DNP - Danger signs?

[BalrogRebel]

Hello.
So, I'm curious about DNP, and what could danger signs be. I know what it would do at higher dosages (lethargy, and most importantly overheating), but I wonder if there is a point where you'd be able to tell "ok, this is starting to be too much". Obviously you need to "listen to your body", but with these kinds of compounds it may not be easy to understand whether you are being "too cautious and worried over nothing" (which I'm sure plenty of you are already itching to write, "you must be careful, when in doubt scale it down/don't do it to be safe"), or whether you are actually treading into danger territory.

Also: yellow-tinted jizz when on DNP -- is that expected? lol

 

[Logan44551]

There a DNP sticky I'd start out reading that. Then search posts from @Eman with dnp he is a wealth of knowledge about dnp. Yes to the yellow cum

 

[Eman]

If your body temperature reaches 99.2/99.3 degrees fahrenheit - you are treading into dangerous territory. In what was probably the most extensive human study of DNP (Simkins 1937), body temperatures that rose to 99.2 degrees became the benchmark for impending toxicity. They found that temperature was really the best, perhaps the only, marker they could monitor to prevent a reaction.

Aside from that, there's not really many other things to track... DNP has not been shown to consistently alter health markers. Pins and needles in your hands and feet can be a bad sign, out of breath at rest IS a bad sign. Paying attention to your body is advisable, you will probably know when it's time to dial things back and evaluate

Don't just accept misery as a side effect that has to happen. It might be tempting to go balls to the wall because you want to watch fat melt off... Don't do that. It might be surprising to read but, many of the original study participants noted an enhanced sense of wellbeing while taking DNP. Now, isn't that a contrast to what you read about DNP on forums? It says to me that people struggle to find ideal dosages for themselves and take too much.

TL;DR - 99.2 degrees = bad, don't make yourself miserable... Unless you enjoy sweating.

 

[TrennedOutLunatic]

Pins and needles.

The name is peripheral neuropathy.

You drop dnp on the first sign of such shit.

 

[m314]

You can get great results without much risk at low doses like 200 mg/day. If it stops working well, a 2 week break will reset your tolerance. There's no need to push things until you get to a point where it's dangerous.

 

[lifter6973]

Remember too the effect is cumulative. Start low and see how you feel after a week at least before upping the dose or you might just be fucked.
In fact, use DNP as a last resort IMO.
For newbies, definitely do not start over 250 mg per day and no longer than a 14 day cycle.
Ideally I think noobs should start at 100 to 150 mg a day for a 7 day cycle.
You pretty much can't take the shit feeling, sweating all time and being tired as fuck once you get into the middle of week 2 at 250 mg a day if you are not used to it. I haven't used it much but I cut a planned 14 day into 10 days once because I had enough.

 

[Eman]

Peripheral neuropathy associated with DNP use is something I really wish there was more information on... and I suppose there are a handful of scientists that share that wish with me.

Unfortunately, the mechanism for it occurring is something that just is not fully understood. Some of the research appears completely contradictory as well, because DNP has been studied for it's potential use in optic neuropathy with success... Kind of crosses some guesses of it's MOA off the list.

I would very much like to see more studies on DNP's effects on inhibition of L carnitine uptake. A very rare symptom of carnitine deficiency is PN, but PN is also a rare side effect of DNP use. I have wondered for a while if there is a correlation but there's very little research on this. I tend to think it would be an idea to stack the two, not only on the potential PN front but it's become all the rage as a cutting accessory lately too.

With all that said, what a lot of DNP users think is PN often turns out to be edema from the water retention. So, pins and needles aren't necessarily the end of the world if they happen... But definitely time to pay attention.

 

[TrennedOutLunatic]

With all that said, what a lot of DNP users think is PN often turns out to be edema from the water retention. So, pins and needles aren't necessarily the end of the world if they happen... But definitely time to pay attention.

Very possible

 

[hightest]

If your body temperature reaches 99.2/99.3 degrees fahrenheit - you are treading into dangerous territory. In what was probably the most extensive human study of DNP (Simkins 1937), body temperatures that rose to 99.2 degrees became the benchmark for impending toxicity. They found that temperature was really the best, perhaps the only, marker they could monitor to prevent a reaction.

Aside from that, there's not really many other things to track... DNP has not been shown to consistently alter health markers. Pins and needles in your hands and feet can be a bad sign, out of breath at rest IS a bad sign. Paying attention to your body is advisable, you will probably know when it's time to dial things back and evaluate

Don't just accept misery as a side effect that has to happen. It might be tempting to go balls to the wall because you want to watch fat melt off... Don't do that. It might be surprising to read but, many of the original study participants noted an enhanced sense of wellbeing while taking DNP. Now, isn't that a contrast to what you read about DNP on forums? It says to me that people struggle to find ideal dosages for themselves and take too much.

TL;DR - 99.2 degrees = bad, don't make yourself miserable... Unless you enjoy sweating.

99,2 isn't even a very high temperature.

 

[Eman]

99,2 isn't even a very high temperature.

No, it doesn't even constitute a fever... I agree. But, it's a signal that if you don't lower your dose or stop the drug entirely - your body temp is going to keep going up until you can't manage it anymore.

I think there might be a common DNP misconception that your body temp goes up with DNP. It certainly can but it's not typical. The human body is really remarkable in the way it can thermoregulate. My body temp, even though my skin might feel hot, is almost always lower than normal with DNP.

 

[TrennedOutLunatic]

My temperature was not increased at 200mg
Just mentioning it.

 

[Cashton]

Pins and needles.

The name is peripheral neuropathy.

You drop dnp on the first sign of such shit.

IV’d too much ketamine once as a stupid teenager and experienced pins and needles for almost an hour.. however long it took to drive from where I was to Toronto. Oops.

 

[StorGuillermoKardamo]

IIRC it is being studied again, or has been recently, as an obesity treatment at 25mg/day with minimal to no adverse effects.

 

[Eman]

IIRC it is being studied again, or has been recently, as an obesity treatment at 25mg/day with minimal to no adverse effects.

It's actually being studied for a wide array of diseases... Alzheimer's, MS, Huntingtons, ALS, parkinson's. Basically any neurodegenerative disease, as well as obesity and comorbidities associated with obesity (diabetes, nonalcoholic steatohepatitis (NASH), metabolic syndrome, cardiovascular disease). Essentially, any disease that results in acceleration of aging... Possibly even aging itself because it's been theorized that DNP can lengthen lifespan outside of the treatment of diseases that would/could shorten it.

The FDA has given Mitochon Pharmaceutical, Inc an investigational new drug approval to study safety and tolerability in humans - that is significant. It's the first time pharmacokinetic profiling in humans will be done, at least to this extent. It's entirely possible that DNP will be used as a medicine for a wide range of medical conditions all the way from being overweight to traumatic brain injury.

I'm very excited to see what happens with the research. The studies are apparently going for very very conservative doses that would, based on my knowledge and experience, be not only tolerable but probably not even noticeable. They are not going to take weight into account at all, just give patients a baseline dose.

 

[RebornNez]

Well they are also studying dnp derivatives too like bam15 very exciting

 

[darock]

Not trying to hijack this thread, however I was was researching "UnCouplers of Oxidative Phosphorylation" and it landed me here. I was lurking and read some interesting thoughts and information t. Let me get to the purpose of my post. I was looking at orally active, broad spectrum anthelmintics widely used in human and veterinary medicine shown to support Uncoupling of Oxidative Phosphorylation, I am very interest in this because I am trying to resolve a Type2 Diabetes, metabolic Syndrome issue, however the most effective meds in this category have been discontinued from the market place no longer being produce by pharma. Side Note, there where claims this group was were effective for COVID19.Thats just some background of what got me here. While researching I saw this quote "We have examined the effects of these anthelmintics on the electrical resistance of planar bimolecular lipid membranes and compared the results with those obtained with a known uncoupler, 2,4-dinitrophenol (2,4-DNP). All drugs tested markedly reduced membrane resistance at concentrations lower than 0.1 μm and were better proton conductors than 2,4-DNP by at least an order of magnitude". I had never heard of DNP. Started a google quest and it brought me to the body building forums. It seems the anthelmintics our said to be safe in the limited studies for uncoupling, DNP is alleged not so much, however despite DNP no longer approved for acceptable use as a fat reducing agent or for human consumption seems more easily sourced than the now discontinued anthelmintic drugs. I am considering DNP and have done a lot of research into this interesting substance. I have question, using low doses of DNP, anyone know if using a Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors have any contraindications. I am trying to reverse Type2 Diabetes and Fatty liver disease (FLD), also known as hepatic steatosis liver. I have followed strict protocols using diet and herbal medicines, however its a stubborn booger I don't take this lightly and always consider risk with any chemical agent I use to cause an effect, positive or negative. If you have relevant information please help me out with this.

 

[Eman]

Not trying to hijack this thread, however I was was researching "UnCouplers of Oxidative Phosphorylation" and it landed me here. I was lurking and read some interesting thoughts and information t. Let me get to the purpose of my post. I was looking at orally active, broad spectrum anthelmintics widely used in human and veterinary medicine shown to support Uncoupling of Oxidative Phosphorylation, I am very interest in this because I am trying to resolve a Type2 Diabetes, metabolic Syndrome issue, however the most effective meds in this category have been discontinued from the market place no longer being produce by pharma. Side Note, there where claims this group was were effective for COVID19.Thats just some background of what got me here. While researching I saw this quote "We have examined the effects of these anthelmintics on the electrical resistance of planar bimolecular lipid membranes and compared the results with those obtained with a known uncoupler, 2,4-dinitrophenol (2,4-DNP). All drugs tested markedly reduced membrane resistance at concentrations lower than 0.1 μm and were better proton conductors than 2,4-DNP by at least an order of magnitude". I had never heard of DNP. Started a google quest and it brought me to the body building forums. It seems the anthelmintics our said to be safe in the limited studies for uncoupling, DNP is alleged not so much, however despite DNP no longer approved for acceptable use as a fat reducing agent or for human consumption seems more easily sourced than the now discontinued anthelmintic drugs. I am considering DNP and have done a lot of research into this interesting substance. I have question, using low doses of DNP, anyone know if using a Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors have any contraindications. I am trying to reverse Type2 Diabetes and Fatty liver disease (FLD), also known as hepatic steatosis liver. I have followed strict protocols using diet and herbal medicines, however its a stubborn booger I don't take this lightly and always consider risk with any chemical agent I use to cause an effect, positive or negative. If you have relevant information please help me out with this.

You may get some more information specific to what you're looking for if you search "CRMP" with keywords like type 2 diabetes and fatty liver disease. CRMP is a derivative of DNP created for the purpose of studying it's properties with regard to those two ailments.

With that said, DNP has been studied for this purpose for some time now. I know of at least one person that uses it at least once yearly to keep rising blood glucose levels within range with success. This is not a suggestion to take it, even as someone that is a firm believer in it's usefulness... It gives me pause to actually recommend it because it is not without some risk.

Also, I'm unaware of any contraindications with the drug you mentioned. To my knowledge, it's never been studied. I can't think of any real reason it would be an issue but I'm not wholly familiar with that medicine.

 

[darock]

Thank you for your response, its greatly appreciated SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins.

They inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood. As a result, more glucose is excreted in the urine. SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure.

 

[Eman]

Thank you for your response, its greatly appreciated SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins.

They inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood. As a result, more glucose is excreted in the urine. SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure.

Yes, I have a basic understanding of it.. I just meant I'm not familiar with it enough to know for sure if there'd be an issue with combining them.

There's a bit of overlap in the MOA with them in regard to how they both interact with ATP and AMPK... I don't see it as an acutely dangerous overlap but the biology gets tremendously technical - I do not have a definitive answer.

 

[RebornNez]

I believe gw501516 can help with glucose control and fatty liver