Interesting study from Aging Cell that used rhGH, DHEA and Metformin to reverse biological aging. Not new (2019) but new to me.
Many interesting data points, including this one:
A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months
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Many interesting data points, including this one:
A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months
Reversal of epigenetic aging and immunosenescent trends in humans - PMC
Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we ...
pmc.ncbi.nlm.nih.gov
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