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Side effects vary a lot. I get no fatigue even at 15mg a week.I've observed users complaining about fatigue with Tirz but when they add Reta it reverses and energises them.
Is anyone else experiencing this? Is there anything else to prevent the fatigue with Tirz?
Side effects vary a lot. I get no fatigue even at 15mg a week.
Only sides I get from Sems and Tirz is indigestion. I take famotidine with them. No gastric slow down. No cramps. No other common sides as long as I increase dose appropriately. On the other end of the spectrum some people have their GI tract ruined by Sema.
You ask a lot of questions that see like you are trying to figure out how you will react to these but no one can answer that for you. Pick one, start low and titrate slowly. Take notes on the dosages, changes, positives and negatives and then you will know. If you start at recommended doing you will be fine. If you don't like it then just stop.
Side effects vary a lot. I get no fatigue even at 15mg a week.
Only sides I get from Sems and Tirz is indigestion. I take famotidine with them. No gastric slow down. No cramps. No other common sides as long as I increase dose appropriately. On the other end of the spectrum some people have their GI tract ruined by Sema.
You ask a lot of questions that see like you are trying to figure out how you will react to these but no one can answer that for you. Pick one, start low and titrate slowly. Take notes on the dosages, changes, positives and negatives and then you will know. If you start at recommended doing you will be fine. If you don't like it then just stop.
I personally am on 0.5mg Semaglutide and I have been for the last 8 months. I have no side effects apart from anhedonia, lower libido and occasionally my food noise returns by 10%.
I am hoping replacing Sema with 2.5mg Tirz OR 1mg Reta per week will improve upon that without giving me any additional sides.
I am concerned about GIP functions in fat cells to increase fat accrual.
Maybe I shouldn't be because all research indicates health is improved. I am also wondering how this will affect body composition over the long term.
Yesterday was my first dose of 2.5mg Tirz.
I chose Tirz as I believe it has a superior food noise reduction to Reta and doesn't increase RHR as much. I will be watching the research over the next few years.
There is ZERO evidence of Tirz increasing fat accrual. Tens of millions of patients using this compound for years. What do you think the odds are of no one, patients doctors, researchers noticing increased fat mass? Come on...
Nothing to worry about. For the overwhelming majority, Tirz shows greater weight loss, better body recomposition, and fewer sides.
Thank you, hopefully my experience will be good and I will report back.
Why do you think there is a GLP1 agonist coming out with a GIP antagonist component? This is the opposite to how tirz works. What do you think this change will achieve?
Also why do you think Eli Lilly reduced the GIP component in Reta vs their previous medication Tirz?
Goddamn Obama!Eli ran out of room on the peptide chain to include more of a GIP component. Not chemically, legally.
Sema is 31 amino acids. Tirz 39. Reta 39.
TLDR: an obscure part of Obamacare allows peptides over 40 amino acids to be copied by competitors almost immediately.
As a result, nearly all new peptide/protein drug development projects have been focused on sub 40 amino acid peptides, even when larger chains would make the drug better.
Goddamn Obama!
Eli ran out of room on the peptide chain to include more of a GIP component. Not chemically, legally.
Sema is 31 amino acids. Tirz 39. Reta 39.
TLDR: an obscure part of Obamacare allows peptides over 40 amino acids to be copied by competitors almost immediately.
As a result, nearly all new peptide/protein drug development projects have been focused on sub 40 amino acid peptides, even when larger chains would make the drug better.
I personally am on 0.5mg Semaglutide and I have been for the last 8 months. I have no side effects apart from anhedonia, lower libido and occasionally my food noise returns by 10%.
I am hoping replacing Sema with 2.5mg Tirz OR 1mg Reta per week will improve upon that without giving me any additional sides.
I am concerned about GIP functions in fat cells to increase fat accrual.
Maybe I shouldn't be because all research indicates health is improved. I am also wondering how this will affect body composition over the long term.
Yesterday was my first dose of 2.5mg Tirz.
I chose Tirz as I believe it has a superior food noise reduction to Reta and doesn't increase RHR as much. I will be watching the research over the next few years.
We always have to keep in mind despite the long track record of humans using this
Seperate animal studies showed that Tirz increased the expression of certain genes in Brown Adipose Tissue, boosting thermogenesis, ie, the ability of brown fat to oxidize fats to keep internal organs warm. It's been observed "naturally thin" and underweight people have greater Brown Adipose Tissue mass that's also more reactive than normal and overweight subjects.
Here's the killer part of this, if it holds up in future research. The effect is CUMULATIVE. The longer one is treated with Tirz, the greater the increase in thermogenic capability becomes.
Thank you. I always love your informative posts.
Is that why Tirz users complain about being cold? Do you think this effect will work on tiny dosages?
"Ruin" I don't mean permanent. I mean bad enough GI sides that they can't take it.Ok we need to straighten a few things out here.
With extraordinarily rare exceptions, Tirz has fewer side effects than Sema.
That's not up for debate, every clinician prescribing these drugs know this.
And "ruined GI tracts" from Sema is a load of bullshit emanating from some reddit hypochondriacs.
Things that don't happen:
Docs to tens of milllions of diabetics and overweight patients: "Here's your prescription for Ozempic/Wegovy. It's very effective, but it may ruin your GI tract.".
"Ruin" I don't mean permanent. I mean bad enough GI sides that they can't take it.
I’ve found as long as my diet is lower in fat I don’t get the nausea. I’ve wondered if GLPs may end teaching people how to eat long term since you and up eating pretty clean to avoid side effects.Oh yes for sure. Brutal GI sides are entirely possible, especially with Sema. I think they can be avoided by being very careful not to eat "beyond your hunger", especially when starting or increasing the dose. In my experience, the physical limitations on food intake, and the "punishment" (nausea, acid reflux) for eating too much, come before the appetite suppression. kicks in. zap you've got to anticipate it and eat just until appetite is satisfied and stop. Wait at least another hour before eating again. Staying. hydrated, and a glass of Metamucil fiber daily can help a lot.
The latest guidance tells doctors to be vigilant for the worst sides from week 4 to 8 for Sema, and week 2 to 4 for Tirz.
That said, quite a few folks have been hospitalized after taking 20x the intended dose, 5mg instead of .25mg and while very uncomfortable, they always recover in a few days without permanent damage.
Sorry to interject here, but out of curiosity WTF is "food noise"?I personally am on 0.5mg Semaglutide and I have been for the last 8 months. I have no side effects apart from anhedonia, lower libido and occasionally my food noise returns by 10%.
I am hoping replacing Sema with 2.5mg Tirz OR 1mg Reta per week will improve upon that without giving me any additional sides.
I am concerned about GIP functions in fat cells to increase fat accrual.
Maybe I shouldn't be because all research indicates health is improved. I am also wondering how this will affect body composition over the long term.
Yesterday was my first dose of 2.5mg Tirz.
I chose Tirz as I believe it has a superior food noise reduction to Reta and doesn't increase RHR as much. I will be watching the research over the next few years.
I’ve found as long as my diet is lower in fat I don’t get the nausea. I’ve wondered if GLPs may end teaching people how to eat long term since you and up eating pretty clean to avoid side effects.
Sorry to interject here, but out of curiosity WTF is "food noise"?
Sorry to interject here, but out of curiosity WTF is "food noise"?
Food noise is a colloquial term. It refers “to the constant thoughts or recurring ruminations about food which could contribute to overeating
@Ghoul
Have you noticed heavier people need higher dosages of these drugs?
“Body weight was the most important covariate for Semaglutide exposure, showing decreased exposure with increasing body weight.”