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Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Here2Learn
Member
Came across this and thought it was kind of cool so wanted to share. Plots out your dose and half life to see how long it stays in your system. Was really interesting to plot T and R and see how much longer R stays in your system. Just a nice visual.
glp1plotter.com
GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator
Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.
glp1plotter.com
Ghoul
Well-known Member
Just a PSA about this calculator from our friends on Reddit. Semaglutide induces drug neutralizing immunogenicity. Once a week dosing kept this immunity from developing beyond a minor level.
"immunogenicity increases with more frequent dosing".
When 95%+ of pharma protocol Sema and Tirz users achieve significant, durable weight loss with no loss in effectiveness for years, but the Reddit scientists find every compound "stops working" and they end up stacking Sema/Tirz and Reta, using daily micro dosing, yet 300 injections later can't seem to lose the 10 pounds they've been trying to for the last year, consider this may be the problem.
"immunogenicity increases with more frequent dosing".
When 95%+ of pharma protocol Sema and Tirz users achieve significant, durable weight loss with no loss in effectiveness for years, but the Reddit scientists find every compound "stops working" and they end up stacking Sema/Tirz and Reta, using daily micro dosing, yet 300 injections later can't seem to lose the 10 pounds they've been trying to for the last year, consider this may be the problem.
Here2Learn
Member
I was not thinking about the micro dosing part of it, it was how each one stays in your system so differently. Just a visual for half life and how they build in your system.
Edited to add NOT thinking about
Last edited:
Ghoul
Well-known Member
Not a dig at you at all, the more info the better we can make our own choices. I'm actually ok with volunteer guinea pigs, merely pointing out that just because the developers of these drugs can fit the instructions for use in two sentences on the box of pens, doesn't mean they weren't developed by carefully evaluating hundreds of factors over the course of years, immunogenicity being one of the big ones.
99% of users don't even think the ratio of BAC water to dose makes any difference, and choose based on whatever's convenient. #pharmacokinetics #aggregation
Are we looking at the same plotter? Cuz R and T don't have much of a difference in how long they stay in your system, just tirz has a little shorter halflife.
Sema has the longest
Sema has the longest
Came across this and thought it was kind of cool so wanted to share. Plots out your dose and half life to see how long it stays in your system. Was really interesting to plot T and R and see how much longer R stays in your system. Just a nice visual.
GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator
Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.
Here2Learn
Member
I was comparing .75mg R and 4mg Tirz so I guess my comment came from how much slower the .75 was being absorbed vs the 4mg Tirz. Sorry I should have stated that and it only affects me personally so probably shouldn’t have said that at all. Lol
Here2Learn
Member
My post should say I was NOT thinking about the micro dosing part. Forgot the not.
IronMetal_2
Member
While I agree, I think the most important factor why they chose the 7 day injection frequency is mere convenience.
That's not to say that I would recommend doing more frequent injections, quite the contrary actually. But I don't think there is harm in doing a bit less, like 5 days with Tirzepatide...
That's not to say that I would recommend doing more frequent injections, quite the contrary actually. But I don't think there is harm in doing a bit less, like 5 days with Tirzepatide...
Ghoul
Well-known Member
I'm sure that was a factor. But that's where we know, with certainty, immunogenicity is not a problem. Had they conducted testing using a 5 day dosing schedule, perhaps 5% or 10% would've developed a problematic level of immunogenicity though. We just don't know, because that's not what was measured,
If the company said "let's offer a 5 day dosing frequency option in the directions", because it's a protein based drug, the FDA would forbid that until it was proven immunogenicity wasn't a problem at that frequency.
So then the question becomes, why take the risk, however small it may be perceived? Not losing weight fast enough? How impatient can someone be?
Agree completely and actually I liked on both sema or Tirz (more in tirz) that the last two days before the injection I felt hunger coming back or a less slowing of gastric emptiness. It was refreshing.
Ppl that have a problem with that should work on their psyche
Ghoul
Well-known Member
The risk for us using this unregulated stuff is actually far higher because they're hardly the "clean" peptides pharma used in their trials. I have little doubt in a few years, we'll read case reports of people who've developed immunity to natural GLP and GIP, and suffer serious metabolic problems, like taking an "anti-GLP".
All the more reason to reduce risk by minimizing frequency of exposure.
Here2Learn
Member
I like that feeling too, couple days before I don’t feel the effects at all but gives me a couple days to feel where I’m really at. I look forward to them.
Tirzepatide Immunogenicity on Pharmacokinetics, Efficacy, and Safety: Analysis of Data From Phase 3 Studies - PMC
Antidrug antibodies (ADA) can potentially affect drug pharmacokinetics, safety, and efficacy. This work aimed to evaluate treatment-emergent (TE) ADA in tirzepatide (TZP)-treated participants across 7 phase 3 trials and their potential effect on ...
pmc.ncbi.nlm.nih.gov
Ghoul
Well-known Member
It's the immune system's reaction to peptides. An immunogenic reaction creates antibodies that neutralize the drug, making you immune to it, so the drug becomes less, or even completely ineffective.
It's what a vaccine does intentionally, but
in this case unwanted and major area of concern for pharma and the FDA,
Another possibility with peptides that mimic hormones, like GLPs, is developing a cross immunity to the natural hormone, which can be extremely serious,
It can't always be avoided, but minimized by controlling factors like frequency of dose administration, using the correct ratio of water / peptide reconstitution, and preventing the peptide from degrading, which all contribute to worsening immunogenicity risk.
View: https://youtu.be/NCJmoPfOZlI
Needs to get some sema going.
I love it that they say he tried to escape the diet and fitness clinic but failed when he got stuck inside a shoe rack.
Lol.
Crumbs, you are so awesome.
Have a good Sunday everyone.
(P.s. sorry, couldn't help it. He had be featured on Meso, lol).
View: https://www.instagram.com/reel/C_litnxvC25/?utm_source=ig_web_copy_link
I love it that they say he tried to escape the diet and fitness clinic but failed when he got stuck inside a shoe rack.
Lol.
Crumbs, you are so awesome.
Have a good Sunday everyone.
(P.s. sorry, couldn't help it. He had be featured on Meso, lol).
View: https://www.instagram.com/reel/C_litnxvC25/?utm_source=ig_web_copy_link
Ghoul
Well-known Member
Won't help domesticated dogs lose weight apparently, but would work on cats.
No way.
For real, they give it to cats?
Lol, first world pet care.
This is funny.
We need to send some to Crumbs.
He hates the threadmill and the pool.
Bless him.
Thanks
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