Best ped for anti-aging ..

[malfeasance]

.8ius or roughly 266mcgs is standard starting dose for replacement
Try that and get tested

Really?

Wow.

I mean, I had no idea. I just keep reading it is 2 iu, and I assumed the folks posting that knew what they were talking about.

 

[Benf15harp]

Really?

Wow.

I mean, I had no idea. I just keep reading it is 2 iu, and I assumed the folks posting that knew what they were talking about.

Bro starting dose is 2ius

GENOTROPIN® (somatropin) Dosage and Administration | Pfizer Medical - US

GENOTROPIN® (somatropin) Dosage and Administration 2 DOSAGE AND ADMINISTRATION The weekly dose should be divided into 6 or 7 subcutaneous injections. GENOTROPIN must not be injected intravenously. Therapy with GENOTROPIN should be supervised by a physician who is experienced in the diagnosis...

www.pfizermedicalinformation.com

 

[malfeasance]

Wow, even those maximums are low

.08 mg/kg/wk

a 220 pound male (100kg to make the math easy) is 8 iu a week, barely 1 iu a day.

 

[buck]

I tend to find bro's ideas of healthy replacement/starting dose for most drugs is higher then what science tends to show. I am in my 60;s and my last 2 igf-1 tests have shown i am just below the middle of the range. So i would need little to raise my readings unless my down regulated and then i would need enough to make up for that.

 

[xrayphoton13]

All doctors know how to add years to life.

Few know how to add life to years.

I feel this. I see it everyday working in the hospital. People that are alive but maybe shouldn't be due to quality of life with little to no chance of improvement

 

[clearheaded]

Bro starting dose is 2ius

GENOTROPIN® (somatropin) Dosage and Administration | Pfizer Medical - US

GENOTROPIN® (somatropin) Dosage and Administration 2 DOSAGE AND ADMINISTRATION The weekly dose should be divided into 6 or 7 subcutaneous injections. GENOTROPIN must not be injected intravenously. Therapy with GENOTROPIN should be supervised by a physician who is experienced in the diagnosis...

www.pfizermedicalinformation.com

bro starting dose is 0.6 iu for adults

but MAX dosage is ~3iu per day for adults for 2-4 months, before going off. starting dose per kg is 3x-5x higher in kids per kg for example.

fact of the matter is need blood tests to KNOW as everyone is going to respond differently.

we also have to look at the study to know what they are doing as even TRT dosing regimes really get you ALOT higher than normal if compare 8 pm levels naturally healthy man vs 150-200mg trt dose.

 

[Benf15harp]

bro starting dose is 0.6 iu for adults

but MAX dosage is ~3iu per day for adults for 2-4 months, before going off. starting dose per kg is 3x-5x higher in kids per kg for example.

fact of the matter is need blood tests to KNOW as everyone is going to respond differently.

we also have to look at the study to know what they are doing as even TRT dosing regimes really get you ALOT higher than normal if compare 8 pm levels naturally healthy man vs 150-200mg trt dose.

 

[ToastEater]

Props for one of my favourite posts in this thread. I don't dare add an opinion. Just appreciative for the collective wisdom here while I read, learn, and enjoy my popcorn.

Besides the obvious (weight training, cardio, sleep, and nutritoion), Rapamycin seems to be number one.

Other drugs like Acarbose, SGLT2 like Empagliflozin, Telmisartan, statin/Ezetimibe combo, and cialis seem to be life extending as well.

On the supplement side, the glycine/nac combo, melatonin, astaxanthin, and taurine are the ones that stand out.

collagen & hyaluronic acid for better skin. Also tretinoin face cream. sunscreen to prevent skin aging.

Making sure you aren't deficit in any nutrients (magnesium, vitamin d, b vitamins like b12, folate, etc.)

Also, making sure you aren't deficit in any hormones (testosterone, thyroid, igf, etc.)

 

[ToastEater]

What I DID do was run this entire post through chat. I have an anti-aging / successful-agong model that I'm training. Here's the output:

Your approach integrates cutting-edge research with practical interventions for longevity and health optimization. Here’s an analysis of each component, along with current research:

---

Pharmaceuticals for Longevity​

1. Rapamycin​

• Research: Rapamycin's ability to inhibit mTOR makes it the leading candidate for life extension. It has been shown to:
  • Enhance autophagy.
  • Delay age-related diseases in animal studies.
• Thoughts: While it’s the most promising pharmaceutical for longevity, long-term human studies are lacking. Low-dose regimens could offer benefits with reduced risks.

2. Acarbose​

• Research: Acarbose reduces glucose absorption in the gut, leading to:
  • Improved glucose metabolism.
  • Reduction in postprandial hyperglycemia.
• Thoughts: By mitigating glucose spikes, it may reduce inflammation and oxidative stress, both key drivers of aging.

3. SGLT2 Inhibitors (e.g., Empagliflozin)​

• Research: These drugs lower blood sugar levels and offer:
  • Cardiovascular protection.
  • Improved kidney health.
  • Potential metabolic flexibility benefits.
• Thoughts: They may be particularly valuable for individuals with prediabetes or metabolic syndrome.

4. Telmisartan​

• Research: Telmisartan is an angiotensin receptor blocker (ARB) with additional benefits:
  • Acts as a partial PPAR-gamma agonist, improving metabolic health.
  • Reduces inflammation and oxidative stress.
• Thoughts: Its dual action makes it a strong contender for life extension, especially for cardiovascular health.

5. Statin/Ezetimibe Combo​

• Research: Statins lower LDL cholesterol, while ezetimibe inhibits dietary cholesterol absorption. Together, they:
  • Reduce cardiovascular risk.
  • Address inflammation via lipid modulation.
• Thoughts: For individuals with elevated cholesterol or cardiovascular risk factors, this combo could have longevity benefits.

6. Cialis (Tadalafil)​

• Research: Beyond its use for erectile dysfunction, it:
  • Improves endothelial function.
  • Enhances nitric oxide bioavailability.
  • May reduce inflammation.
• Thoughts: Tadalafil’s cardiovascular benefits and potential for improving microvascular health make it a compelling addition to a longevity regimen.

---

Supplements for Longevity​

1. Glycine/NAC Combo​

• Research: Both support glutathione production, a key antioxidant:
  • Glycine improves mitochondrial function and reduces inflammation.
  • NAC boosts glutathione levels and reduces oxidative stress.
• Thoughts: This combination offers systemic benefits, particularly for combating cellular damage.

2. Melatonin​

• Research: A potent antioxidant and regulator of circadian rhythm:
  • Supports mitochondrial function.
  • Reduces oxidative stress and inflammation.
• Thoughts: Low-dose, nightly melatonin supplementation can improve sleep and provide anti-aging benefits.

3. Astaxanthin​

• Research: A powerful carotenoid antioxidant that:
  • Protects against UV damage.
  • Supports mitochondrial health.
• Thoughts: Its skin and systemic benefits make it a standout supplement.

4. Taurine​

• Research: Emerging studies suggest:
  • Anti-inflammatory and antioxidant properties.
  • Improved cardiovascular and metabolic health.
• Thoughts: Recent animal studies linking taurine to longevity highlight its potential.

---

Skin Health​

1. Collagen & Hyaluronic Acid​

• Research: Both support skin hydration, elasticity, and repair.
• Thoughts: These are excellent additions for maintaining youthful skin.

2. Tretinoin Face Cream​

• Research: A proven treatment for:
  • Reducing fine lines and wrinkles.
  • Promoting collagen synthesis.
• Thoughts: Tretinoin is a gold standard for skin aging reversal.

3. Sunscreen​

• Research: UV radiation is a leading cause of skin aging.
• Thoughts: Daily use is non-negotiable for preventing photodamage.

---

Nutrient Optimization​

1. Key Nutrients​

• Magnesium: Essential for over 300 enzymatic processes, including energy production.
• Vitamin D: Critical for immune function, bone health, and mood.
• B12 and Folate: Necessary for DNA repair and energy metabolism.
• Thoughts: Regular testing and supplementation ensure optimal levels, reducing age-related deficiencies.

---

Hormone Optimization​

1. Testosterone​

• Research: Declines with age, affecting muscle mass, mood, and energy.
• Thoughts: Testosterone replacement therapy (TRT) can support vitality, provided it is closely monitored.

2. Thyroid Hormones​

• Research: Essential for metabolism and energy regulation.
• Thoughts: Addressing hypothyroidism or suboptimal levels can enhance longevity.

3. IGF-1​

• Research: Plays a role in growth and repair but requires balance:
  • Too low: Impaired recovery and vitality.
  • Too high: Increased cancer risk.
• Thoughts: Modulating levels through diet and supplementation (e.g., glycine) is critical.

---

Your Plan is Comprehensive​

Your approach aligns with the latest longevity research. Integrating weight training, cardio, sleep, and nutrition with pharmaceuticals, supplements, and nutrient/hormone optimization provides a multi-faceted strategy for life extension.


Key next steps include:

• Regular testing of blood markers (e.g., lipids, glucose, hormones, inflammation).
• Monitoring emerging research for adjustments.
• Consulting with specialists (e.g., endocrinologists, functional medicine doctors) to fine-tune your regimen.

Besides the obvious (weight training, cardio, sleep, and nutritoion), Rapamycin seems to be number one.

Other drugs like Acarbose, SGLT2 like Empagliflozin, Telmisartan, statin/Ezetimibe combo, and cialis seem to be life extending as well.

On the supplement side, the glycine/nac combo, melatonin, astaxanthin, and taurine are the ones that stand out.

collagen & hyaluronic acid for better skin. Also tretinoin face cream. sunscreen to prevent skin aging.

Making sure you aren't deficit in any nutrients (magnesium, vitamin d, b vitamins like b12, folate, etc.)

Also, making sure you aren't deficit in any hormones (testosterone, thyroid, igf, etc.)

 

[laclark89]

Wow, even those maximums are low

.08 mg/kg/wk

a 220 pound male (100kg to make the math easy) is 8 iu a week, barely 1 iu a day.

I think it is actually 1 iu for an older guy. It declines with age like everything. That’s probably for a guy in his 50’s + just to give them a little boost. I’m pretty sure I asked my old trt/hrt dr about this. I smarted up a bit on this I think lol and now self administer. Saving a shit ton of $

But if I do travel I might need to go back for another script. But then again I don’t mind going off everything for 1-3 weeks. I’ve never taken more than a 3 week vacation, honestly that’s too long for me anyway. And I don’t even really notice going off for 3 weeks.
I’ll never compete so why does it matter to me? Just take a fat shot before I leave.

I’m deep im to my 30’s I feel 2iu is what’s needed for myself. Like u mentioned.

250 test 100 decca and 2 iu is my bace w staying healthy, zero problems but I like to push it 375 test 150 decca and 2-4 iu . But I’ve been laying off the gh lately. Saving for a surgery possibly coming up, because I wana blast and probably add Bpc with it.

Getting old sucks.

Let’s see if someone actually posts numbers igf 1 and age and see how the numbers look ? But everyone’s different trial and error.

 

[ToastEater]

Would VERY MUCH appreciate your insights, brother, on my supps list, as seen below. Not looking for anything comprehensive, I'm mostly curious if you see anything particularly offenskve, based on your experience or research.

I have a family history of high BP & with my dose of Vyvanse I was prescribed irbisartan to keep it in check, as it has creeped up. Just FYI.

Some family history of cancer, but nothing overwhelming. Lots of smokers in my family also...

Some concerns for Alzheimer's & mental decline as my mother is experiencing it in her mid 70's, but feeling good about my plaques & diet. Plus my Dad is still a genius at nearly 80.

Finally, I'm reading this thread to make some decisions about mitigating pain & improving my appearance & success in aging. I have many nagging, long term injuries plus I'd like my face and skin to look much younger - like Mike O'Hearn lol (but not so douchey).

I'm 48, 215, 6'2", and about 12% BF with ab & upper quad veins. 5x per week training regimen with strong cardio health & excellent muscle mass when compared to the general population.

Considering Adding:
1-2iu HGH daily
150mg Deca per week
BPC-157
TB-500

4A
SUPPLEMENTS:
-1L water
-5g Creatine
-5g Collagine
-tsp Matcha tea
-5g Veggie greens
-15ml lemon juice
-15ml apple cider vinegar
-5g Branched chain amino acid
-tsp Curcumin
-tsp Ginseng
-tsp powdered mushroom blend of lion's mane, reishi, turkey tail, cordyceps, & chaga
-1 scoop protein powder

4A
MEDICATIONS (M):
-50mg testosterone M/W/F
-Vyvance 50mg/day
-Liquid Prozac 10mg/day
-Finasteride 5mg/day
-Irbesartan 75mg/day

9A
SUPPLEMENTS:
-Green tea extract (SP)
-Zinc 100mg (S)
-vit c 1,000mg (S)
-B Complex (SP)
-Ubiquinol / CoQ10 100mg (SP)
-NAC 1,200mg (SP)
-Omega 3 1,200mg (S)
-Saw palmetto (S)
-Sunflower Lecithin (SP)
-Micro dose psilocybin 200mg 3 days on 3 days off, 3 weeks on 3 weeks off (SP)

2P
MEDICATIONS (M):
-20mg Vyvanse

7P
SUPPLEMENTS:
-Omega 3 1,200mg (S)
-Mag Glycinate 800mg (S)
-KSM-66 Ashwagandha 800mg (S)
-L-theanine 250mg (SP)
-5-HTP 200mg (SP)
-Berberine 500mg (S)
-Chromium Picolinate 200mcg (SP)
-Vit E 400iu (SP)
-D3 & K2 (S)
-Arganine 1000mg (SP)
-pygeum 200mg (SP)

7P
MEDICATIONS (M):
-DHEA 25mg
-Pregnenelone 25mg
-Low Dose Naltrexone 25mg

(M) is for prescribed medication by my Family Dr, Psychiatrist, &/or my Aging Dr who is also an Endocrinologist.

(S) is for supplements prescribed by my Aging Dr Endocrinologist.

(SP) is for Self Prescribed.

(M) Testosterone:
Energy boost, optimism, better sleep, increase muscle, reduce brain fog, better memory, fat loss, reduce depression, reduce anxiety, better insulin sensitivity

(M) DHEA:
It's on the testosterone pathway, and supports the benefits of testosterone.

(M) Pregnenolone:
It's a precursor to DHEA, so on the same pathway as testosterone with all the same benefits.

(M) Anastrozole & EstroDim:
Reduces estrogen, eliminates puffiness, minimizes emotional responses.

(M) Low Dose Naltrexone:
Reduces sugar cravings and reduces alcohol cravings & is an incredible immune booster.

(M) Vyvance:
Eliminates most ADHD symptoms. Boosts energy. Hunger management. Focus. Reduces anxiety.

(M) Prozac:
Prescribed for RSD (Rejection Sensitive Dysphoria).

(M) Finasteride:
Prescribed to stop hairloss

(M) Irbesartan:
Regulates blood pressure.

(S) Omega 3:
Heart health, reduces brain fog, longevity, reduces ADHD symptoms.

(S) Zinc:
Improves immunity & health response.

(S) Mag Glycinate:
Bone health, reduces blood sugar.

(S) D3 & K2:
Immune system function, bone growth and density. Health of many tissues in the body, including prostate, & colon.
Cardiovascular health. Blood sugar balance. Healthy mood, & mental clarity.

(S) Saw Palmetto:
Protect hair, natural testosterone production, decrease inflammation, & prostate protection.

(S) Berberine:
Blood sugar control just as good as Metformin

(SP) Psilocybin:
Mental health, anxiety, clarity, visioning, flow state enhancement. Macro dose 2X per year for flow & state "reset".

Yea, I used to take way more supplements that I no longer take. Btw, NMN has very unimpressive human data too, so that one is a bust like resveratrol. At this point, I take an equal number of drugs and supplements for health purposes. Supplements I now use are taurine, astaxanthin, collagen & hyaluronic acid powder, NAC, creatine, PQQ, Ubiquinol, betaine TMG, white willow bark, DHEA, pregnenolone, and melatonin.

 

[laclark89]

Would VERY MUCH appreciate your insights, brother, on my supps list, as seen below. Not looking for anything comprehensive, I'm mostly curious if you see anything particularly offenskve, based on your experience or research.

I have a family history of high BP & with my dose of Vyvanse I was prescribed irbisartan to keep it in check, as it has creeped up. Just FYI.

Some family history of cancer, but nothing overwhelming. Lots of smokers in my family also...

Some concerns for Alzheimer's & mental decline as my mother is experiencing it in her mid 70's, but feeling good about my plaques & diet. Plus my Dad is still a genius at nearly 80.

Finally, I'm reading this thread to make some decisions about mitigating pain & improving my appearance & success in aging. I have many nagging, long term injuries plus I'd like my face and skin to look much younger - like Mike O'Hearn lol (but not so douchey).

I'm 48, 215, 6'2", and about 12% BF with ab & upper quad veins. 5x per week training regimen with strong cardio health & excellent muscle mass when compared to the general population.

Considering Adding:
1-2iu HGH daily
150mg Deca per week
BPC-157
TB-500

4A
SUPPLEMENTS:
-1L water
-5g Creatine
-5g Collagine
-tsp Matcha tea
-5g Veggie greens
-15ml lemon juice
-15ml apple cider vinegar
-5g Branched chain amino acid
-tsp Curcumin
-tsp Ginseng
-tsp powdered mushroom blend of lion's mane, reishi, turkey tail, cordyceps, & chaga
-1 scoop protein powder

4A
MEDICATIONS (M):
-50mg testosterone M/W/F
-Vyvance 50mg/day
-Liquid Prozac 10mg/day
-Finasteride 5mg/day
-Irbesartan 75mg/day

9A
SUPPLEMENTS:
-Green tea extract (SP)
-Zinc 100mg (S)
-vit c 1,000mg (S)
-B Complex (SP)
-Ubiquinol / CoQ10 100mg (SP)
-NAC 1,200mg (SP)
-Omega 3 1,200mg (S)
-Saw palmetto (S)
-Sunflower Lecithin (SP)
-Micro dose psilocybin 200mg 3 days on 3 days off, 3 weeks on 3 weeks off (SP)

2P
MEDICATIONS (M):
-20mg Vyvanse

7P
SUPPLEMENTS:
-Omega 3 1,200mg (S)
-Mag Glycinate 800mg (S)
-KSM-66 Ashwagandha 800mg (S)
-L-theanine 250mg (SP)
-5-HTP 200mg (SP)
-Berberine 500mg (S)
-Chromium Picolinate 200mcg (SP)
-Vit E 400iu (SP)
-D3 & K2 (S)
-Arganine 1000mg (SP)
-pygeum 200mg (SP)

7P
MEDICATIONS (M):
-DHEA 25mg
-Pregnenelone 25mg
-Low Dose Naltrexone 25mg

(M) is for prescribed medication by my Family Dr, Psychiatrist, &/or my Aging Dr who is also an Endocrinologist.

(S) is for supplements prescribed by my Aging Dr Endocrinologist.

(SP) is for Self Prescribed.

(M) Testosterone:
Energy boost, optimism, better sleep, increase muscle, reduce brain fog, better memory, fat loss, reduce depression, reduce anxiety, better insulin sensitivity

(M) DHEA:
It's on the testosterone pathway, and supports the benefits of testosterone.

(M) Pregnenolone:
It's a precursor to DHEA, so on the same pathway as testosterone with all the same benefits.

(M) Anastrozole & EstroDim:
Reduces estrogen, eliminates puffiness, minimizes emotional responses.

(M) Low Dose Naltrexone:
Reduces sugar cravings and reduces alcohol cravings & is an incredible immune booster.

(M) Vyvance:
Eliminates most ADHD symptoms. Boosts energy. Hunger management. Focus. Reduces anxiety.

(M) Prozac:
Prescribed for RSD (Rejection Sensitive Dysphoria).

(M) Finasteride:
Prescribed to stop hairloss

(M) Irbesartan:
Regulates blood pressure.

(S) Omega 3:
Heart health, reduces brain fog, longevity, reduces ADHD symptoms.

(S) Zinc:
Improves immunity & health response.

(S) Mag Glycinate:
Bone health, reduces blood sugar.

(S) D3 & K2:
Immune system function, bone growth and density. Health of many tissues in the body, including prostate, & colon.
Cardiovascular health. Blood sugar balance. Healthy mood, & mental clarity.

(S) Saw Palmetto:
Protect hair, natural testosterone production, decrease inflammation, & prostate protection.

(S) Berberine:
Blood sugar control just as good as Metformin

(SP) Psilocybin:
Mental health, anxiety, clarity, visioning, flow state enhancement. Macro dose 2X per year for flow & state "reset".

Mike o hear is definitely juiced and on a healthy dose of gh. Plus he’s definitely had cosmetic surgeries and or Botox. Anyone can see that.

I don’t know about all that other crap u posted but ur old bones need vitamin d , calcium and glucosamine w msm imo.

I’d skip the bpc and tb enless injuried.
But the gh decca look at w what ever ur test dose is . I Dident see posted. Mabe even 100 decca.

 

[ToastEater]

I'm grateful you know what that article is saying. So, what is that article saying?

...FWIW I've got 8 years of university education & a legitimate MBA (not from an MBA Mill lol). Still can't understand this shit despite my first wife being a Tenured Professor in Kinesiology studying Anti-Aging lol

It still has notable impact on your gut microbiome, including bacterial species and total load.

"Rapamycin is a natural macrolide compound isolated from bacteria and a pharmacological inhibitor of TOR signaling. It can reduce the rate of aging and effectively improve age-related diseases.Citation110 Rapamycin treatment has reportedly altered the number and structure of gut microbiota in flies and mice. The addition of rapamycin to food can significantly reduce the bacterial load of flies (40 days) and delay microbial expansion in the aging gut.Citation93 It also reduces the level of Alphaproteobacteria, which is a group that has been previously recognized to be related to a decline in health and mortality in the elderly.Citation94 In middle-aged mice, transient rapamycin treatment is also associated with microbial remodeling, including a dramatically increased prevalence of segmented filamentous bacteria in the small intestine.Citation95 However, only a few studies have investigated the interaction between rapamycin and gut microbiota. Therefore, whether the change in gut microbiota plays a causal role in the beneficial effect of rapamycin treatment remains to be answered."

Don't get me wrong, it's exciting and super.promising, I'm just going to opt for the compound with zero evidence of gut microbiome impact.

Once we know more with Rapamycin, maybe. But for now, I spend way too much on specific bacterial colonies to turn into yogurts to risk undoing that work, lol.

https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1994835#:~:text=Rapamycin%20treatment%20has%20reportedly%20altered,expansion%20in%20the%20aging%20gut.

 

[laclark89]

Have asleep it’s 4 am .

It sounds like way too much , like I watch to much vigorous Steve, like u stole a bunch of his crap.

 

[Benf15harp]

Would VERY MUCH appreciate your insights, brother, on my supps list, as seen below. Not looking for anything comprehensive, I'm mostly curious if you see anything particularly offenskve, based on your experience or research.

I have a family history of high BP & with my dose of Vyvanse I was prescribed irbisartan to keep it in check, as it has creeped up. Just FYI.

Some family history of cancer, but nothing overwhelming. Lots of smokers in my family also...

Some concerns for Alzheimer's & mental decline as my mother is experiencing it in her mid 70's, but feeling good about my plaques & diet. Plus my Dad is still a genius at nearly 80.

Finally, I'm reading this thread to make some decisions about mitigating pain & improving my appearance & success in aging. I have many nagging, long term injuries plus I'd like my face and skin to look much younger - like Mike O'Hearn lol (but not so douchey).

I'm 48, 215, 6'2", and about 12% BF with ab & upper quad veins. 5x per week training regimen with strong cardio health & excellent muscle mass when compared to the general population.

Considering Adding:
1-2iu HGH daily
150mg Deca per week
BPC-157
TB-500

4A
SUPPLEMENTS:
-1L water
-5g Creatine
-5g Collagine
-tsp Matcha tea
-5g Veggie greens
-15ml lemon juice
-15ml apple cider vinegar
-5g Branched chain amino acid
-tsp Curcumin
-tsp Ginseng
-tsp powdered mushroom blend of lion's mane, reishi, turkey tail, cordyceps, & chaga
-1 scoop protein powder

4A
MEDICATIONS (M):
-50mg testosterone M/W/F
-Vyvance 50mg/day
-Liquid Prozac 10mg/day
-Finasteride 5mg/day
-Irbesartan 75mg/day

9A
SUPPLEMENTS:
-Green tea extract (SP)
-Zinc 100mg (S)
-vit c 1,000mg (S)
-B Complex (SP)
-Ubiquinol / CoQ10 100mg (SP)
-NAC 1,200mg (SP)
-Omega 3 1,200mg (S)
-Saw palmetto (S)
-Sunflower Lecithin (SP)
-Micro dose psilocybin 200mg 3 days on 3 days off, 3 weeks on 3 weeks off (SP)

2P
MEDICATIONS (M):
-20mg Vyvanse

7P
SUPPLEMENTS:
-Omega 3 1,200mg (S)
-Mag Glycinate 800mg (S)
-KSM-66 Ashwagandha 800mg (S)
-L-theanine 250mg (SP)
-5-HTP 200mg (SP)
-Berberine 500mg (S)
-Chromium Picolinate 200mcg (SP)
-Vit E 400iu (SP)
-D3 & K2 (S)
-Arganine 1000mg (SP)
-pygeum 200mg (SP)

7P
MEDICATIONS (M):
-DHEA 25mg
-Pregnenelone 25mg
-Low Dose Naltrexone 25mg

(M) is for prescribed medication by my Family Dr, Psychiatrist, &/or my Aging Dr who is also an Endocrinologist.

(S) is for supplements prescribed by my Aging Dr Endocrinologist.

(SP) is for Self Prescribed.

(M) Testosterone:
Energy boost, optimism, better sleep, increase muscle, reduce brain fog, better memory, fat loss, reduce depression, reduce anxiety, better insulin sensitivity

(M) DHEA:
It's on the testosterone pathway, and supports the benefits of testosterone.

(M) Pregnenolone:
It's a precursor to DHEA, so on the same pathway as testosterone with all the same benefits.

(M) Anastrozole & EstroDim:
Reduces estrogen, eliminates puffiness, minimizes emotional responses.

(M) Low Dose Naltrexone:
Reduces sugar cravings and reduces alcohol cravings & is an incredible immune booster.

(M) Vyvance:
Eliminates most ADHD symptoms. Boosts energy. Hunger management. Focus. Reduces anxiety.

(M) Prozac:
Prescribed for RSD (Rejection Sensitive Dysphoria).

(M) Finasteride:
Prescribed to stop hairloss

(M) Irbesartan:
Regulates blood pressure.

(S) Omega 3:
Heart health, reduces brain fog, longevity, reduces ADHD symptoms.

(S) Zinc:
Improves immunity & health response.

(S) Mag Glycinate:
Bone health, reduces blood sugar.

(S) D3 & K2:
Immune system function, bone growth and density. Health of many tissues in the body, including prostate, & colon.
Cardiovascular health. Blood sugar balance. Healthy mood, & mental clarity.

(S) Saw Palmetto:
Protect hair, natural testosterone production, decrease inflammation, & prostate protection.

(S) Berberine:
Blood sugar control just as good as Metformin

(SP) Psilocybin:
Mental health, anxiety, clarity, visioning, flow state enhancement. Macro dose 2X per year for flow & state "reset".

 

[Liter O' Test]

Mike o hear is definitely juiced and on a healthy dose of gh. Plus he’s definitely had cosmetic surgeries and or Botox. Anyone can see that.

I don’t know about all that other crap u posted but ur old bones need vitamin d , calcium and glucosamine w msm imo.

I’d skip the bpc and tb enless injuried.
But the gh decca look at w what ever ur test dose is . I Dident see posted. Mabe even 100 decca.

mike looks the way he does because he never abused HGH and does woman levels of skincare. also genetics.

 

[NotHuman]

What I DID do was run this entire post through chat. I have an anti-aging / successful-agong model that I'm training. Here's the output:

Your approach integrates cutting-edge research with practical interventions for longevity and health optimization. Here’s an analysis of each component, along with current research:

---

Pharmaceuticals for Longevity​

1. Rapamycin​

• Research: Rapamycin's ability to inhibit mTOR makes it the leading candidate for life extension. It has been shown to:
  • Enhance autophagy.
  • Delay age-related diseases in animal studies.
• Thoughts: While it’s the most promising pharmaceutical for longevity, long-term human studies are lacking. Low-dose regimens could offer benefits with reduced risks.

2. Acarbose​

• Research: Acarbose reduces glucose absorption in the gut, leading to:
  • Improved glucose metabolism.
  • Reduction in postprandial hyperglycemia.
• Thoughts: By mitigating glucose spikes, it may reduce inflammation and oxidative stress, both key drivers of aging.

3. SGLT2 Inhibitors (e.g., Empagliflozin)​

• Research: These drugs lower blood sugar levels and offer:
  • Cardiovascular protection.
  • Improved kidney health.
  • Potential metabolic flexibility benefits.
• Thoughts: They may be particularly valuable for individuals with prediabetes or metabolic syndrome.

4. Telmisartan​

• Research: Telmisartan is an angiotensin receptor blocker (ARB) with additional benefits:
  • Acts as a partial PPAR-gamma agonist, improving metabolic health.
  • Reduces inflammation and oxidative stress.
• Thoughts: Its dual action makes it a strong contender for life extension, especially for cardiovascular health.

5. Statin/Ezetimibe Combo​

• Research: Statins lower LDL cholesterol, while ezetimibe inhibits dietary cholesterol absorption. Together, they:
  • Reduce cardiovascular risk.
  • Address inflammation via lipid modulation.
• Thoughts: For individuals with elevated cholesterol or cardiovascular risk factors, this combo could have longevity benefits.

6. Cialis (Tadalafil)​

• Research: Beyond its use for erectile dysfunction, it:
  • Improves endothelial function.
  • Enhances nitric oxide bioavailability.
  • May reduce inflammation.
• Thoughts: Tadalafil’s cardiovascular benefits and potential for improving microvascular health make it a compelling addition to a longevity regimen.

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Supplements for Longevity​

1. Glycine/NAC Combo​

• Research: Both support glutathione production, a key antioxidant:
  • Glycine improves mitochondrial function and reduces inflammation.
  • NAC boosts glutathione levels and reduces oxidative stress.
• Thoughts: This combination offers systemic benefits, particularly for combating cellular damage.

2. Melatonin​

• Research: A potent antioxidant and regulator of circadian rhythm:
  • Supports mitochondrial function.
  • Reduces oxidative stress and inflammation.
• Thoughts: Low-dose, nightly melatonin supplementation can improve sleep and provide anti-aging benefits.

3. Astaxanthin​

• Research: A powerful carotenoid antioxidant that:
  • Protects against UV damage.
  • Supports mitochondrial health.
• Thoughts: Its skin and systemic benefits make it a standout supplement.

4. Taurine​

• Research: Emerging studies suggest:
  • Anti-inflammatory and antioxidant properties.
  • Improved cardiovascular and metabolic health.
• Thoughts: Recent animal studies linking taurine to longevity highlight its potential.

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Skin Health​

1. Collagen & Hyaluronic Acid​

• Research: Both support skin hydration, elasticity, and repair.
• Thoughts: These are excellent additions for maintaining youthful skin.

2. Tretinoin Face Cream​

• Research: A proven treatment for:
  • Reducing fine lines and wrinkles.
  • Promoting collagen synthesis.
• Thoughts: Tretinoin is a gold standard for skin aging reversal.

3. Sunscreen​

• Research: UV radiation is a leading cause of skin aging.
• Thoughts: Daily use is non-negotiable for preventing photodamage.

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Nutrient Optimization​

1. Key Nutrients​

• Magnesium: Essential for over 300 enzymatic processes, including energy production.
• Vitamin D: Critical for immune function, bone health, and mood.
• B12 and Folate: Necessary for DNA repair and energy metabolism.
• Thoughts: Regular testing and supplementation ensure optimal levels, reducing age-related deficiencies.

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Hormone Optimization​

1. Testosterone​

• Research: Declines with age, affecting muscle mass, mood, and energy.
• Thoughts: Testosterone replacement therapy (TRT) can support vitality, provided it is closely monitored.

2. Thyroid Hormones​

• Research: Essential for metabolism and energy regulation.
• Thoughts: Addressing hypothyroidism or suboptimal levels can enhance longevity.

3. IGF-1​

• Research: Plays a role in growth and repair but requires balance:
  • Too low: Impaired recovery and vitality.
  • Too high: Increased cancer risk.
• Thoughts: Modulating levels through diet and supplementation (e.g., glycine) is critical.

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Your Plan is Comprehensive​

Your approach aligns with the latest longevity research. Integrating weight training, cardio, sleep, and nutrition with pharmaceuticals, supplements, and nutrient/hormone optimization provides a multi-faceted strategy for life extension.


Key next steps include:

• Regular testing of blood markers (e.g., lipids, glucose, hormones, inflammation).
• Monitoring emerging research for adjustments.
• Consulting with specialists (e.g., endocrinologists, functional medicine doctors) to fine-tune your regimen.

This is awesome technology. Way more comprehensive than I could ever be. I appreciate the kind words too.