Ghoul]

Did you see in the new study they are conducting taking Reta vs Tirz with no placebo? In the guidelines you can have used any GLP prior to starting but it must have been at least 90 days and your weight has to have been steady within that time frame. Makes me think there isn’t as much immunogenicity being found.

I would not expect any pharma protein therapeutic the FDA has approved, whether as a marketed drug, or for clinical trials, to demonstrate problematic immunogenicity. Extensive computer simulations, in vitro petri dish testing on cells, and finally in vivo animal tests must all point to a low level of immunogenicity before the first small group of human subjects can be injected.

By that point immunogenicity has been wrung out of the product from initial development, manufacturing, excipient selection, and packaging.

In fact, if any of those elements changes, a lack of problematic immunogenicity must be demonstrated to the FDA all over again. Something as simple as changing the material of the plunger in an injection pen.

If you took a peptide, and set out to do everything you could to make it induce the worst possible immunogenic reaction, you'd end up with something similar to UGL peptides.

 

[Tawny]

Immunogenicity....

Is it possible to lose potency? I’m using 7.5mg and feel like it’s not working as well. I’m curious if it has to do with immunity. 30lbs quick, but now nothing. For almost 1 month.

 

[Here2Learn]

I would not expect any pharma protein therapeutic the FDA has approved, whether as a marketed drug, or for clinical trials, to demonstrate problematic immunogenicity. Extensive computer simulations, in vitro petri dish testing on cells, and finally in vivo animal tests must all point to a low level of immunogenicity before the first small group of human subjects can be injected.

By that point immunogenicity has been wrung out of the product from initial development, manufacturing, excipient selection, and packaging.

In fact, if any of those elements changes, a lack of problematic immunogenicity must be demonstrated to the FDA all over again. Something as simple as changing the material of the plunger in an injection pen.

If you took a peptide, and set out to do everything you could to make it induce the worst possible immunogenic reaction, you'd end up with something similar to UGL peptides.

They are excepting those who have been on peptides too, not just those on the FDA approved. We shall see what comes out of it.

 

[Anonymous35]

Is it possible to lose potency? I’m using 7.5mg and feel like it’s not working as well. I’m curious if it has to do with immunity. 30lbs quick, but now nothing. For almost 1 month.

Maybe up the dose 7,5mg isn’t high dose
In those studies they used 5-10 and 15mg/w