MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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Good question… cysts on the liver for sure is what they said… thick fat lipoma’s id suppose all over other areas… noticeable as well
Thats why im hesitant to start gh… but perhaps tirz will help reduce them? Perhaps
Ghoul
Well-known Member
I'm not following. Which do you have? Cysts on your liver, or lipoma on the body, or both?
Ghoul
Well-known Member
Ok, I had fatty liver disease (like most adults today), and lipoma in various places that seemed to increase in number and size over the years. I noticed the first in my late teens.
Liver cysts and lipoma both have unknown causes, but are considered genetic.
Lipoma are benign(but can be painful), made up of a fat cells that, due to some unknown trigger, begin cloning themselves and form open or encapsulated tumors.
Both conditions are associated with high triglycerides, another condition mostly attributable to genetics.
I actually had a couple of "angiolipoma" in my back, where mutated blood vessels grow inside them, containing tiny sections of artery, capillaries, and veins, that go nowhere. They can get embolisms and become painful. I had them removed (after having to educate idiot doctors who insist "lipoma can't cause pain"), and it resolved all my longstanding lower back pain. Even the skeptical plastic surgeon (a better option for aesthetic results), who was happy to do the job, couldn't believe what he saw after the operation "No wonder that was causing you pain", and that's when I found out they were angiolipoma, not just lipoma.
Anyway, lipoma are known to enlarge with weight gain, but don't shrink with weight loss.
Mine weren't visible, but I could feel them.
Your post reminded me of something that happened within a year of starting GLPs. The lipoma disappeared. All of them. I literally just felt the spots on my thighs where they had been my entire life, and they're still gone.
The reversal of fatty liver disease is now an understood benefit of these meds, mine went from Stage one to zero. Similar to the my observation of the anti-addiction. behavior effects of GLPs long before it was formally written about by researchers, I'm pretty sure an anti-lipoma effect will be recognized sooner or later.
Which will be great news, since there's no cure, and many people have severe, disfiguring forms of the condition. I know some have had surgery to remove
dozens at a time.
Thanks! Yeah im hoping tirz helps alleviate them and stops the pain, these are painful, and i do not have high triglycerides… just high ldl, or 177 and total cholesterol of like 250, cant bring it down no matter what i try…
iris
Well-known Member
If you were to stop taking tirz, would the lipoma and liver condition come back, even with a controlled diet?
And no, no judgement here.
Just curiosity, if it is something genetic
Ghoul
Well-known Member
I think there's a great chance you'll see significant improvement. I switched from Sema to Tirz specifically for the liver health benefits.
I read something today that is looking at micro dosing sema, so we shall see if that works… i need to start super low below their recommended dosages because im sensitive to meds…
Well whats odd with mine is i never had these until i went thru basic training… and after i had been around chemicals ffor an extended amount of time
Ghoul
Well-known Member
So only judgement if it isn't genetic, lol? It is genetic, tends to run in families, but it's not terribly uncommon either. Many people have a lipoma or two that are never troublesome.
The answer is I don't know if they'd come back. That would presume they're still there, in some shrunken form. I've read that the mutant fat cell "seeds" for lipoma are present from birth, waiting on some trigger, theorized to be hormonal, to start replicating. They're more common in women.
Gaining weight causes them to grow, like normal fat would in a calorie surplus, but these mutant fat cells don't release energy the way normal fat does.
So lipoma growth is a one way street,
Now I'll go in my completely unqualified layman's theory as to why they may have disappeared from every part of my body where they were present (both thighs, both forearms, bilateral which is common, and a few others on my back and upper abdomen. Again, not visible, thankfully. but they could be felt as rubbery masses under the skin).
There's a Tirz induced effect that's independent of weight loss.
Constant GIP activation promotes hydrolysis of triglycerides stored in fat cells, making them more easily metabolize into fatty acids to be used as fuel.
Again, lipoma are made of mutant fat cells that grow in size from energy storage, but don't *release* energy through metabolic processes like normal fat.
I think continuous GIP agonism from Tirz may "break open" a metabolic pathway that allows the stored energy in lipomatous fat cells to release energy, and during a period of weight loss, they shrink like normal fat would, eventually disappearing.
Ghoul
Well-known Member
Mine appeared in the military too, but that age is common for them to be first noticed, and in line with the hormone trigger theory.
Thats super odd no? That they would appear during service… after having been injected with….?? And around chemicals…
iris
Well-known Member
Thanks @Avies48
@Ghoul thank you, too.
No, I did not want you to think mentioning the food part was aiming at anything in particular. I just didn't know if it was related to diet or genetic.
Even my mum's dog got a flipping lipoma, lol.
I know fatty liver can be down to alcohol consumption, though.
They say that is not reversible but idk if it is true.
@Ghoul thank you, too.
No, I did not want you to think mentioning the food part was aiming at anything in particular. I just didn't know if it was related to diet or genetic.
Even my mum's dog got a flipping lipoma, lol.
I know fatty liver can be down to alcohol consumption, though.
They say that is not reversible but idk if it is true.
Ghoul
Well-known Member
That thought crossed my mind, but lipid issues run in my family, and after spending time in the online lipoma "community", since most doctors are fucking useless for people with painful lipoma, late teens early twenties is when most people first notice
them.
Some injuries may cause them as well, and it's possible the physical strains of basic training may induce them. With all our advanced science, they're still largely a mystery. Mainly because they aren't considered harmful, few resources are directed toward the condition.
I tell people the response to their complaints of pain being dismissed with "Lipoma can't be painful" is to ask, "What if it's an angiolipoma?" (clinically proven to be sources of diffuse pain, only discernible through biopsy). 99% of general practitioners have never heard of an angiolipoma, and that comment often gets you the desired referral to a surgeon for removal, or a specialist for further evaluation.
Ghoul
Well-known Member
TLDR yes it can reverse fatty liver disease in alcoholics. but not cirrhosis. At least it halts progression of the damage.
Coincidentally, both Sema and Tirz are proving to be very effective cures for alcoholism (now called "alcohol use disorder"). Sema has one more round of clinical trials to be approved as a treatment for alcoholism.
In fact, the compounds appear to be "vaccines" against many types of substance abuse and other forms of compulsive behavior.
Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population - Nature Communications
Anecdotal reports from patients prescribed semaglutide describe a reduced desire to drink. Here, the authors show that semaglutide is associated with a 50%-56% reduced risk for both the incidence and recurrence of alcohol use disorder in real-world populations.
www.nature.com
UncleBuns
Well-known Member
Having excess visceral fat is very bad for your health.
Where you hold your fat on your body, whether it's visceral or where you hold subcutaneous fat is genetically determined. I imagine that there is also genetic variance in what fat stores are more easily depleted, but the bigger factor is probably where you hold the most fat. So wherever you have the most fat on your body will be the last to go just because there's more of it to get through.
Generally speaking, when you're losing fat, you will see reductions in all areas of your body at the same time, but it may not appear to happen that way because some areas have much more fat to get rid of so those areas will just take longer and the loss may not be as noticeable to the eye.
Just to throw out random numbers. If your butt has 2 lb of fat and your abdomen has 5 lb of fat and they're losing at about the same rate, you may think that you're losing fat faster from your butt because the changes in the mirror will be much more noticeable in a shorter span of time, even if you are losing at the same rate from both areas. Visceral fat is obviously not going to be noticeable unless you are doing dexa scans.
Ghoul
Well-known Member
I'd attribute this to an early side effect from the sudden drop in calories. It's not persistent. Whether / how Reta doesn't do this I don't know, other than perhaps it's because Reta is a rarely the first GLP class drug used, and users are already beyond that issue and accustomed to lower caloric intake by the point they switch to Reta.
iris
Well-known Member
How are you?
Hope you aren't out of diet coke.
Every time I see one now, it makes me think of you.
And also Donald Trump, lol.
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