MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
I would classify that as a win. Especially the loss of the hiccups.
15MG was hell, I was getting them daily, for hours at a time. Literally wanted to kill myself but someone kept me around
Have you trialled using digestive enzymes before meals? Actually helped a great deal for me on Reta. That is if the symptoms ever come back.
Ghoul
Well-known Member
That's what happens as you approach the weight "set point" for that dose. The "maintenance dose", where weight remains stable and you feel no sides. If your weight increases, the old effects will return to push you back down.
I've been on sema for 2 weeks now and have excellent appetite suppression at 0.25mg. I plan on staying at this dose until I feel appetite suppression decreasing. With a half-life of 1 week, my theoretical dosage would still increase with a weekly dose as written below:
Week 1: 0.25mg
Week 2: 0.125 + 0.25 = 0.375mg
Week 3: 0.25 + 0.1875 = 0.4375mg
Week 4: 0.25 + 0.21875 = 0.46875mg
At the end of week 1 I noticed a negligible increase in appetite suppression, but nothing that made it difficult to stay within my calorie deficit. Is it a bad idea to just wait until my theoretical blood level comes back down to ~0.125mg vs just dosing every week? I don't really see why I need higher blood levels if what I'm on already is working well. If I wait then I could dose as follows:
Target 0.125mg @ 0.25mg every ~10.5 days
I'm not doing this for cost purposes. I just want to minimize tolerance buildup. Curious if anyone else has spaced out longer than 1 week?
Week 1: 0.25mg
Week 2: 0.125 + 0.25 = 0.375mg
Week 3: 0.25 + 0.1875 = 0.4375mg
Week 4: 0.25 + 0.21875 = 0.46875mg
At the end of week 1 I noticed a negligible increase in appetite suppression, but nothing that made it difficult to stay within my calorie deficit. Is it a bad idea to just wait until my theoretical blood level comes back down to ~0.125mg vs just dosing every week? I don't really see why I need higher blood levels if what I'm on already is working well. If I wait then I could dose as follows:
Target 0.125mg @ 0.25mg every ~10.5 days
I'm not doing this for cost purposes. I just want to minimize tolerance buildup. Curious if anyone else has spaced out longer than 1 week?
IronMetal_2
Member
Read up on how these drugs work. There is no tolerance per se.
These drugs will basically lower your "Weight" Set-Point. The higher the dose (up to a limit ofc), the lower the set-point. The appetite suppressing effects will become lower once you reach your new set point for the specific dosage you take. Once your weight reaches the set-point, you will literally not feel a damn thing from the drug (and that's good).
Stick with the official protocol and just pin once a week if you intend to reap the benefits of these drugs long term.
@Ghoul can you finally do a 101 sticky post with common questions and answers
I always thought weight set point was bogus?
IronMetal_2
Member
It's certainly not bogus for these drugs.
You can debate weight set point in general, but that's just how these drugs work. It's also a good analogy. We keep reading about people talking about tolerance when there simply is no tolerance.
You'll notice this as well when you use them for longer time.
I don't believe in weight set point theory, so I will do some research. I know receptors can up and down regulate with prolonged exposure to agonists/antagonists, but I don't know about GLP1 receptors specifically.
Another paper detailing health protective effects of the GLP-1 RA drugs.
Popular diabetes and obesity drugs also protect kidneys, study shows
Ghoul
Well-known Member
A lot of people assume these benefits are somehow related to weight loss because so many study subjects are overweight, but they go far beyond what could attributed to weight loss. Everywhere there are GLP receptors, which includes every organ, being activated, something good seems to happen. From blood vessels to nerves to the brain.
Researchers have been noticing this in petri dishes with human tissue exposed to GLP for 30 years.
We're going to see a widening divide between those spared from most common chronic diseases because they're using GLPs and those who aren't.
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