I have successfully read the entire 56 page thread. Took me a while...
This has been very eye opening and debunked alot of stuff people used to do cuz they were told to or think is the better option. I am someone who literally strived to split my dosing and strived to get 90mg BG 3 hours post meal to inject my pre-bed HGH, took so much effort, timing, inconvenience to apply and sooo many meds and procedures. I even once did 3 times a day when I first started HGH when going a 10ius blast.
FOUNDATIONAL TRUTHS (Debunked myths)
| Myth | Proven Reality |
|---|
| “GH must be split 3–5× daily for lipolysis” | False — GH lipolysis is peak-driven, not time-under-curve. One large bolus → higher amplitude → more fat mobilization. |
| “Fasted cardio after GH is required for fat loss” | False — GH itself induces fat oxidation; cardio just amplifies it. |
| “1.4 IU maxes out lipolysis” | No — linear effect up to at least 0.1 IU/kg (~8 IU for 80 kg). |
| “You must fast 6–8 h after GH” | Overshot — 2–3 h of low insulin post-injection is sufficient. |
| “Split dosing prevents water retention” | Opposite — split dosing keeps GH/IGF-1 elevated all day → chronic Na⁺ retention and edema. |
| “More frequent shots = better muscle gain” | Only true for collagen/joint repair; muscle hypertrophy depends on total IGF-1, which one large dose can match. |
WHEN TO INTERVENE
| Sign | Likely cause | Fix |
|---|
| Fasting BG > 5.8 mmol for > 1 wk | Excess total exposure / inadequate XR | Increase Metformin XR dose or add Jardiance |
| Persistent edema | Chronic exposure (split dosing) | Switch to single AM, add Eplerenone |
| Poor sleep | Night GH pulse overlap | Move injection to AM |
| Weak lipolysis | Eating < 2 h post-inj. | Delay carbs ≥ 2.5 h |
GH increases peripheral conversion of T4 to T3, may deplete T4.
50 µg T4 on maintenance, 100 µg on higher GH (> 8 IU).
Avoid routine T3; only for short contest preps.
Main TAKEAWAYS (for everyone)
1. One bolus > split dosing for metabolic health.
2. 2–3 h fasting post-GH is all you need — not 6–8 h.
3. Metformin XR alone controls glucose for most users.
4. 8–10 IU morning injection = maximal fat loss & minimal side effects.
5. Always pair GH with T4 support and RAAS / insulin-sensitizer backbone.
6. Stop chasing near-fasting post-meal BG — only intervene > 6.7 mmol.
7. Less is often more: continuous GH exposure creates chronic IR and puffiness without more gains
I think my approach will be as follows:
8–10 IU single morning injection, wait 2.5 h before carbs, Metformin XR at night, T4 support daily. ( I like Jardiance, eplerenone anyways for it's CV support)
