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CagriSema's going nowhere: a cautionary tale

Ghoul

Ghoul

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Despite very promising initial results, as the clinical trials expanded, it looks increasingly mediocre. Very late in development for this disappointment to be revealed by Novo, but a reminder drug developers don't *have* to deliver bad news until they decide to. It's only required if they are putting the drug on the market.

With no release date yet revealed by Eli, I wonder what surprises await us with Reta.

IMO, those new to GLPs would be better off staying on the beaten path with proven winners, and keeping a large chunk of cash in their pockets, choosing Sema or Tirz. You can always upgrade later.

 
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I think in this landscape where price and access continue to be hot topics CagriSema has value. If it's only as effective as Tirzepatide that's good enough for a doctor to prescribe it when Tirz is unavailable or more expensive/not covered by insurance.

I've also heard some rumblings that CagriSema is more effective in people who have metabolic issues (I think one of the people who mentioned this was Lyle). If that's the case it may be even more valuable for that particular demographic. Maybe I should call Novo and yell at them
 
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SnowyMiami said:
Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?
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I'm sure Novo will make some use of it if there's any justifiable reason to do so. If they can it and walk away from tens or hundreds of millions in development costs that's a pretty good sign. it wasn't worth it.
 
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Tirz give me tummy aches and works so well at killing my appetite I struggle to eat until the blood levels stop falling a few days post injection.

Reta is amazing low dose. I’ll take my chances, better quality of life. For now.
 
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SnowyMiami said:
What is the deal with people saying you can not drink alcohol on Cagri at all? What happens?
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I can't answer that, as sema made me quit drinking because it just isn't fun anymore. I can say that I was sleeping 9-10 good quality (measured by ring, bed sensor and cpap) hours and was still a walking zombie. Shit was crazy.

And it didn't smash my hunger or anything. Sema did all the heavy lifting for sure.
 
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I've felt cagri was doomed for a long time now, simply given so many reports of profound exhaustion from so many early adopters. The fact that sema/cagri combination works no better for weight loss than tirz alone is just another nail in the coffin. Eli Lilly is now in an extremely good position with upcoming orforglipron (daily pill, small molecule, same mechanism as tirzepatide) and retatrutide.
 
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Corduroy said:
I've felt cagri was doomed for a long time now, simply given so many reports of profound exhaustion from so many early adopters. The fact that sema/cagri combination works no better for weight loss than tirz alone is just another nail in the coffin. Eli Lilly is now in an extremely good position with upcoming orforglipron (daily pill, small molecule, same mechanism as tirzepatide) and retatrutide.
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Some people on here who are already lean like Cagri solo because it just changes
motivation/reward without messing with your digestion.
 
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I'm happy it works for them and that they can tolerate it. It will be interesting to get some good real-world data on the side effect of fatigue because I strongly suspect the rate is much, much higher than what has been published by the studies run by Novo Nordisk so far.
 
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Corduroy said:
I've felt cagri was doomed for a long time now, simply given so many reports of profound exhaustion from so many early adopters. The fact that sema/cagri combination works no better for weight loss than tirz alone is just another nail in the coffin. Eli Lilly is now in an extremely good position with upcoming orforglipron (daily pill, small molecule, same mechanism as tirzepatide) and retatrutide.
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Cagrisema not working any better than tirz isn’t the death blow. It’s still better than any product Novo has approved today. Novo has to work with what they’ve got. The death blow is that it’s not any better, and perhaps worse, than high-dose sema.
 
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SubparMarioBro said:
Cagrisema not working any better than tirz isn’t the death blow. It’s still better than any product Novo has approved today. Novo has to work with what they’ve got. The death blow is that it’s not any better, and perhaps worse, than high-dose sema.
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But Novo isn't just competing with itself. It's competing with Eli Lilly, which owns branded tirzepatide and also branded retatrutide once it's approved, and branded oral orforglipron which will be approved before either of those. Add to that the fact that Cagrisema apparently isn't even stable when the two ingredients are mixed together, so they have to use some kind of expensive dual-chamber pen. It's just an all-around clusterfuck.
 
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Corduroy said:
But Novo isn't just competing with itself. It's competing with Eli Lilly, which owns branded tirzepatide and also branded retatrutide once it's approved, and branded oral orforglipron which will be approved before either of those. Add to that the fact that Cagrisema apparently isn't even stable when the two ingredients are mixed together, so they have to use some kind of expensive dual-chamber pen. It's just an all-around clusterfuck.
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If this was an actual competitive market Novo would be in big trouble right now. But it’s not a competitive market. It’s a duopoly with two players (Novo and Lilly) who are both more interested in milking the maximum amount of taxpayer dollars out of Medicare than actually competing with each other.

Lilly’s got better products, and they’re cheaper to produce than Novo’s best products. I’d much rather be in Lilly’s shoes. But Lilly’s so fantastically overpriced that there’s miles and miles of room for Novo to make a handsome profit even though their product is worse and more expensive to produce.
 
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I do think Cagri/Sema will eventually make it to the market, but only to compete with the numbers that Eli Lilly have going for them. Sema resulted in a net loss of around 15% while Tirz resulted in a net loss of 20%. When stacked with Sema, Cagri netted a similar 20%. From personal experience, Cagri works wonders on appetite supression and making food just taste/look, bland. It does knock you on your ass though. Even at 0.25, the fatigue is noticeable, and I've gone all the way up to 1mg before. There's also the talks that, depending on how stable the medication is, that amylin fibroids could form and increase the risk of dementia which, honestly, not sure exactly how true that statement is due to the blood/brain barrier.
 
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