CagriSema's going nowhere: a cautionary tale

[Ghoul]

Despite very promising initial results, as the clinical trials expanded, it looks increasingly mediocre. Very late in development for this disappointment to be revealed by Novo, but a reminder drug developers don't *have* to deliver bad news until they decide to. It's only required if they are putting the drug on the market.

With no release date yet revealed by Eli, I wonder what surprises await us with Reta.

IMO, those new to GLPs would be better off staying on the beaten path with proven winners, and keeping a large chunk of cash in their pockets, choosing Sema or Tirz. You can always upgrade later.

https://www.cnbc.com/2025/03/10/novo-nordisk-shares-fall-after-cagrisema-weight-loss-drug-trial-result.html

 

[noteablequotable]

I think in this landscape where price and access continue to be hot topics CagriSema has value. If it's only as effective as Tirzepatide that's good enough for a doctor to prescribe it when Tirz is unavailable or more expensive/not covered by insurance.

I've also heard some rumblings that CagriSema is more effective in people who have metabolic issues (I think one of the people who mentioned this was Lyle). If that's the case it may be even more valuable for that particular demographic. Maybe I should call Novo and yell at them

 

[SnowyMiami]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

 

[Ghoul]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

I'm sure Novo will make some use of it if there's any justifiable reason to do so. If they can it and walk away from tens or hundreds of millions in development costs that's a pretty good sign. it wasn't worth it.

 

[AlexDavis43]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

There are a few studies on pramlintide, another amylin agonist, alone and in combination with metreleptin (a leptin analog). Looked promising but fell off the radar.

 

[quarter]

Cagri was a huge bust for me (i know n=1). Just exhaustion in a vial

 

[SBD1]

Tirz give me tummy aches and works so well at killing my appetite I struggle to eat until the blood levels stop falling a few days post injection.

Reta is amazing low dose. I’ll take my chances, better quality of life. For now.

 

[SnowyMiami]

Tirz give me tummy aches and works so well at killing my appetite I struggle to eat until the blood levels stop falling a few days post injection.

Reta is amazing low dose. I’ll take my chances, better quality of life. For now.

Does the Reta provide any appetite suppression?

 

[SnowyMiami]

Cagri was a huge bust for me (i know n=1). Just exhaustion in a vial

What is the deal with people saying you can not drink alcohol on Cagri at all? What happens?

 

[SBD1]

Does the Reta provide any appetite suppression?

Some, not as much as Tirz/sema. It mostly kills the food noise which helps a lot. But I never get close to the 3mg/wk that people recommend. 1mg e5d is plenty for me to get what I want out of it.

 

[quarter]

What is the deal with people saying you can not drink alcohol on Cagri at all? What happens?

I can't answer that, as sema made me quit drinking because it just isn't fun anymore. I can say that I was sleeping 9-10 good quality (measured by ring, bed sensor and cpap) hours and was still a walking zombie. Shit was crazy.

And it didn't smash my hunger or anything. Sema did all the heavy lifting for sure.

 

[Corduroy]

I've felt cagri was doomed for a long time now, simply given so many reports of profound exhaustion from so many early adopters. The fact that sema/cagri combination works no better for weight loss than tirz alone is just another nail in the coffin. Eli Lilly is now in an extremely good position with upcoming orforglipron (daily pill, small molecule, same mechanism as tirzepatide) and retatrutide.

 

[SnowyMiami]

I've felt cagri was doomed for a long time now, simply given so many reports of profound exhaustion from so many early adopters. The fact that sema/cagri combination works no better for weight loss than tirz alone is just another nail in the coffin. Eli Lilly is now in an extremely good position with upcoming orforglipron (daily pill, small molecule, same mechanism as tirzepatide) and retatrutide.

Some people on here who are already lean like Cagri solo because it just changes
motivation/reward without messing with your digestion.

 

[Corduroy]

I'm happy it works for them and that they can tolerate it. It will be interesting to get some good real-world data on the side effect of fatigue because I strongly suspect the rate is much, much higher than what has been published by the studies run by Novo Nordisk so far.