Caffeine + Albuterol combo burns fat without diet changes

[Arnold Strong]

Abstract
OBJECTIVE:
Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.

METHODS:
In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.

RESULTS:
Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.

CONCLUSIONS:
In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4-8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.

http://www.ncbi.nlm.nih.gov/pubmed/26239482

 

[TyroneMoreGains]

If only I was a rat

 

[Arnold Strong]

If only I was a rat

They did tests in humans too. The graph shown illustrates the fact they found significant increases in energy expenditure in 18-50 year-old, healthy, normal-weight humans with very modest doses of caffeine and albuterol.

 

[Sworder]

13% more energy because it is making your heart pump blood like you are on Meth.

 

[SJB78]

I know its a little off topic but I was wondering if pseudoephedrine has the same effect as ephedrine when combined as part of an ECA stack? The reason I ask is because in my country and state I can't get ephedrine over the counter but I can with pseudo...

 

[Sworder]

I know its a little off topic but I was wondering if pseudoephedrine has the same effect as ephedrine when combined as part of an ECA stack? The reason I ask is because in my country and state I can't get ephedrine over the counter but I can with pseudo...

Get pseudoephedrine and make some meth with it. Shake 'n bake.

http://www.panthraxnation.host.sk/shakenbake.html

I use pseudoephedrine from the pharmacy, keep in mind though the way it burns more is by making your heart work harder. There are better ways to burn calories than dumping the load on your heart.

 

[SJB78]

Get pseudoephedrine and make some meth with it. Shake 'n bake.

http://www.panthraxnation.host.sk/shakenbake.html

I use pseudoephedrine from the pharmacy, keep in mind though the way it burns more is by making your heart work harder. There are better ways to burn calories than dumping the load on your heart.

Shake and bake!! I know that shit would shed the kilos real quick.

 

[Sworder]

Shake and bake!! I know that shit would shed the kilos real quick.

Lol yeah but seriously Clen imo is too rough on the heart. Ephedra was banned because fat ppl with clogged blood vessels were running in 110 degree weather. Ephedra (ECA) stack much better imo!

Be careful how you use these CNS stimulants..

 

[MrRippedZilla]

The effect on humans was acute...therefore the reported positive results mean very little in reality. Is that increase in energy expenditure maintained or does the body adapt and reduce the effect?
I'd go with the second option.

The main benefit of ephedrine (and the ec stack) was that it continued to display a thermogenic benefit over the long term (some studies showing that the effect got stronger with time).
This is due to weaker binding affinity for beta receptors, which means less downregulation since EC mainly works by increasing the body's own production of adrenaline/noradrenaline.

Clen is a good example of something that only works short term (unless you have keto on hand, but even then time is limited).
Clen binds very specifically, and strongly, to beta 2 receptors causing rapid downregulation = losing its effect.

Albuterol has a shorter half life than Clen so in theory the beta receptors are getting a break.
However, this table clearly shows that despite albuterol being weaker than clen, it has a STRONGER binding affinity to beta 2 receptors - making the shorter half life advantage close to irrelevant:

http://i.imgur.com/tsduB31.jpg

For me, its still EC > Clen > Albuterol

 

[Sworder]

The effect on humans was acute...therefore the reported positive results mean very little in reality. Is that increase in energy expenditure maintained or does the body adapt and reduce the effect?
I'd go with the second option.

The main benefit of ephedrine (and the ec stack) was that it continued to display a thermogenic benefit over the long term (some studies showing that the effect got stronger with time).
This is due to weaker binding affinity for beta receptors, which means less downregulation since EC mainly works by increasing the body's own production of adrenaline/noradrenaline.

Clen is a good example of something that only works short term (unless you have keto on hand, but even then time is limited).
Clen binds very specifically, and strongly, to beta 2 receptors causing rapid downregulation = losing its effect.

Albuterol has a shorter half life than Clen so in theory the beta receptors are getting a break.
However, this table clearly shows that despite albuterol being weaker than clen, it has a STRONGER binding affinity to beta 2 receptors - making the shorter half life advantage close to irrelevant:

http://i.imgur.com/tsduB31.jpg

For me, its still EC > Clen > Albuterol

The most convenient is diphenhydramine instead of Keto, as it is found easily at the store as a Sleep aid and in Nyquil..

ECA > all tweeker drugs.

Taking a lot of Meth will get you a good THERMOGENIC effect too, the half-life kinda sucks though.

https://www.sciencedirect.com/science/article/pii/S0306452215002559
METH and NA microinjection evoked dose-related increases in heart rate, interscapular brown adipose tissue temperature and expired CO2, a pattern of response characteristic of non-shivering thermogenesis. NA and 5-HT microinjection elicited pressor and depressor responses, respectively, with matching baroreflex adjustments in sympathetic nerve activity while METH and DA evoked no change in vasomotor outflow. Low doses of METH and DA may evoke respiratory depression. These data suggest that METH’s actions in the ventral mPFC, likely via adrenergic receptors, evoke non-shivering thermogenesis which may contribute to the increased body temperature and tachycardia seen in those that abuse METH.

 

[Sworder]

Clenbuterol-Induced Tardive Dyskinesia
http://journals.lww.com/clinicalneu...clenbuterol_induced_tardive_dyskinesia.6.aspx


Obviously Tardive Dyskinesia isn't something relevant for the BB community that use it as a fatburner. My point is:

LESS DRUGS IS BETTER STOP FUCKING WITH TOO MUCH SHIT AND GET OFF YOUR ASS AND RUN

 

[Janoy crevesa]

I've always felt hotter with caffeine and clen/albuterol than it just alone.

 

[Sworder]

I've always felt hotter with caffeine and clen/albuterol than it just alone.

I get super hot after drinking coffee, especially my mouth.

 

[TyroneMoreGains]

I get super hot after drinking coffee, especially my mouth.

Yes.
Talk about that pretty mouth

 

[Sworder]

Yes.
Talk about that pretty mouth

I get a brown layer on my tongue from coffee and chew, I save the "broth" from the tongue scraper though for cooking. Makes the food taste "earthy"

 

[Mike Oxbig]

Stimulants generally cause retrograde-overeating once you cease use. It's simply the body's natural reaction to responding to a chronic state of catecholamine production.

Granted, bodybuilders in general have more willpower to resist the temptation than your typical overweight soccer mom that got scripted Phentermine because she was too lazy/unable to lose weight the natural way, but the point still remains. Cardio should always be number one, especially for those using that are using cell tech and therefor further predispositioned to cardiac issues.

 

[Sworder]

Stimulants generally cause retrograde-overeating once you cease use. It's simply the body's natural reaction to responding to a chronic state of catecholamine production.

Granted, bodybuilders in general have more willpower to resist the temptation than your typical overweight soccer mom that got scripted Phentermine because she was too lazy/unable to lose weight the natural way, but the point still remains. Cardio should always be number one, especially for those using that are using cell tech and therefor further predispositioned to cardiac issues.

Bodybuilders by definition is anybody that exercises to increase performance or strength. So that overweight soccer mom by definition is equally body building if she is "walking the stairs" once a week. This goes to compare to the first time cyclers that start with a "cut cycle" because they spent the last 10 years overeating.

I think in general there is very limited drugs that increase lipolysis in a way that makes it "worth it."
And Cardio and diet should be number 1. Diet before cardio though.

Eat to supply your body with nutrients, not to please your mouth/stomach.

 

[Ozzy619]

I only workout to eat so idgaf

 

[Sworder]

I only workout to eat so idgaf

I only eat to grow my penis so IDGAF either. Nice avi Gonna wank now.

 

[MrRippedZilla]

Stimulants generally cause retrograde-overeating once you cease use. It's simply the body's natural reaction to responding to a chronic state of catecholamine production.

Granted, bodybuilders in general have more willpower to resist the temptation than your typical overweight soccer mom that got scripted Phentermine because she was too lazy/unable to lose weight the natural way, but the point still remains. Cardio should always be number one, especially for those using that are using cell tech and therefor further predispositioned to cardiac issues.

Dieting itself causes overeating - its the body's natural reaction to chronic lack of food

Excessive cardio can cause negative metabolic adaptations (10-15% decrease), which means you need to eat less than expected to maintain after dieting - making maintenance more difficult.

Diet + cardio has been the traditional recommendation for decades - now go look at the obesity statistics, specifically those on people who have dieted and FAILED to maintain the results for the medium-long term.
Spoiler alert: the statistics indicate that diet + cardio isn't resulting in any sort of weight loss maintenance whatsoever.