albuterol experiences anyone?

[skywalk]

I have been reading many good things about albuterol, and it seems like it's a better option vs clen. apparently it's more anabolic, (ref needed) and the absolute kicker is that it can improve your cholesterol profile. you can apparently also take it longer than clen, as the beta 2 down-regulation doesn't occur so fast (ref needed), has a shorter half life (hence you have a little more control) and the side effects are much less dangerous than clen (cardiac hypertrophy)

anyone who has tried both clen and albuterol, could you please share what you experienced? much appreciated, thanks.

 

[Dr JIM]

Anabolic effects of Beta agonists are at best synergistic when combined with AAS in animal models.

I'm unaware of any data which conveys an anabolic benefit from any of these medications in humans however.

Nonetheless beta agonists MAY be useful as "cutting agents" especially when combined with an appropriate diet and if used in moderation to limit side effects.

Albuterol is the better choice IMO primarily because it's half life is a few HOURS (2-4) versus (1-2) DAYS in most studies.

This is particularly important since there are several CASE REPORTS of adverse outcomes in "athletes" whom have used Clen. These include high grade tachycardias to frank heart attacks.

Obviously when these complications do occur your in it "for the long haul" because of the extended half life.

So Albuterol vs Clenbuterol it's a no brainer, Albuterol wins hands down, IMO!

Best regards mate
Jimmy

 

[skywalk]

Albuterol

Chemical Name: Albuterol Sulfate

Drug Class: Beta-Agonist

Albuterol is very closely related to Clenbuterol (often simply called ?Clen?), which has been a drug athletes have been using for literally decades to lose fat. Although it?s typically thought of as only a shorter acting version of Clenbuterol, that?s not 100% correct, and Albuterol actually has some benefits that Clen doesn?t. Just like Clen, Albuterol binds to the beta 2 adrenergic receptors. Beta 2 receptor stimulation is a very potent mechanism for initiating fat loss. Stimulating the beta-2 receptors found in fat cells activates hormone sensitive lipase, to break up stored fat into free fatty acids which are then used as fuel by the body (1). Once those fatty acids are broken up, Albuterol then has the added effect of elevating your metabolism, which helps you use the free fatty acids that it has broken up. It?s a very potent fat burner, as a result of both being able to break up stored fat and make it available as energy, as well as increasing the rate at which this energy is used.

Interestingly, while Clenbuterol increases both muscle size and strength in animal studies (2), the same thing isn?t necessarily true in humans, and if it is, actual studies proving so are nearly impossible to find. It?s suspected to possibly do this, but there?s really no hard evidence of it. And since it?s not approved by the FDA for use in humans, non-anecdotal data proving that Clen actually builds muscle or increases Performance is scarce. Since it?s approved by the FDA for use in asthmatics, studies on humans and Albuterol, regarding exercise Performance are more plentiful. In multiple studies, it has been suggested strongly that it increases strength as well as endurance in humans (3,4). Clen, on the other hand, has anecdotally been reported to reduce endurance in athletes who use it.

In addition, Albuterol may even help the lipid profile (cholesterol)(5), which is definitely something that steroid using athletes may want to consider, when deciding whether or not to include Albuterol in a cutting cycle. In fact, a small dose of it might be useful on nearly any cycle, because of this characteristic.

The main difference between Albuterol and Clen is that Albuterol has a significantly shorter half life of Albuterol. If Clenbuterol happens to give you insomnia, then Albuterol is a much better alternative, because it?s not going to build up in your system to the same degree that Clen can.

I?m typically much more confident recommending Albuterol to athletes instead of Clen, because stimulant induced anxiety and insomnia seem to be much less likely. Also, due to the shorter half life, there?s probably a much lower level of beta-2 receptor downgrade, but the trade off is more frequent dosing. Two to four milligrams, three to four times a day is usually sufficient for an anabolic as well as fat burning effect.


References:



Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans.
Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E775-82. Epub 2003 Jun 24.
J Appl Physiol. 2001 Nov;91(5):2064-70
Med Sci Sports Exerc. 2000 Jul;32(7):1300-6. Effect of salbutamol on muscle strength and endurance Performance in nonasthmatic men. van Baak MA, Mayer lh - leutenizing hormone - , Kempinski RE, Hartgens F.
Aviat Space Environ Med. 2004 Jun;75(6):505-11 Albuterol helps resistance exercise attenuate unloading-induced knee extensor losses. Caruso JF, Hamill JL, Yamauchi M, Mercado DR, Cook TD, Keller CP, Montgomery AG, Elias J.
Metabolism. 1996 Jun;45(6):712-7 Effects of oral Albuterol on serum lipids and carbohydrate metabolism in healthy men. Maki KC, Skorodin MS, Jessen JH, Laghi F.

 

[Dr JIM]

The difficulty with many of the studies on Bata Agonists is their failure to use a control group which takes into account the effect ANY catecholamine has on perfusion. (That's why these drugs are banned by the drug testing agencies which involve endurance sports in particular)

Catecholamines increase blood flow and thereby increase oxygen availability which may improve performance or endurance by it's very nature.

However, that physiologic effect is entirely different from the protein anabolism whereupon enhanced protein synthesis is a direct consequence of a particular substances anabolic mediation.

Rest assured I've searched previously for any data reflective of this direct anabolic effect but I've come up empty handed each and every time. However if you can locate such an article I'm all ears mate!

Best to ya
jimmy

 

[Jimmyinkedup]

Here is a nice write up compliments of the late Karl Hoffman. I think its most important that albut is primarily a fat loss and ergogenic aid. The fact that a thermogenic isn't catabolic in and of itself is huge. Anyway here is a little info for you:

More evidence for anabolic properties of albuterol

Aviat Space Environ Med. 2004 Jun;75(6):505-11

Albuterol helps resistance exercise attenuate unloading-induced knee extensor losses.

Caruso JF, Hamill JL, Yamauchi M, Mercado DR, Cook TD, Keller CP, Montgomery AG, Elias J.

Exercise Physiology Laboratory, University of Nevada, Reno, NV, USA.

john-caruso@utulsa.edu

INTRODUCTION: While resistance exercise (REX) attenuates knee extensor (KE) mass and strength deficits during short-term unloading, additional treatments concurrently administered with REX are required to reduce the greater losses seen with longer periods of unloading. METHODS: To determine whether Albuterol helps REX attenuate unloading-induced KE losses, two groups of subjects strength trained their left thigh three times per week, and otherwise refrained from ambulatory and weight-bearing activity for 40 d while receiving a capsule dosing treatment (Albuterol, placebo) with no crossover. A third group served as unloaded controls (CTRL). On days 0, 20, and 40, the following data were collected from the nonweight-bearing (left) thigh: cross-sectional area (CSA); integrated electromyography (IEMG); and concentric and eccentric KE strength measures. Thigh CSA was estimated using anthropometric methodology. IEMG was used to provide root mean square (RMS) values from submaximal (100 nm) and maximal isometric contractions. Concentric and eccentric strength were measured from eight-repetition unilateral leg press sets. RESULTS: Repeated-measures mixed-factorial 3 x 3 ANCOVAs with day 0 values as a covariate showed group by time interactions for concentric and eccentric total work (CTW, ETW). Tukey's post hoc test showed REX-Albuterol evoked significant (p < 0.05) day 40 CTW and ETW gains vs. within-group day 0 and within-time REX-placebo and CTRL values. By days 20 and 40, CTRL subjects incurred significant decrements. CONCLUSIONS: Albuterol augmented the effects of REX to increase CTW and ETW. Research identifying possible mechanisms responsible for such changes, as well as the safety of REX-Albuterol administration in other models, is warranted.


Perhaps Albuterol is more aptly classified as an ergogenic aid rather than an anabolic compound. One could go to Pub Med and search under something like "Albuterol strength" but w/o quotation marks. It seems to improve strength and endurance at therapeutic doses according to several studies. The data in humans for clen in this regard are pretty scanty.

Likewise a search under something like "Albuterol fat" shows it promotes lioplysis.

So IMO it is superior to clen for both strength gains and fat loss.

It also seems to improve the cholesterol profile in normal men:

"Significant alterations (P < or = .02) were observed in total cholesterol ([TC] -9.1% +/- 2.5%), low-density lipoprotein cholesterol ([LDL-C] -15.0% +/- 2.9%), and high-density lipoprotein cholesterol ([HDL-C] +10.4% +/- 3.2%) concentrations, as well as the TC/HDL-C (-17.4% +/- 2.6%) and LDL-C/HDL-C (-22.9% +/- 2.4%) ratios." (1)

And I don't know what the one person was drinking, but I've been playing with different concentrations, and a 4 mg/ml solution, which is in the therapeutic range used by a number of studies, is essentially tasteless.

(1) Metabolism. 1996 Jun;45(6):712-7

Effects of oral Albuterol on serum lipids and carbohydrate metabolism in healthy men.

Maki KC, Skorodin MS, Jessen JH, Laghi F.

 

[Dr JIM]

Agreed Jimmy, since similar changes have been observed in hyperperfused tissue in hyperbaric chambers. (I'm quite sure those studies involved our little friends which still has some utility, I suspect)

However there is no demonstrable evidence the net effect (enhanced "strength or endurance") is mediated by anything other than improved blood flow. The latter is highly dependent upon which receptors are activated (alpha or beta) and that is unequivocally dose related. (IME, most BB exceed the optimal dose believing , again, more is better)

An important aspect of the latter, the end point and benefit will be very narrow upon continued beta agonist use, UNLESS combined with AAS.

The observation of a very limited therapeutic index is entirely consistent with the varying degrees of physiologic tolerance which develops quite rapidly to supplemental catecholamines such as cocaine and meth for example. How many of those chronic recreational abusers are anything but "skinny".

Consequently any anabolic windfall someone achieves because of beta agonist use is almost exclusively the result of improved blood flow and relatively small, especially when compared to AAS, IMO.

Nice having your on board again jimink friend

 

[Jimmyinkedup]

Agreed Jimmy, since similar changes have been observed in hyperperfused tissue in hyperbaric chambers. (I'm quite sure those studies involved our little friends which still has some utility, I suspect)

However there is no demonstrable evidence the net effect (enhanced "strength or endurance") is mediated by anything other than improved blood flow. The latter is highly dependent upon which receptors are activated (alpha or beta) and that is unequivocally dose related. (IME, most BB exceed the optimal dose believing , again, more is better)

An important aspect of the latter, the end point and benefit will be very narrow upon continued beta agonist use, UNLESS combined with AAS.

The observation of a very limited therapeutic index is entirely consistent with the varying degrees of physiologic tolerance which develops quite rapidly to supplemental catecholamines such as cocaine and meth for example. How many of those chronic recreational abusers are anything but "skinny".

Consequently any anabolic windfall someone achieves because of beta agonist use is almost exclusively the result of improved blood flow and relatively small, especially when compared to AAS, IMO.

Nice having your on board again jimink friend

Nice to be here Dr Jim and as always nice reading the knowledge you share here!

 

[Dr JIM]

Hey but what's your experience with the beta agonists, mate.

I suspect someone with your personal insight is what SW is looking for really.

Wadya think?

 

[Jimmyinkedup]

I now use albut exclusively not clen. Its much more manageable with less sides and i use it for wht it is..merely an aid and at what is considered moderate dosages. The key is really diet and training..these are just an aid that gives you a slight edge.
For several years i used clen, walking around shaking, changing my shirt a couple times a day and having trouble sleeping only to find that albut at a moderate dose along with ketotifen at night before bed gives me almost just as good results with far fewer unpleasant sides.

 

[skywalk]

I now use albut exclusively not clen. Its much more manageable with less sides and i use it for wht it is..merely an aid and at what is considered moderate dosages. The key is really diet and training..these are just an aid that gives you a slight edge.
For several years i used clen, walking around shaking, changing my shirt a couple times a day and having trouble sleeping only to find that albut at a moderate dose along with ketotifen at night before bed gives me almost just as good results with far fewer unpleasant sides.

thank you for all the valuable replies. I have just placed my order and it should arrive within the month.

my plan is to take albuterol 4mgx3 times per day, and slowly work up to 16-20mg, depending on sides.

im wondering if I should start ketotifen from day 1, or should I wait a week or two before starting it? I read that the dose of keto should be 1-2mg per day...sound about right?

lastly, how long should this mini cycle be? 2weeks like clen or can I take it for up to a month?

if this works, I have a few hundred tabs of clen that im probably gonna throw away.

 

[MythotiK]

Thank you for the info...

 

[Gunrunner]

Well, you sold me on trying it. Our friends at CEM-MESO just started a sale today on these items

 

[zeno]

I gave Albuterol a couple of chances. Made me personally feel like garbage. The benefit over clen is if you feel like shit, you can wait a couple of hours and your back to normal.

 

[PSUGuy]

That was some quality info, thanks guys. I was recently thinking about these two drugs as well.

Edit: I'm thinking about a Anavar + Albuterol cutting cycle

 

[Skull]

Imma bring this thread back to life due to my so far unanswered question. Its actually a question for my fiancé that I have yet to find the answer to on my own so imma turn this one over to my brothas.

How long should she wait after ending a 2 month cycle "that she is currently on btw" to be safely able to begin a new one??????

 

[XKawN]

Imma bring this thread back to life due to my so far unanswered question. Its actually a question for my fiancé that I have yet to find the answer to on my own so imma turn this one over to my brothas.

How long should she wait after ending a 2 month cycle "that she is currently on btw" to be safely able to begin a new one??????

Cycle? Are you referring to an Albuterol cycle?

 

[Skull]

Cycle? Are you referring to an Albuterol cycle?

Yep that's it. Was wondering how long to stay off before using it again? You have any experience with it bro?

 

[XKawN]

Yep that's it. Was wondering how long to stay off before using it again? You have any experience with it bro?

Not women experience, lol, but I dont think, other than dosage/tolerance, it makes a difference. I usually would just take 2 to 3 weeks off to give my receptors a break. I've used it quite a bit in the past. Would only use it maybe a month along side t3 increasing my dose along the way. As far as clenbuterol (for the others in the thread) I've only used helios (injectable clenbuterol and yohimbine) to compare to. As a stimulant I liked the helios better. It was fast in/fast out.

 

[ironwill1951]

I have used both I like albuterol because of less sides, but it should be mentioned that their seems to be a rebound effect if your diet is not on point the fat will return rapidly.

 

[GearGodess]

Yep that's it. Was wondering how long to stay off before using it again? You have any experience with it bro?

Skull, use the typical rule of thumb for women cycling - time off = time on, I would stay off Albuterol for the same amount of time I was on. I typically run Albuterol and T3 for 6 weeks with my cycles and even off... so I take 6 weeks off before going on again. No rebounds, no issues, nothing bad to report when I do it this way.