Age Reversal Study from Aging Cell

[OldGHGuy]

Interesting study from Aging Cell that used rhGH, DHEA and Metformin to reverse biological aging. Not new (2019) but new to me.

Many interesting data points, including this one:

A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months

Reversal of epigenetic aging and immunosenescent trends in humans - PMC

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we ...

pmc.ncbi.nlm.nih.gov

Enjoy

 

[iris]

I will have a look later.
Want to know how much gh they were actually given during this trial and how long they were monitored for.
Thank you.

 

[Letits now]

I will have a look later.
Want to know how much gh they were actually given during this trial and how long they were monitored for.
Thank you.

I had to scan it and find that out as well. Looks like 4-5 iu administered 3-4 times a week. Maybe check my math.

 

[Grey Spartan]

While I have ordered some GH to try for sleep at around 2iu a night here is another old article that states elevated IGF-1(and really low levels) increases chances of all cause morbidity.

IGF-1 and Risk of Morbidity and Mortality From Cancer, Cardiovascular Diseases, and All Causes in EPIC-Heidelberg - PubMed

This large population-based prospective study showed that both individuals with lowest and highest levels of circulating IGF-1 were at increased risk of deaths from cancer, CVD, and all causes. For individuals with low IGF-1, the excess risks of death were more pronounced among individuals with...

pubmed.ncbi.nlm.nih.gov

 

[iris]

While I have ordered some GH to try for sleep at around 2iu a night here is another old article that states elevated IGF-1(and really low levels) increases chances of all cause morbidity.

IGF-1 and Risk of Morbidity and Mortality From Cancer, Cardiovascular Diseases, and All Causes in EPIC-Heidelberg - PubMed

This large population-based prospective study showed that both individuals with lowest and highest levels of circulating IGF-1 were at increased risk of deaths from cancer, CVD, and all causes. For individuals with low IGF-1, the excess risks of death were more pronounced among individuals with...

pubmed.ncbi.nlm.nih.gov

Thanks.
I was reading this, because someone's acquaintance is having her IGF-1 monitored, amongst other things.
It's to do with her thyroid. Scary stuff.

Study of almost 400,000 confirms that higher blood levels of IGF-1 are a risk factor for several types of cancer — Cancer Epidemiology Unit (CEU)

www.ceu.ox.ac.uk

 

[Sam312xx]

It sucks that long term high levels of hgh could accelerate aging processes. None of what we have right now is any good for aging reversal, got to wait for the upcoming stuff.

 

[AlexDavis43]

None of what we have right now is any good for aging reversal, got to wait for the upcoming stuff.

Be careful what you wish for. Reversing your gainz? Reversing all the things you learned?

 

[Sam312xx]

Be careful what you wish for. Reversing your gainz? Reversing all the things you learned?

We can write detailed instructions to follow beforehand and get the best of both. The question is whether those instructions would be followed

 

[serkan]

I also want to start with HGH, BPC157 and TB500. Due to various joint problems. But I'm still unsure and a little scared about HGH. I was only planning on injecting 1.5-2 IU. Can anyone recommend a protocol? How long should I inject the peptides?

 

[AlexDavis43]

I also want to start with HGH, BPC157 and TB500. Due to various joint problems. But I'm still unsure and a little scared about HGH. I was only planning on injecting 1.5-2 IU. Can anyone recommend a protocol? How long should I inject the peptides?

If you want to mimic the study, it was 0.015 mg/kg which works out to roughly double your proposed dose. And they did it for 1 year. Imo that's not an unreasonable protocol.

I don't know if it's something the researchers would recommend doing once, once every few years, or continually (but they had to stop the study at 1 year for practical reasons).

 

[serkan]

@AlexDavis43 what would be your recommendation?

 

[serkan]

@Grey Spartan will you use HGH in small amounts?

 

[AlexDavis43]

@AlexDavis43 what would be your recommendation?

To learn a lot more about hGH. The search bar can be a very valuable resource; many members (myself included) have written about their protocols and experiences.