Different Shbg Reaction with Exogenous Testosterone and enclomiphene

[perlanera123]

Hi everyone
I have a question:

Why do SHBG decrease with testosterone injections while they increase with the administration of enclomiphene?

If the result should be the same (increase in testosterone) why does it decrease in the case of T injections and increase with internal hormonal stimulation (ecnlomihpene/clomiphene)?

Sorry for the stupid question but I can't understand it

Thanks

 

[Sector]

"When exogenous testosterone is administered through injections, it can lead to an increase in circulating testosterone levels. Higher levels of testosterone can suppress the production of SHBG by the liver. Testosterone has a negative feedback effect on the liver, reducing the synthesis of SHBG. As a result, when testosterone levels rise due to injections, SHBG levels tend to decrease, freeing up more testosterone to be available for biological activities. This can lead to an increase in free or bioavailable testosterone in the bloodstream."

"Unlike exogenous testosterone, enclomiphene doesn't directly suppress the liver's production of SHBG. Instead, it enhances the natural production of testosterone, and the increased testosterone levels may lead to a rise in SHBG production by the liver."

"In summary, the changes in SHBG levels with testosterone injections and enclomiphene administration are primarily related to how these treatments influence testosterone levels and the subsequent feedback mechanisms on SHBG synthesis in the liver."

 

[perlanera123]

"When exogenous testosterone is administered through injections, it can lead to an increase in circulating testosterone levels. Higher levels of testosterone can suppress the production of SHBG by the liver. Testosterone has a negative feedback effect on the liver, reducing the synthesis of SHBG. As a result, when testosterone levels rise due to injections, SHBG levels tend to decrease, freeing up more testosterone to be available for biological activities. This can lead to an increase in free or bioavailable testosterone in the bloodstream."

"Unlike exogenous testosterone, enclomiphene doesn't directly suppress the liver's production of SHBG. Instead, it enhances the natural production of testosterone, and the increased testosterone levels may lead to a rise in SHBG production by the liver."

"In summary, the changes in SHBG levels with testosterone injections and enclomiphene administration are primarily related to how these treatments influence testosterone levels and the subsequent feedback mechanisms on SHBG synthesis in the liver."

thank you so much for the answer, you were very clear.

when you say that: "... Testosterone has a negative feedback effect on the liver, reducing the synthesis of SHBG..." do you mean that the testosterone spike due to the injection directly affects liver enzymes and therefore also SHBG?

Testosterone treatment improves liver function and reduces cardiovascular risk: A long-term prospective study - PMC

Objectives: To report the association between testosterone treatment in hypogonadal men with hepatic steatosis, non-alcoholic fatty liver disease and cardiovascular disease (CVD). Methods: A prospective study was conducted to assess the ...

www.ncbi.nlm.nih.gov

while with "natural production" this doesn't happen because it isn't "read by the body" as an external signal?

Thanks

 

[Sector]

thank you so much for the answer, you were very clear.

when you say that: "... Testosterone has a negative feedback effect on the liver, reducing the synthesis of SHBG..." do you mean that the testosterone spike due to the injection directly affects liver enzymes and therefore also SHBG?

Testosterone treatment improves liver function and reduces cardiovascular risk: A long-term prospective study - PMC

Objectives: To report the association between testosterone treatment in hypogonadal men with hepatic steatosis, non-alcoholic fatty liver disease and cardiovascular disease (CVD). Methods: A prospective study was conducted to assess the ...

www.ncbi.nlm.nih.gov

while with "natural production" this doesn't happen because it isn't "read by the body" as an external signal?

Thanks

Should have clarified that exogenous testosterone causes the negative feedback loop.

And yes