Caffeine + Albuterol combo burns fat without diet changes

[Arnold Strong]

Abstract
OBJECTIVE:
Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.

METHODS:
In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.

RESULTS:
Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.

CONCLUSIONS:
In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4-8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.

http://www.ncbi.nlm.nih.gov/pubmed/26239482

 

[Docd187123]

Lmao okay sure. You might want to look into that.

Already have but you're also more than welcome to follow your suggestion.

 

[Sworder]

Already have but you're also more than welcome to follow your suggestion.

So how long do the macros stay in your bloodstream before turned into calories or do they never?
What does turn into calories?
What's the glycemic index?

This is like basic diet info. Protein and carbs have 4 calories, fat has 9.

 

[Docd187123]

So how long do the macros stay in your bloodstream before turned into calories or do they never?
What does turn into calories?
What's the glycemic index?

This is like basic diet info. Protein and carbs have 4 calories, fat has 9.

Macros don't get broken down to calories. Protein gets turned to amino acids for example and carbs turn to glucose.

Calorie is a unit of measure. That's like asking what does turn into a foot. Or what does turn into a pound.....

The glycemic index is a waste of breath to talk about. It's a completely worthless measure for anyone except maybe diabetics.

If it's so basic why are you continually getting it wrong?

 

[Sworder]

What gets turned into calories then?


Yes calories are a unit of measurement for X grams macro.
For a meal:
100 g carbs 400 cal
200 g protein 800 cal
50 grams fat 450cal
=1650 calories

Is that incorrect? I must have missed basic dieting.
So if I am trying to get 5500 calories for my bulk cycle and Macros are NOT what turns into calories how do I plan to achieve that?

Either way we can agree to disagree. I am just curious on what you think calories are made from or what happens to the macros.

 

[Oregongearhead]

Clenbuterol-Induced Tardive Dyskinesia
http://journals.lww.com/clinicalneu...clenbuterol_induced_tardive_dyskinesia.6.aspx


Obviously Tardive Dyskinesia isn't something relevant for the BB community that use it as a fatburner. My point is:

LESS DRUGS IS BETTER STOP FUCKING WITH TOO MUCH SHIT AND GET OFF YOUR ASS AND RUN

Gotta side with Sworder on this one , get-off your lazy asses and burn calories . Stop looking for a pill or substance to do it for you . Clen , Albuterol are hard on the heart , plus I hate that amphetamine feeling , jittery and sweaty with my heart pounding .
Cant sleep .

Screw that sht I"ll take that slightly longer and safer road and add in some cardio . I can lose a lb/day easy once I add cardio (treadmill twice daily/20min each) is all it takes . Plus 500 less than maintance calories (around 2000 for me).

 

[Sworder]

Macros don't get broken down to calories. Protein gets turned to amino acids for example and carbs turn to glucose.

Gotta side with Sworder on this one , get-off your lazy asses and burn calories . Stop looking for a pill or substance to do it for you . Clen , Albuterol are hard on the heart , plus I hate that amphetamine feeling , jittery and sweaty with my heart pounding .
Cant sleep .

@Oregongearhead Do macros turn into calories?

 

[Dwizzle]

There is nothing true in this statement sorry. It couldn't be further from the truth.



It has nothing to do with me working out but the fact I tailor my intake to my stats and goals. It just so happens that I finish training usually around 10pm so I eat a shit ton when I get home.



It has to do with the macronutrients not the calories or amount of food.



Again, this is incorrect. You're severely overestimating the power of insulin. You think being hypocaloric but drinking 900cals of juice at bedtime will cause fat? There's more to it than that and the answer is highly unlikely as DNL is grossly overstated in the BB world. The idea humans turn carbs to fat is based on rat models mainly but rats process carbs very differently than humans do. DNL is a rare process in humans and for it to be an issue you would need somewhere along the lines of 700-900g of carbs a day for several days straight.

Here is but one study

Am J Clin Nutr. 1987 Jan;45(1):78-85. Links
Carbohydrate metabolism and de novo lipogenesis in human obesity.

Acheson KJ, Schutz Y, Bessard T, Flatt JP, Jéquier E.
Respiratory exchange was measured during 14 consecutive hours in six lean and six obese individuals after ingestion of 500 g of dextrin maltose to investigate and compare their capacity for net de novo lipogenesis. After ingestion of the carbohydrate load, metabolic rates rose similarly in both groups but fell earlier and more rapidly in the obese. RQs also rose rapidly and remained in the range of 0.95 to 1.00 for approximately 8 h in both groups. During this time, RQ exceeded 1.00 for only short periods of time with the result that 4 +/- 1 g and 5 +/- 3 g (NS) of fat were synthesized via de novo lipogenesis in excess of concomitant fat oxidation in the lean and obese subjects, respectively. Results demonstrate that net de novo lipid synthesis from an unusually large carbohydrate load is not greater in obese than in lean individuals.


^^^^ that's 2000calories of sugar, 500g, and the amount of fat synthesized through DNL was about 4g or a whopping 36calories worth of fat.



I agree with this last part

Adrenalin is also way up during REM sleep from what I understand. Your body does lots of work while you sleep. Hence why making sure you are getting enough is SO important whether you are working out or not.

 

[Docd187123]

Adrenalin is also way up during REM sleep from what I understand. Your body does lots of work while you sleep. Hence why making sure you are getting enough is SO important whether you are working out or not.

I have not read up on adrenaline during sleep but you're right the body does not shut down all it's biological processes while you sleep and all of a sudden magically turn macros to fat.

 

[Oregongearhead]

@Oregongearhead Do macros turn into calories?

Macros are calories , they are simply the food we eat ....

Bodybuilding.com : But first, what does "to macro" mean? "To macro" means tracking the number of grams of http://www.bodybuilding.com/store/protein.htm, http://www.bodybuilding.com/store/carbs.htm, and fats you consume on a particular day.

Each macronutrient yields a certain number of calories.

• One gram of protein yields 4 calories.
• One gram of carbohydrate yields 4 calories.
• One gram of fat yields 9 calories.
• One gram of alcohol yields 7 calories.

 

[CensoredBoardsSuck]

Macros don't get broken down to calories. Protein gets turned to amino acids for example and carbs turn to glucose.

Calorie is a unit of measure. That's like asking what does turn into a foot. Or what does turn into a pound.....

The glycemic index is a waste of breath to talk about. It's a completely worthless measure for anyone except maybe diabetics.

If it's so basic why are you continually getting it wrong?

Docd, I don't know where you find the patience to converse with this clown and still remain civil but you should be commended. Even though the information you've presented is beyond Sworder's ability to comprehend, it will still benefit others. Your example proves that even in the face of idiocy, it is still possible to remain on topic and provide beneficial information. That's not an easy thing to do. Hat's off, sir.

 

[Sworder]

Macros are calories , they are simply the food we eat ....

Bodybuilding.com : But first, what does "to macro" mean? "To macro" means tracking the number of grams of http://www.bodybuilding.com/store/protein.htm, http://www.bodybuilding.com/store/carbs.htm, and fats you consume on a particular day.

Oh okay. Just making sure I wasn't going completely insane. Thanks.

 

[MrRippedZilla]

I have not read up on adrenaline during sleep but you're right the body does not shut down all it's biological processes while you sleep and all of a sudden magically turn macros to fat.

Not to mention the fact that GH is very high while you sleep to increase lipolysis....

Or that Leptin is also very high while you sleep, completely counterintuitive to the BS argument that your body SUDDENLY becomes a fat storing machine at night....

 

[Sworder]

Not to mention the fact that GH is very high while you sleep to increase lipolysis....

Or that Leptin is also very high while you sleep, completely counterintuitive to the BS argument that your body SUDDENLY becomes a fat storing machine at night....

Lol I never said that, a 200lb person will burn about 90-100 calories/hour during sleep. If you ingest a 2000 calories meal before sleep that takes 0.5-3 hours to digest. The extra calories will become FAT. Y'all going HAM on BMR during sleep to help circle jerk around the idiocy around not understanding macros and calories? I love it, I LIKE IT!

 

[Dwizzle]

Big meal before sleeping usually converts the calories especially fast carbs to fat as you are not using/burning them. It's one of the biggest things I have personally seen help people. Not doing a big meal before bedtime and if needed do a slow digesting meal oatmeal + protein.

You can do it because you work out, but it's very common for people whom are obese to eat huge high calorie snacks before bedtime. It helps sleeping too as the body induces "food coma."

I see it as a graph in my head of how much calories or food is currently circulating and how the body's response will be.

I usually drink juice throughout the day and that keeps a constant low spike of glucose to be readily available for my body. Drinking that gallon of juice (900calories) before bedtime would surely result in too much energy and it will convert to fat.

Many males that are obese have high e2 and a TRT dose can help during the phase of transitioning from obese -> normal/fit. Testosterone effects the lipolysis rate and the lack of testosterone can also lead to less energy levels throughout the day and becomes an evil circle.

He agreed with your last paragraph. The rest he refuted.

Your argument was not that it turns to calories when you go to bed, it was that these calories you eat especially fast carbs turn to fat because you are not using them!

As @Docd187123 said a "calorie" is simply a unit of measure. You macros get turned into amino acids and all sorts of other goodies aside from fats!

 

[Dwizzle]

Lol I never said that, a 200lb person will burn about 90-100 calories/hour during sleep. If you ingest a 2000 calories meal before sleep that takes 0.5-3 hours to digest. The extra calories will become FAT. Y'all going HAM on BMR during sleep to help circle jerk around the idiocy around not understanding macros and calories? I love it, I LIKE IT!

Who the hell eats one meal that is 2000 calories? You are reaching my friend...

 

[Dwizzle]

You go from talking about drinking a large amount of juice to a 2000 calorie meal.... smh

 

[Dwizzle]

You have to admit @Sworder your argument has went a little out of bounds man considering what you were originally talking about

 

[Sworder]

Your argument was not that it turns to calories when you go to bed, it was that these calories you eat especially fast carbs turn to fat because you are not using them!

I stand fast by this. Ok, make it a 1k calorie meal. A gallon of juice, larger amount(larger for small people lol) of ice cream or a big brownie.
It will turn into fat unless you are keeping to what your BMR is during sleep.

For people that don't exercise this is particularly true, for BBs it isn't as when we go on a surplus diet many of the macros get "used" differently because instead of storing as fat it builds new muscle. However if you don't workout the body won't build new muscle with it and it will convert to fat instead.

It's a simple numbers game. Eat 1000 calories and burn 400 and the extra 600 will be stored in your body. I am not reaching for anything. It's pretty simple, X amount of calories and Y time it takes to convert it to calories are the only things you need to consider.

It's not getting taken out of context. When the circlejerk is wrong they:
1. Deflect.
2. Change the subject.
3. Attack the person.

 

[MrRippedZilla]

I stand fast by this. Ok, make it a 1k calorie meal. A gallon of juice, larger amount(larger for small people lol) of ice cream or a big brownie.
It will turn into fat unless you are keeping to what your BMR is during sleep.

For people that don't exercise this is particularly true, for BBs it isn't as when we go on a surplus diet many of the macros get "used" differently because instead of storing as fat it builds new muscle. However if you don't workout the body won't build new muscle with it and it will convert to fat instead.

It's a simple numbers game. Eat 1000 calories and burn 400 and the extra 600 will be stored in your body. I am not reaching for anything. It's pretty simple, X amount of calories and Y time it takes to convert it to calories are the only things you need to consider.

It's not getting taken out of context. When the circlejerk is wrong they:
1. Deflect.
2. Change the subject.
3. Attack the person.

Based on all this, would you care to explain why endurance athletes carb load at night (5k+ cals) and wake up with fully replenished muscle glycogen levels & no increase in fat mass? And no, they aren't using it to "build muscle"

Your unaware that the natural response to a large meal is to inhibit FFA release but then rapidly INCREASE it 3-4 hours after the meal (also notice how "smaller" meals actually blunt FFA release MORE):
http://www.ncbi.nlm.nih.gov/pubmed/2191884
This process does NOT change because your sleeping.

Your also missing the forest for the trees - your so focused on the BMR during sleep (8hrs~) that your ignoring the FACT that it all evens itself out over the course of a day, week, month, etc if the overall calories/macros are the same.

 

[Sworder]

Based on all this, would you care to explain why endurance athletes carb load at night (5k+ cals) and wake up with fully replenished muscle glycogen levels & no increase in fat mass? And no, they aren't using it to "build muscle"

Your unaware that the natural response to a large meal is to inhibit FFA release but then rapidly INCREASE it 3-4 hours after the meal (also notice how "smaller" meals actually blunt FFA release MORE):
http://www.ncbi.nlm.nih.gov/pubmed/2191884
This process does NOT change because your sleeping.

Your also missing the forest for the trees - your so focused on the BMR during sleep (8hrs~) that your ignoring the FACT that it all evens itself out over the course of a day, week, month, etc if the overall calories/macros are the same.

Different subject, remember you brought it up. We are talking about people changing their lifestyle.

No, I do not agree that it evens itself out over the course of the day. That is completely wrong. Just like I do, I drink juice throughout the day. There is a large difference in how the macros/calories are used when drinking the whole gallon in the morning which is 900 calories vs drinking it throughout the day.

I gotta baby sit some other people now, don't have time for y'all right now. I don't quite know what your point is beyond the "it balances itself out throughout the day" and I do not agree with that. Timing is extremely important.