Accutane permanent cure?

[AllbrandNew]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

For me, the sides calmed down some from their peak after titrating up to my next dose each time, but the overall effect seemed to be dose dependent. Overall higher dose= more/more severe sides, but in my exp was not linear, if that makes sense. Like a 50% bump in dosage netted like ~15-20% more severe sides.

The only oddity for me was coming back down and not getting relief.

 

[bigforyouben]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

I'm at 160 mg/day and starting week 6 of my 23,000 mg run. I was thinking if just staying at 160 mg for the remainder of my run if the uncomfortable dryness goes away or, at least, noticeably reduces.

I dropped from 160 to 120 (at about 90kg bodyweight). Sides at 120 have gotten better than when I started 120, but I'm putting Aquaphor lip repair on my lips every hour or two and swabbing my nostrils with Aquaphor healing ointment every night. My lips still crack but not terribly any more. My skin has also got a little less sensitive.

I'm getting US pharma isotretinoin through a dermatology nurse, and he says 120mg is the highest dose he's ever put somebody on, but my bloodwork looks good. I'm at 10k of a 20k cumulative dose and should be done in 3 more months, which I think is manageable with the current sides.

 

[oldage]

I dropped from 160 to 120 (at about 90kg bodyweight). Sides at 120 have gotten better than when I started 120, but I'm putting Aquaphor lip repair on my lips every hour or two and swabbing my nostrils with Aquaphor healing ointment every night. My lips still crack but not terribly any more. My skin has also got a little less sensitive.

I'm getting US pharma isotretinoin through a dermatology nurse, and he says 120mg is the highest dose he's ever put somebody on, but my bloodwork looks good. I'm at 10k of a 20k cumulative dose and should be done in 3 more months, which I think is manageable with the current sides.

1% hydrocortisone lip balm off Amazon is a miracle.

 

[synthetic_juggernaut]

For you guys that were (or still are) at a high-ish dose for a while, does staying at the exact same dose eventually make all of the uncomfortable dryness sides go away? Does the body get used to a certain dose with time and adjust?

I'm at 160 mg/day and starting week 6 of my 23,000 mg run. I was thinking if just staying at 160 mg for the remainder of my run if the uncomfortable dryness goes away or, at least, noticeably reduces.

For me the sides (dry lips, dry eyes) haven't totally gone away, but have gotten much better over a few weeks at the fixed high dose. So yeah, I'd recommend riding it out and running the high dose until you hit the target. I'm still deciding if I go on a long-term microdose after the high dose course to make sure I don't get a recurrence around Test blast/cruise transitions

 

[adrenalytic]

Hey brothers, just checking back in with an update.

@AlexDavis43 Exactly. I’m running a bit over a gram AAS right now, and while doing that, I definitely don’t want to be hammering high doses of accutane, even with a good polypharma protocol in place. Nick’s back is wild to me — the fact he is able to cover that up pretty well on stage is impressive. Still, going to message him a link to this thread and see if he’s getting on board lmao

@imthankful @BendigoShafter @adrenalytic
So I think there’s definitely a point of no return in dosing protocols. There’s definitely a sweet spot. The study where participants dosed between 1.3-2.0mg/kg for a period of 6 months straight had impressive results. I just refuse to believe you can take 300-400mg of this stuff per day. Yes, obviously it will work, and while I think the drugs effect on lipids and liver values is overblown by gen pop and spaz dermatologists, there’s no way that dose is not going to have a significant effect of doing more harm than good in relation to blood work.

At least in the 100-200mg range you get the right balance of a high dose and a good amount of time on the drug when going for 220mg/kg.

I’ve been happy with my approach of high dosing for about 3 months to get a good chunk of cumulative dosage in and now dropping to 40mg per day. After a few days, it’s like I’m not even taking anything. The dryness is so much better and manageable. However, I stand by high dosing throughout to reach that high cumulative dose, and think if you’re planning to reach it at 20mg a day, well, good luck. With those maths, at 250lbs, I would need to do that for 3.5 years and 7 years at 10mg a day lol I’m good.

Awesome to here bro. I'm pretty happy where I am currently on 5k of 22k. No shoulder or back cysts in a month and stomach, chest, biceps are just getting the occassional localized outbreak. Biceps is the most annoying because they're the big cystic bitches, take forever to disappear and leave a welt for what seems like months.