I found a study (in rats) that might support your anecdotal report. Now, you wish for me to go further! Is this a homework assignment? LOL
MESO-Rx
Anabolic Steroids
Fun adventures with E2
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I found a study (in rats) that might support your anecdotal report. Now, you wish for me to go further! Is this a homework assignment? LOL
Just making sure you weren't comparing me to a rat! On the other hand I've been called worse......
El-Sakka AI. Impact of the association between elevated oestradiol and low testosterone levels on erectile dysfunction severity. Asian J Androl. http://www.nature.com/aja/journal/vaop/ncurrent/full/aja201320a.html
Our aim was to assess the impact of the association between elevated oestradiol (E2) and low testosterone (T) levels on erectile dysfunction (ED) severity. A total of 614 male patients with ED and a normal or low T level in association with normal or elevated E2 levels were enrolled. Patients underwent routine laboratory investigations in addition to measurements of total T, total E2, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin. We compared the responses to the erectile function domain, Q3 (achieving erection) and Q4 (maintaining erection) of the International Index for Erectile Function (IIEF) score in patients with the following: normal T and E2 levels; low T level; low T level and elevated E2 level; and elevated E2 level. Of the patients included, 449 (73.1%) had normal T and E2 levels, 110 (17.9%) had a low T level, 36 (5.9%) had a low T level and an elevated E2 level, and 19 (3.1%) had an elevated E2 level. Increased ED severity was significantly associated with low T levels, elevated E2 levels, and both a low T level and an elevated E2 level. Additionally, the mean values of the EF-domain, Q3 and Q4 were significantly lower in patients with both a low T level and an elevated E2 level compared to patients with any condition alone. In conclusion, a low T level had the primary effect on erectile function; however, a concomitantly elevated E2 level had an additive impairment effect.
Our aim was to assess the impact of the association between elevated oestradiol (E2) and low testosterone (T) levels on erectile dysfunction (ED) severity. A total of 614 male patients with ED and a normal or low T level in association with normal or elevated E2 levels were enrolled. Patients underwent routine laboratory investigations in addition to measurements of total T, total E2, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin. We compared the responses to the erectile function domain, Q3 (achieving erection) and Q4 (maintaining erection) of the International Index for Erectile Function (IIEF) score in patients with the following: normal T and E2 levels; low T level; low T level and elevated E2 level; and elevated E2 level. Of the patients included, 449 (73.1%) had normal T and E2 levels, 110 (17.9%) had a low T level, 36 (5.9%) had a low T level and an elevated E2 level, and 19 (3.1%) had an elevated E2 level. Increased ED severity was significantly associated with low T levels, elevated E2 levels, and both a low T level and an elevated E2 level. Additionally, the mean values of the EF-domain, Q3 and Q4 were significantly lower in patients with both a low T level and an elevated E2 level compared to patients with any condition alone. In conclusion, a low T level had the primary effect on erectile function; however, a concomitantly elevated E2 level had an additive impairment effect.
Impact Of Polymorphisms In The Estrogen Receptors On Erectile Dysfunction
Safarinejad MR, Taghva A, Shafiei N, Safarinejad S. Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction. Andrology. Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction - Safarinejad - 2013 - Andrology - Wiley Online Library
Erection is principally a vascular phenomenon. Oestrogen affects the vascular system in various ways. Oestrogen effects are mediated by oestrogen receptors (ERs). We examined the relationship of two polymorphisms in ESR-? (ER-1) (rs2234693 and rs9340799) and two polymorphisms in ESR-? (ER-2) (rs4986938 and rs1256049) with risk of vasculogenic erectile dysfunction (VED). The rs2234693 (ER-? PvuII), rs9340799 (ER-? XbaI), rs4986938 (ER-? AluI) and rs1256049 (ER-? RsaI) were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. Serum levels of sex hormone-binding globulin (SHBG), total testosterone, free testosterone (fT), total oestradiol (E2) and free oestradiol (free E2) were also measured. A total of 266 men with VED and 532 healthy controls were recruited into this study. The ER-? PvuII C allele (OR = 4.2; 95% CI: 2.79–8.43, p = 0.001), ER-? XbaI A allele (OR = 4.87; 95% CI: 2.75–8.64, p = 0.001), ER-? RsaI A allele (OR=0.37; 95% CI: 0.24–0.66, p = 0.001) and ER-? AluI A allele (OR = 0.29; 95% CI: 0.16–0.57, p = 0.001) were significantly associated with VED. Subjects with ER-? PvuII CC and ER-? XbaI AA genotypes had highest serum levels of E2, and subjects with ER-? RsaI AA and ER-? AluI AA genotypes had lowest serum levels of E2. Patients with lower serum levels of E2 had more sever VED and more mixed vascular type VED. In haplotype analysis, PvuII C–XbaI A increased the risk of developing VED by more than eightfold, in contrast, RsaI A–AluI A haplotype had protective effect (OR = 0.53; 95% CI: 0.34–0.76, p = 0.002). The ER-? and ER-? gene polymorphisms and haplotypes are associated with presence, type and severity of VED.
Safarinejad MR, Taghva A, Shafiei N, Safarinejad S. Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction. Andrology. Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction - Safarinejad - 2013 - Andrology - Wiley Online Library
Erection is principally a vascular phenomenon. Oestrogen affects the vascular system in various ways. Oestrogen effects are mediated by oestrogen receptors (ERs). We examined the relationship of two polymorphisms in ESR-? (ER-1) (rs2234693 and rs9340799) and two polymorphisms in ESR-? (ER-2) (rs4986938 and rs1256049) with risk of vasculogenic erectile dysfunction (VED). The rs2234693 (ER-? PvuII), rs9340799 (ER-? XbaI), rs4986938 (ER-? AluI) and rs1256049 (ER-? RsaI) were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. Serum levels of sex hormone-binding globulin (SHBG), total testosterone, free testosterone (fT), total oestradiol (E2) and free oestradiol (free E2) were also measured. A total of 266 men with VED and 532 healthy controls were recruited into this study. The ER-? PvuII C allele (OR = 4.2; 95% CI: 2.79–8.43, p = 0.001), ER-? XbaI A allele (OR = 4.87; 95% CI: 2.75–8.64, p = 0.001), ER-? RsaI A allele (OR=0.37; 95% CI: 0.24–0.66, p = 0.001) and ER-? AluI A allele (OR = 0.29; 95% CI: 0.16–0.57, p = 0.001) were significantly associated with VED. Subjects with ER-? PvuII CC and ER-? XbaI AA genotypes had highest serum levels of E2, and subjects with ER-? RsaI AA and ER-? AluI AA genotypes had lowest serum levels of E2. Patients with lower serum levels of E2 had more sever VED and more mixed vascular type VED. In haplotype analysis, PvuII C–XbaI A increased the risk of developing VED by more than eightfold, in contrast, RsaI A–AluI A haplotype had protective effect (OR = 0.53; 95% CI: 0.34–0.76, p = 0.002). The ER-? and ER-? gene polymorphisms and haplotypes are associated with presence, type and severity of VED.
lanier1974
New Member
Now, if they'd included subjective questionnaires for participants to rate levels of penis sensation, orgasm pleasure, and desire, THAT would show a lot more about the issue being discussed here.
I'm playing with aromasin alone, off cycle, charting daily quality of morning wood, levels of sexual desire, as well as quality of masturbation and sex, changing the dose or frequency every week or so.
Interesting stuff happening.
At this point, I totally accept free test is the primary factor for erection quality, as well as even keeled emotions and confidence. I'm also feeling that estrogen is the primary factor influencing sensitive feelings of love, sensitive erections and orgasms, and feelings of being horny.
Docs?
I agree....my fT is up and boners are good with great sensitivity (no AI past few months).
I'll second what's been said about Free T and E2.
id, please remind me - did you ever try T-gel? If so, how did you respond to it?
id, please remind me - did you ever try T-gel? If so, how did you respond to it?
Never tried....I tend to be a sweaty guy and have three young kids....I worried about exposing them. Test cyp is easy and affordable to me at $85 per bottle.
bltchemistry
New Member
I'LL give ya some more help. PROLACTIN is the magic number. The one everyone seems to omit around here. E2 have never hurt my wood... Ever...
MY TREE, LIKES E.....
BBC3, I find it interesting that you mentioned this because we have talked about the effect of Bupropion on prolactin levels, with the consensus that Bupropion MAY increases prolactin levels (Possibly causing gyno). What is now confusing me is that anecdotaly (and personally), Bupropion has a beneficial effect on both libido and erection quality.
Was on 500mgs test e weekly 10 weeks. First 2weeks was taking liqui aromasin 12.5mgs ed. Worst idea ever! I wouldn't wish that feeling on my worst enemy. All my joints hurt and lower back hurt so damn bad was walking bent over and honestly had to take breaks every couple of steps from the excruciating lower back pain. Skin sooo dry itching like I had poison ivy all over especially scalp. Every finger tip had horrible hang nails and was tired all day, and felt like a bitch. Everything bothered me and all I wanted to do was sleep all day with no appetite and not even a little thought of pussy. don't think jlo giving me a bj would've gotten me hard. Felt like a extremly bitchy girl. Felt like I was dying fairly quick too. With high e i had EXTREME BLOAT, occasional gyno symptoms, some times horny sometimes not even close and sometimes some lethargy. Felt like an emotional less bitchy girl. Would rather have high e than low e IMHO. High and low had 3 things in common. took forever to bust , small load and lethargy. Found my sweet spot taking 12.5mgs liqui aromasin every 12 hrs. Still had back pain but highly bearable compared to dirt low e occasional dryskin but rock hard boners and felt like THE man. Tried a lot of diff dosing protocols and ime this was the best. Bad thing was found my sweet spot with 3weeks left on cycle 
hope I wasn't the only one that went through this drastic rollercoaster
and felt like THE man. Tried a lot of diff dosing protocols and ime this was the best. Bad thing was found my sweet spot with 3weeks left on cycle hope I wasn't the only one that went through this drastic rollercoasterforeveryoung
New Member
something about your post is confusing
first you say on 12.5mg of aromasin every day you felt bad and you think that was because of low e2
then you say on 12.5mg of aromasin every 12 hours you found your sweet spot and felt like "the man"
first you say on 12.5mg of aromasin every day you felt bad and you think that was because of low e2
then you say on 12.5mg of aromasin every 12 hours you found your sweet spot and felt like "the man"
Said FIRST 2 WEEKS of test e was taking such a high dose when my test levels weren't sky high compared to my last 3weeks when I was doing double the ai dose and my test levels were through the roof. So im obviously going to feel the ai more when my e levels aren't as high the first 2 weeks compared to my last 3 weeks.
I'm on TRT for only a year, and in my limited experience, this has been the complete opposite for me. When my E2 is low, I am hornier, and my erections are more sensitive and my orgasms are more intense. Maybe my age - I'm 65. I'm on Androgel 1.62% - 3 pumps a day, sometimes 4. hCG at 250iu EOD, sometimes ED depending on my mood. And take 0.25 anastrozole every 3 or 4 days - depending on what my body is telling me.
Side question: If I stop the a.i. will my body normalize itself? Or will I need it for as long as I'm TRT - for life?
I've been told that I'm an "E converter" - aromatize easily and I have found that I'm also VERY sensitive to ai's. (When on test cyp, I had to go to sleep when dosed .5mg of anstrozole E3D. Had no idea that it was the ai until months later.) I'm of normal weight - a former long distance runner - and in the shape of a man 20 years younger.
So I guess that proves that everyone is different.
E-2 causing sensitive feelings of love, erections, being horny?
I think your confusing the function of E-2 with TT.
Jim
I think your confusing the function of E-2 with TT.
Jim
lanier1974
New Member
Jim, by all means please help all of us sort this out. All I know is, more AI, to a point, better erections, very low sensitivity both emotionally and in my penis. Less AI, to a point, the opposite.
I'm still running my spreadsheet morning wood experiment. Ill post when I have enough (admittedly subjective) data. Take it for what it's worth.
Lately, I've been doing 12.5mg E3D for two weeks, two days off in between doses, and MW has been low. I skipped my dose yesterday. So im 3 full days no dose. This morning for hours I got my first strong, long lasting, reoccurring MW in a week or two. Yesterday afternoon, when I should have had my morning dose but didnt, I was eyeballing girls on the train to bend over that I'd never consider. NOTHING else has changed. My workout and diet are tracked carefully.
Now, wtf do YOU think the reason for this is? According to what happened, my free T should be decreasing, and my E increasing. So why the increase in horniness AND morning wood?
foreveryoung
New Member
isn't "feelings of love" shown to have more relation to oxytocin than tt or e2? and maybe even prolactin and dopamine/serotonin? I have to refresh my memory on this though, been awhile since I read much about it, I seem to remember something about the dopamine agonists affecting need for emotional bonding too.
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Have to say when I dropped the AI sensitivity in peepee went way up. Since I doubled my dose of T I just want to bang the crap out everything.
Not sure about the feeling of love....I mean if you call love wanting to bend even unattractive chicks over....then yeah sure....increased feelings of love
lanier1974
New Member
Love/lust/emotional bonding, whatever. I just meet mental feelings (which are different for everyone), vs sensitivity in the nether regions, and harness.
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