Update here.
Im going to reach the conclusion, after 2 weeks of using the oral transmucosal route of administration, that there seems to be a limit on how many mg of active you can successfully intak3 in any given time frame... and it se3ms to be low. After 2 weeks i started feeling like shit despite attempting to intake huge doses, so i made up some homebrew topical using 10% USP grade DMSO and 90% of a 70% isopropyl alcohol/30% water solution at 25mg/ml test base and applied copious amounts over the course of a day, around 1000mg. By the 3nd of the day i felt substantially better so ive swi5ched to solely topical t base use for the past 6 days. Nearing the end of 3rd we3k into cycle and up 13lbs. Might pull liv values and t levels soon.
Anyways the study below is noteworthy here:
J Clin Endocrinol Metab. 1991 May;72(5):1054-9.
Sublingual administration of testosterone-hydroxypropyl-beta-cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men.
Stuenkel CA1,
Dudley RE,
Yen SS.
Author information
Abstract
In search of a more physiological testosterone (T) replacement therapy for hypogonadal states, we evaluated an inclusion complex of T with 2-hydroxypropyl-beta-cyclodextrin (HPBCD). HPBCD enhances T solubility and absorption, but HPBCD is not absorbed. Five hypogonadal men (mean age, 32.4 +/- 2.3 yr) with serum T levels below the normal range were treated in two separate experimental phases with either a 2.5- or 5.0-mg tablet of sublingual (SL) T-HPBCD three times daily for 7 days. Acute pharmacodynamic changes were monitored at baseline and 10, 20, and 40 min and 1, 1.5, 2, 3, 4, and 8 h after administration of the first dose. At the 5-mg dose, a maximal concentration (Cmax) of T (85.4 +/- 11.0 nmol/L) was achieved in 20 min (63 +/- 24-fold increase), followed by a rapid decline to below the normal range (less than 12 nmol/L) at 2 h, with an estimated half-life of decline of 1.87 +/- 0.19 h. The dihydrotestosterone (DHT) Cmax (4.1 +/- 0.5 nmol/L) occurred at 32 +/- 5 min (8.9 +/- 1.3-fold increase) and declined to below the normal range (less than 1.2 nmol/L) after 3 h. The integrated 8 h value for the ratio of T/DHT was 10.0 +/- 1.1, which fell within the normal range. The increment in androstenedione paralleled that in T, and the Cmax (6.8 +/- 0.9 nmol/L) was reached in 24 +/- 4 min (2.3 +/- 0.6-fold increase). Compared to baseline, the Cmax was significantly greater for T (P less than 0.005), DHT (P less than 0.0005), and androstenedione (P less than 0.005). Both estradiol (E2) and estrone (E1) remained in the normal range (less than 200 pmol/L), although the Cmax for E1 was significantly greater than baseline (P less than 0.05). Serum LH levels were suppressed (19.0 +/- 2.6%) at 2 h (P less than 0.05), without a significant change in FSH. During 7 days of treatment, there was no cumulative increase in basal T, DHT, and E2 levels or further decline in LH or FSH levels. There was no change in sex hormone-binding globulin levels.
Similar results were observed with the 2.5-mg dose, suggesting that the capacity of SL absorption may be limited to a certain dose of T-HPBCD. The fluctuations in T after SL administration of T-HPBCD resemble endogenous episodic secretion. We conclude that T, complexed with HPBCD, is rapidly absorbed by the SL route and quickly metabolized without sustained elevations of DHT or E2.
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The above study seems to suggest support for this observation i had.
Right now im using a hom3brew of 70% DMSO, 10% propylen3 glycol, 10% polyethylene glycol 400, 10% ethyl alcohol with a t base concentration of 100mg/ml. It doesnt irritate my skin, however i apply a layer of Phlogel Ultra a minute or two later. No HPBCD involved. Im applying 3x a day right now, usually around 1ml at a time. But this is likely to be tweaked.
I think for HPBCD use in my anecdotal experiences intranasal would b3 th3 best bet unless you only need to deliver a very low dosage such as cheque drops or som3thing then sublingual may be viable. Its too bad the t base se3ms to irritate m6 throat after intranasal ROA which makes tha5 less attractive of a route but that may no5 be the case with other AAS administered that way. Youd have to find out for yoirself as its outside of my scope. It seems to deliver the T very well this way and its very easy to dose with a nasal sprayer, plus discrete if you buy a lab3led sprayer and wash out its original contents
Also HPBCD has alot of potential for aqueous injectable bases. Its not someth8ng i intended to go deep into. But i may st8ll do more experiments with that, if i do ill post my observations here. Im sure base AAS plus HPBCD in the hands of an experi3nced brewer could yeild some novel stuff.
