malfeasance
Member
Not aware of any issues combining an angiotensin II receptor blocker, a beta blocker, and a dihydropyridine calcium channel blocker?
MESO-Rx
Anabolic Steroids
Blood Pressure
- Thread starter gilmarpersonal
- Start date
Ghoul
Member
You've probobly seen me say this before, but it's now widely accepted that minimum doses of multiple BP meds with different mechanisms of action are more effective with fewer sides than higher doses of any single class. In this case 1+1=4 (or in this case 2+1=6).
ARB/CCB is increasingly becoming the "gold standard" for dual class, with beta blockers and diuretics used when a 3rd or 4th is needed, so a CCB would be ideal if this one works for you as it does for so many that have problems on Amlodipine.
You really want to be as close to 120/70 or slightly below as possible to achieve with meds you can tolerate.
Remember if you feel a little lightheaded initially that almost always resolves within a a couple of weeks to a month, so try to stick with it if your numbers look better.
Ghoul
Member
No that's a common combo, though beta blocker is often tried before diuretic, since it's better tolerated by most, that's not an issue for you since you already know it works, and you've had edema issues. By the way, the diuretic works synergistically with Cildipidine to lower its already very low likelihood of edema to practically zero.
BamaCrazy
Member
Amlodipine gave me edema also. Oddly enough only in my hands while I was sleeping. But it as bad. So I switched to Cilnidipine and I have had no issues. I take 20mg Telmisartan and 10mg Cilnidipine at night, then 10mg Nebivolol in the morning. So an ARB, CCB and a BB daily. Works great for me.
PCT 24 doesn't ship to Europe, unfortunately.
Do you know where I can find it with shipping to the EU at an affordable price?
However, I’m going to try lercanidipine—it seems to be somewhere between amlodipine and cilnidipine in terms of side effects.
I'll be combining it with telmisartan + HCTZ and bisoprolol, all in micro-doses
Do you know where I can find it with shipping to the EU at an affordable price?
However, I’m going to try lercanidipine—it seems to be somewhere between amlodipine and cilnidipine in terms of side effects.
I'll be combining it with telmisartan + HCTZ and bisoprolol, all in micro-doses
Ghoul
Member
Which country?
Western Europe
Ghoul
Member
Come on man. Naming an entire country isn't a threat to your opsec. I need the specific. DM me if you're paranoid
What's the point in knowing anyway? They don't deliver.
BamaCrazy
Member
Because there are many sources and each have different shipping options/restrictions
Ghoul
Member
Because my source is asking me which country in the EU, since they have different policies depending on the country.
That's ok, you're making me work too hard for this.
malfeasance
Member
LOL
Don't answer if you don't want to answer, but it is difficult to be extremely helpful without knowing the country.
Because you were asking about sources that can deliver.
Don't answer if you don't want to answer, but it is difficult to be extremely helpful without knowing the country.
malfeasance
Member
malfeasance
Member
I am very curious how much of a reduction actually occurs when adding a third component, like, in this case, Cildipidine.
malfeasance
Member
Also, there does not appear to be a robust library of research on this drug.
BamaCrazy
Member
Ultra-low-dose quadruple combination blood pressure–lowering therapy in patients with hypertension: The QUARTET randomized controlled trial protocol - PMC
High blood pressure is the leading cause of preventable morbidity and mortality globally. Many patients remain on single-drug treatment with poor control, although guidelines recognize that most require combination therapy for blood pressure ...
pmc.ncbi.nlm.nih.gov
Ghoul posted on another thread a Quad study of 4 classes of BP drugs used at low doses. Here is a similar one (or the same) that concludes adding a 2nd low dose drug is 5 times more effective than doubling the dose of a single drug. And another trial concluded adding a 3rd showed a reduction of 17.4/9.4-mm Hg.
“There is strong evidence that the BP-lowering effects of different classes of drugs are independent and fully additive.15 , 18 The effects of adding a second BP-lowering agent are closely concordant with those predicted by independent effects, occur across all pairs of medication classes, and are about 5 times more effective than doubling the dose of the first agent.18 The additive effects across 3 classes of low-dose drugs were also demonstrated in a placebo-controlled, crossover trial of 3 half-dose BP drugs in 86 participants aged >50 years without a history of cardiovascular disease.19 Overall, a 17.4/9.4–mm Hg BP reduction was observed compared to the anticipated 17.9/9.5–mm Hg decline expected from the cumulative effects of the 3 separate agents.
This study found that 70% of participants in the triple-pill group achieved their target BP versus 55% in the usual-care group“
Netherlands possible looking for it to
But order from.india is 50% seized
Uncle Bub
New Member
I'm having a hard time getting my BP down. I've been taking 80mg Telmi for a couple weeks now and it's not going down. Wanna say my BP monitor been avg close to 145/79.
Before I got into AAS it was fine (120/70) and I was a lot heavier then than I am now. I got some amlodipine coming to go with the Telmisartan. Anything else I should try?
Before I got into AAS it was fine (120/70) and I was a lot heavier then than I am now. I got some amlodipine coming to go with the Telmisartan. Anything else I should try?
Ghoul
Member
Is this pharma or ugl telm?
Have you seen zero noticeable drop in BP, or a little of you know?
