Aromatase Inhibitors and Joint Pain

[brutus79]

Guys I think I have a problem with my E2 levels cause I just started trt at 150mg EW and I split it 75mg on Monday and Thursday
And I am on my second week and in not getting morning wood so idek if that's a problem since I just started
But
I have some left over Adex and I'm wondering if I should take it and how I should take it like .5mg once a week? Idk
But
Can I please have someone help me on this Like should I even be worried?

The problem is the word "think". Get bloods so you can say "know". A bunch of Internet know it all have no idea what your e2 or issue in general is.

 

[brutus79]

So it appears that all AI's are best avoided. I thought that it was just adex and letro that can cause the bad musculoskeletal side effects, but it appears that Aromasin may be just as bad? Are there any other ways to lower E2 apart from using AI's? Is calcium d-glucarate effective?

Improper dosing (overdosing) of Ai's is best avoided. The use of them is largely user dependant. What estrogen sides does the user suffer? If I had a choice between tits and sexual dysfunction or joint pain I am choosing joint pain. If none of those sides are present in the user they have different choices to make. Bloods are of paramount importance in discerning from what the issue actually is. Having something go "wrong" during a cycle and assuming it is simply estrogen and throwing a powerful medication at the problem without being positive about the diagnosis is irresponsible to say the least. Another option are serm like nolva and ralox... they will block all of the estrogen receptors, but without actually eliminating the aromatase from your system you are playing with fire. Miss taking the nolva for a few days with sky high e2 and you could have d cups. Get bloods.

 

[johnsmith081734]

The problem is the word "think". Get bloods so you can say "know". A bunch of Internet know it all have no idea what your e2 or issue in general is.

Thanks man like I was a bit bloated and I took .5 of Adex 2 days ago and the bloat went down an I was just in a shitty ass mood so I'm not even about to take any Adex untill I get bloodwork done

 

[Michael Scally MD]

Management of Aromatase Inhibitor–Induced Musculoskeletal Symptoms

Aromatase inhibitor–induced musculoskeletal symptoms (AIMSS) were first recognized as a distinct entity in 2001, 5 years after the approval of the first aromatase inhibitor, anastrozole. Musculoskeletal symptoms can severely affect patients’ quality of life and also lead to premature discontinuation of aromatase inhibitor therapy.

Several interventions for managing AIMSS have been investigated in the last decade, with some demonstrating promise. This article provides an evidence-based summary to guide practicing oncologists in regard to the epidemiology, prevention, and treatment of AIMSS.

Gupta A, Henry NL, Loprinzi CL. Management of Aromatase Inhibitor–Induced Musculoskeletal Symptoms. JCO Oncology Practice 2020:OP.20.00113. https://doi.org/10.1200/OP.20.00113