I have searched the forum and seen others have been getting high resting heart rate from tirz but didn’t see anyone finding a solution. I’m currently using around 3 mg weekly and mg resting heart rate has gone from 60 to 80 is there anything I can do to help apart from stop the Tirzepatide? Is an increase like that a cause for concern with no other health issues? I know lots of people have a rhr of 80 and my fitness watch tells me my heart rate is average to good for my age group but I’m used to being a lot lower so it’s bothering me.
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Anyone found a solution to high heart rate on Tirzepatide?
- Thread starter Hardtimes
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Ghoul
Well-known Member
TLDR: It's not associated with cardiac problems and although it increases with dose, as treatment continues it goes down again, This happens because of GLPs effect on the vagus nerve. It lowers blood pressure and increases heart rate.
Ty. Yes I have noticed a few drops in blood pressure and it’s already pretty low. I don’t want to stop using it as it’s one of the few things I feel is genuinely doing me good but I’ll see how it goes over the next few weeks. I don’t really know what beta blockers do but I read they reduce heart rate but no good for this kind of thing?
thejumpingsheep
New Member
Odd... if anything my experience is lower BP, lower HR, and I feel tired... I usually have to force myself to work out. Something else might be going on?
Thought it was worth an update, I stuck with the tirz to see if my rhr would go down and in the past week it has went from 80 to 71, feels so much better and I get to stay on a low dose of tirz I was on the verge of stopping it if it went above 80 but thankfully all going in the right direction hoping it goes down another 5 or 6 bpm in the next week too.
Type-IIx
Well-known Member
You're fine since the benefit of tirzepatide outweighs the risk of elevated pulse by +20 bpm from 60 to 80 bpm [well within the normal/healthy range]:
View: https://youtube.com/shorts/AJvH0GIu4yk
Thanks I’m down from 80 to 70 in a week now and still reducing so it seems to be really improving and I still get to use tirz. It really is something that makes me feel good so stopping felt wrong and I’m glad I persevered. Speed of fat loss has slowed a bit this week but I’m not going to increase the dose as even at this level I’m happy and feel fitter. Tirz really is a great thing.
No CBB or BB will reduce HR on GLP1.
So no nebivolol or amlodipine or other stuff will work much. Because glp-1 stimulate the vagus nerve and those meds don't do shit to it.
If you stay below 100HR you are still in a healthy range so I would say it's fine and just focus on the nice benefit those glp-1 will give you.
Many ppl report a reduction in HR later on after few months of use so it's probably just waiting and hoping to fix itself with time.
So no nebivolol or amlodipine or other stuff will work much. Because glp-1 stimulate the vagus nerve and those meds don't do shit to it.
If you stay below 100HR you are still in a healthy range so I would say it's fine and just focus on the nice benefit those glp-1 will give you.
Many ppl report a reduction in HR later on after few months of use so it's probably just waiting and hoping to fix itself with time.
Ghoul
Well-known Member
It's no exaggeration to say GLPs are the single most important medical development in our lifetimes, in terms of disease prevention, quality of life, and longevity. A cheap, accurate test that quickly, objectively identifies GLP hormone insufficiency or insensitivity. would snuff out the last bit of strident resistance to these compounds as a "diet pill crutch". Even here on MESO, attitudes have dramatically changed in just 6 months.
If you really want to go down the rabbit hole, the Vagus nerve plays a central role in metabolic homeostasis (the weight "thermostat" I've referred to), transmitting nutrient requirements to the brain, and detects signs of infection, endotoxin being one of the triggers its exquisitely sensitive to, recruiting the brain to induce systemic inflammation.
So here we can see how GLP's impact on the Vagus nerve affects heart rate, reduces appetite, and lowers systemic inflammation.
The vagus nerve and the inflammatory reflex—linking immunity and metabolism - PMC
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism ...
pmc.ncbi.nlm.nih.gov
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yeah I have stopped thinking about it, when I was using GLP1 at my worse I still was below 100HR (hovered around 95-90) so fuck it, I bet if I dropped the HGH I would have probably lost 10bpm at least.It's no exaggeration to say GLPs are the single most important medical development in our lifetimes, in terms of disease prevention, quality of life, and longevity. A cheap, accurate test that quickly, objectively identifies GLP hormone insufficiency or insensitivity. would snuff out the last bit of strident resistance to these compounds as a "diet pill crutch". Even here on MESO, attitudes have dramatically changed in just 6 months.
If you really want to go down the rabbit hole, the Vagus nerve plays a central role in metabolic homeostasis (the weight "thermostat" I've referred to), transmitting nutrient requirements to the brain, and detects signs of infection, endotoxin being one of the triggers its exquisitely sensitive to, recruiting the brain to induce systemic inflammation.
So here we can see how GLP's impact on the Vagus nerve affects heart rate, reduces appetite, and lowers systemic inflammation.
The vagus nerve and the inflammatory reflex—linking immunity and metabolism - PMC
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism ...
Still all the cardiologist I spoke to, told me that if it's below 100 don't bother it's fine, you will be ok nothing to worry about.
but for anyone blasting Beta blocker hoping to run it down, don't bother, it will not change shit, at least it didn't for me.
Ghoul
Well-known Member
Also, like most noticeable side effects of GLPs, it seems to settle down. Perhaps the vagus nerve or the brain down regulates the response to GLP activation.
One major problem with the lack of understanding of GLP, by both patients and a lot of medical personnel, is that with continued use, eventually, staying on the same dose, you feel *nothing*. You're just healthier.
Meanwhile, casual users take that to mean it's stopped working. Some docs think that means it's time to stop using it. While pharma clearly, but quietly calls that reaching the "maintainance dose".
I suspect the drug companies don't want to publicize the fact that to maintain the benefits, like insulin or TRT, you have to keep using the exogenous hormone, essentially, for life. Fewer would be willing to try it if they knew that, despite the fact it's virtually a "fountain of youth" treatment in many respects.
I had the lethargy until I hopped on trt and it went away after a few weeks. Might be due to testosterone dropping from weight loss?
Hardcoreboy
New Member
I have reached the maintenance dose of 15mg and the weight doesn't seem to be coming off anymore. Do I dare to increase the dose even more? What is the maximum dose?
Ghoul
Well-known Member
The way the "maintainance dose" is established is when you reach goal weight and stabilize. While 15mg Tirz is the max pharma trials established as safe, we know there's a built in safety buffer. It's not going to be "15 is safe 16 is toxic".
In addition, from extensive experience with. both, UGL tirz is not as strong as the equivalent dose of pharma. If I had to guess, it's at least a 25% difference in potency, if not a little more.
So although I advocate sticking to the pharma protocol, I wouldn't hesitate to say 20mg, even 25mg of UGL is fine if that's needed for you reach goal weight. Keep in mind if you ever switch to pharma, lower the dose, so you don't overdo it.
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I personally would try more frequent dosing, every 5 days first before titrating up
roofer22
Well-known Member
I can agree with most of what you say except this. I don't believe there's a "thermostat). You just get tolerance and that's that. I've had some big swings on these meds and weight gain never effected the food craving part. I think that's a bit of a stretch.
Ghoul
Well-known Member
GLP isn't an appetite suppressant. It's a naturally produced hormone that's central to the energy homeostasis (weight regulation) system.
Tolerance doesn't develop to insulin, or testosterone, requiring ever increasing doses.
All the evidence shows at a fixed dose, weight drops to a certain level, and stays there, with some minor variation, until the dose is titrated up, then weight drops more, and stays there until it's titrated up again.
Once treatment is stoped, in the overwhelming majority of cases, weight gradually returns.
If tolerance developed, then weight wouldn't stabilize for years at the same dose, but gradually return as tolerance builds. A "maintainance dose" wouldn't be possible, yet it clearly exists.
When people get bariatric surgery, weight loss and improved glucose control aren't because their stomachs are reduced in size, but because food moves into the intestines quickly, stretching them more than usual. Intestinal hypertrophy releases GLP-1, and this increased level of GLP has all the same effects as a shot of the exogenous GLP.
Basically, this is the *hard way* of compensating for a GLP hormone deficit vs injecting it.
The Role of GLP-1 in the Metabolic Success of Bariatric Surgery - PMC
Two of the most popular bariatric procedures, vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), are commonly considered metabolic surgeries because they are thought to affect metabolism in a weight loss–independent manner. In ...
pmc.ncbi.nlm.nih.gov
If someone stays on the same dose of exogenous GLPs, and weight starts to return, that's a sign of immunogenicity, with antibodies developing to neutralize the drug. Immunogenicity didn't rise to a clinically significant level in the pharma trials of Sema and Tirz (it has with other pharma GLPs), but we're not dealing with carefully manufactured pharma products designed to minimize that reaction. It's entirely possible haphazard use of UGL versions are gradually making people immune to Sema and Tirz, reducing or completely eliminating their effectiveness.
thejumpingsheep
New Member
Friendly warning that this doesnt seem to work for some people. I tried it for about a month and it was an abject failure to split the dose up and inject more frequently.
I went from 10mg weekly, to 2mg daily for 30 days and it didnt work even though my dosage went up to 14mg. I had zero reaction to the 2mg daily shot. After that I did 12mg in a single weekly shot and it started working again.
I think I know why it doesnt work. You would need much higher dosage. So when I sat down to run the numbers using daily 2mg I got
effective range of 12.48 - 14.48mg with an average of 13.48mg over 14 days
This sounds good except for one thing... when you do weekly of 14mg, you get this:
effective range of 8.48 - 22.48mg with an average of 15.48mg over 14 days
See the difference? The average isnt far off but look at the spike. Its that spike at day 7 that might be making the difference for me. On that day, you still have most of your dose from the previous week and you inject another dose on day 7 which spikes your dose for a few days post. This gets higher until we reach the total elimination of the 1st dose which takes almost a month. So that spike, keeps getting higher for almost the entire time!
So I have a feeling that its not about the average dosage but rather the spikes and how your body reacts to said spike.
Again all anecdotal but that seems to be the case for me.
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