Albuterol dosing for women

[MrRippedZilla]

A couple of key papers to share:
Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. - PubMed - NCBI

A Model-Based Meta-Analysis Evaluating Gender Differences on Blood Flow Responses to Brachial Artery Infusions of Acetylcholine, Albuterol, ATP, Bradykinin, Estradiol, Glyceryl Trinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance P, and Verapamil

The first one is a direct study looking at gender differences in vasodilation/constriction (and blood flow) in response to certain drugs. The second is a model-based analysis looking at the impact of those results in comparison to other papers with similar drugs.

The key point is that women are much more sensitive to beta 2 stimulation with the second paper finding a 253% difference in response to the same dose.
Now, not all vascular beds are the same (they were looking at forearm blood flow specifically) but we don't have any in vivo data on the differences in receptor density between the sexes and in vitro data supports these results (women have greater beta 2 receptor density, etc) so I think it's a safe bet to assume this is practically applicable.

The typical dose for albuterol (re body comp) is 16m/d (4mg 4xday). Women will respond stronger than men so that means 1) they can use a much lower dose for an equal effect and 2) they will be more susceptible to side effects if they choose to go higher anyway (the data confirms that they experience more adverse drug reactions than men).

I usually save these posts for UG but I know there is a more active female community here and this is pretty important when it comes to safe use and stuff

 

[GearGodess]

This is a great post. Thanks for that [emoji6][emoji4] I have always suggested that women start at 4mg and work up to 8mg a day max. I personally find great results with 4mg a day. I like Albuterol much more than its big brother Clen.

 

[MrRippedZilla]

This is a great post. Thanks for that [emoji6][emoji4] I have always suggested that women start at 4mg and work up to 8mg a day max. I personally find great results with 4mg a day. I like Albuterol much more than its big brother Clen.

100% what I recommend as well.

Your experience with clen echos that of many women. Clen has a much stronger binding affinity to beta 2, which means women would be even more sensitive to it vs albuterol. That means that if they're following what is commonly recommended across the net, it's going to be a nasty ride. FWIW, my girls see pretty good results with clen and the dose is never over 0.5mg/kg.

 

[GearGodess]

100% what I recommend as well.

Your experience with clen echos that of many women. Clen has a much stronger binding affinity to beta 2, which means women would be even more sensitive to it vs albuterol. That means that if they're following what is commonly recommended across the net, it's going to be a nasty ride. FWIW, my girls see pretty good results with clen and the dose is never over 0.5mg/kg.

Absolutely, clen and I can only handle a tiny amounts of eachother. Lol... I'm actually never passed my max of 25mcg. Pass 25mcg, I have tried before... I feel super cracked out. Those who claim they do more, are probably using water downed solution.