DNP + SLIN

[peeepo2]

Why many people choise to use DNP and Slin together? Where is the worth?

“DNP certainly does block the anabolic effects of exogenous insulin as it sabotages the proton pump and interferes with Pi groups' uptake into the mitochondrial matrix, reducing substrates for ATPase.

Growth requires ATP. The practical purpose of exogenous insulin is growth. DNP works at cross-purposes with this (its purpose is fat loss and it's a very blunt instrument at that).”

 

[hudson98]

I never understood why people use DNP.

ECA stack with a low dose of tren is always what I would want to do.

I plan on seriously cutting in a few weeks using vyvanse and low dose of tren. I don’t know much about the ECA stacks. Maybe I’ll do that instead.

They use it because they don't have the will power to diet

 

[Type-IIx]

1) DNP does block the release of insulin and prevents a key component of the electron transport chain (ATP synthase, remember?), it does nothing to prevent the aforementioned extremely anabolic affect of insulin. Therefore, when you use DNP, you should be administering insulin at the same time. The exogenous insulin will still work its anabolic magic while the DNP burns off reams of body fat through the resultant metabolic increase.

2) DNP certainly does block the anabolic effects of exogenous insulin as it sabotages the proton pump and interferes with Pi groups' uptake into the mitochondrial matrix, reducing substrates for ATPase.

In the first point, it is stated that the use of exogenous insulin is really useful and keeps the anabolism active, while the fat loss generated by the metabolic increase produced by DNP continues incessantly.

In the second point, however, it is stated that DNP renders the administration of exogenous insulin useless.

Which of these two statements is closest to the reality of the facts?

I know that as the contributor of the second point in your proposed dilemma, you may prefer crowdsourcing the right answer (I would suggest that this isn't a likely method for deriving an accurate understanding of this apparent dilemma) - but let me expand the original point, as there are further important facts to consider:

DNP certainly does block the anabolic effects of exogenous insulin as it sabotages the proton pump and interferes with Pi groups' uptake into the mitochondrial matrix, reducing substrates for ATPase.

Growth requires ATP. The practical purpose of exogenous insulin is growth. DNP works at cross-purposes with this (its purpose is fat loss and it's a very blunt instrument at that).

Insulin promotes skeletal muscle hypertrophy by increased muscle protein synthesis, b) reduced proteolysis, and c) transmembrane transport of AAs (non-BCAAs).

Only one of these (b) is particularly useful in skeletal muscle with the use of DNP for the preservation of muscle and strength. I'd suggest that androgens accomplish anticatabolism in skeletal muscle at low doses better than insulin.

Now let's look at what the claimant from the first point gets wrong (it involves basic biology & energy metabolism):

1) DNP does block the release of insulin and prevents a key component of the electron transport chain (ATP synthase, remember?), it does nothing to prevent the aforementioned extremely anabolic affect of insulin. Therefore, when you use DNP, you should be administering insulin at the same time. The exogenous insulin will still work its anabolic magic while the DNP burns off reams of body fat through the resultant metabolic increase.

Whether a cell undergoes anabolic processes (e.g., AA synthesis, lipogenesis, glycogenesis) versus catabolic processes (e.g., proteolysis, β-oxidation, glycogenolysis) depends on the energy state of the cell. The purpose of DNP is to, by uncoupling of oxidative phosphorylation, increase RMR (contributing to a substantial energy deficit). When the cell is in a negative energy state (i.e., caloric restriction/deficit + DNP; as is the universal use case for DNP), anabolic processes (building macromolecules, like proteins, triglycerides, etc.) are foregone. Instead, catabolic processes (breaking down macromolecules like proteins, triglycerides, etc.) are used to provide energy to synthesize ATP. Since this is frustrated by DNP (across the inner mitochondrial membrane, proton leakage occurs), the extraneous energy is released as heat (i.e., thermogenesis/increased body temperature). As such, the anabolic functions of insulin are irrelevant given the cell's energy state; and all that becomes relevant essentially are its anticatabolic features (at which androgens are far more useful because they preferentially serve to spare muscle protein, while serving as well to maintain free T, IGF-I [particularly with testosterone], etc. - that are all reduced substantially by caloric restriction).

 

[peeepo2]

I know that as the contributor of the second point in your proposed dilemma, you may prefer crowdsourcing the right answer (I would suggest that this isn't a likely method for deriving an accurate understanding of this apparent dilemma) - but let me expand the original point, as there are further important facts to consider:




Now let's look at what the claimant from the first point gets wrong (it involves basic biology & energy metabolism):



Whether a cell undergoes anabolic processes (e.g., AA synthesis, lipogenesis, glycogenesis) versus catabolic processes (e.g., proteolysis, β-oxidation, glycogenolysis) depends on the energy state of the cell. The purpose of DNP is to, by uncoupling of oxidative phosphorylation, increase RMR (contributing to a substantial energy deficit). When the cell is in a negative energy state (i.e., caloric restriction/deficit + DNP; as is the universal use case for DNP), anabolic processes (building macromolecules, like proteins, triglycerides, etc.) are foregone. Instead, catabolic processes (breaking down macromolecules like proteins, triglycerides, etc.) are used to provide energy to synthesize ATP. Since this is frustrated by DNP (across the inner mitochondrial membrane, proton leakage occurs), the extraneous energy is released as heat (i.e., thermogenesis/increased body temperature). As such, the anabolic functions of insulin are irrelevant given the cell's energy state; and all that becomes relevant essentially are its anticatabolic features (at which androgens are far more useful because they preferentially serve to spare muscle protein, while serving as well to maintain free T, IGF-I [particularly with testosterone], etc. - that are all reduced substantially by caloric restriction).

Hey, thanks again for the reply, very helpfull therefore the SLIN, also administered around the HGH and AAS, continues to have only an anti-catabolic effect but not anabolic, due to the lack of ATP. Correct?

 

[EJ1739]

Yeah I have many times. I take 30 mg I stopped after 6 months of classes and really didn’t even. Notice.

I’ve had a script forever. Just rarely ever used it when out of school.

I also love using it to party every once in a while. Better than sucking a bag up my nose

My use is purely performance for work and studying though and I will never go over 30 mg. When it stops working I take a break for a month. It makes me way less agitated compared to adderall

It is amazing for partying haha, I just have a short fuse on it for some reason, only towards people that deserve it though haha.

Do you not find it very difficult to get up in the mornings and also crash hard in the evening's? I suppose I am on 40mg in the morning and 30mg at lunch, so that is probably why.

Yes, way less agitation that Adderall!

 

[Pineapples4Puss]

It is amazing for partying haha, I just have a short fuse on it for some reason, only towards people that deserve it though haha.

Do you not find it very difficult to get up in the mornings and also crash hard in the evening's? I suppose I am on 40mg in the morning and 30mg at lunch, so that is probably why.

Yes, way less agitation that Adderall!

70 mg a day?? That’s fuxking insane.

I did have a super hard time waking up. But that’s why I take a vyvanse and 20 min later I’m good lol. I never crashed off it. I notice by 4-5 o clock it wears off but it’s still working focus wise.

Just less energy. I also start my days at 4 am so I say this is normal.

I can’t imagine taking that much though I’d have a heart attack

 

[peeepo2]

70 mg a day?? That’s fuxking insane.

I did have a super hard time waking up. But that’s why I take a vyvanse and 20 min later I’m good lol. I never crashed off it. I notice by 4-5 o clock it wears off but it’s still working focus wise.

Just less energy. I also start my days at 4 am so I say this is normal.

I can’t imagine taking that much though I’d have a heart attack

Go open another thread for your pointless argument thanks

 

[Pineapples4Puss]

Go open another thread for your pointless argument thanks

What the fuck are you talking about? What argument where me and him having. Or with anyone?

You stupid fuck. We were having a conversation on our experiences with vyvanse?

Go fuck yourself you faggot. Thanks.

 

[Pineapples4Puss]

Go open another thread for your pointless argument thanks

5 likes and I’ll fuck this guys wife

 

[peeepo2]

View attachment 168718
5 likes and I’ll fuck this guys wife

like if someone cares about you ahaha I renew my best wishes here too fuckin worm

 

[TA13579]

You can joke! I can see better now than before I went blind. And I won’t have to have the surgery when I’m older. Cataracts don’t grow back. It was expensive, but an easy fix.

I know this is an old thread/comment but just wanted to say thanks for posting your experience about developing neuropathy and cataracts from DNP use. I had purchased a small amount out of desperation in the hope it would help me lose some weight fast, but I've learned through reading this forum that it's just simply not worth it, especially with possible damage to the eyes. Something about eye injuries just creeps me out. The possibility of going blind is absolutely too much of a risk.

Out of all the compounds in the AAS community, it's interesting that DNP is not scheduled and yet it's the most dangerous. Meanwhile weed is still a schedule 1 and half the US states have it for sale down the street for recreational use. The drug laws are completely screwed up.

If it takes me even an extra year, I'm going to just lose the weight with some TRT, GLP1s, diet and lifting.