MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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Juiced_lizard
Member
There is a big debate on if you should store in a fridge, room temp or a cryo freezer…..which @Ghoul will be here soon and post it I’m sure. It is best. In my opinion (now I don’t have 15 years of peptides sitting around) a year or 2 worth of peptides sitting in your dresser will be just fine.
Ghoul
Member
Peptides are as broad a category as food.
Is it ok to store food at room temp?
Salt? Coffee? Dried cereal? Sure.
How about fresh fish?
Some peptides are stable at room temp for a long time. Some degrade very quickly at room temperature.
ALL of them degrade less quickly in the refrigerator. Colder=better.
The only controversy is freezing, because both freezing and thawing induce damage, and whether a household freezer with its significant shifts in temperature may do more harm than good is in question. Just like salt water doesn't freeze a 0c, peptides don't freeze at the same temperature as water, its lower,
Every commercial peptide producer recommends -80c or lower for long term storage. At that temp there's no chance slight fluctuations in temperature could freeze/thaw the peptide repeatedly, damaging it.
TLDR: Refrigeration may not be necessary for every peptide, but it doesn't hurt, and is critical for some. Without knowing for sure, keeping it cold is the safer way to store peptides.
Anat
Member
Well, it’s been one wild week since I upped my Tirz dose from 5mg to 7.5mg. My appetite has clearly taken a vacation - I’ve been scraping together just 800-900 calories a day for the past five days, and I lost 4.5lbs (most likely just water weight). I’ve also been battling a slight fever and fatigue, and I’ve even had to practically force chicken down my throat just to hit a measly 120g of protein. Sounds miserable, right? But oddly enough, I’m kind of enjoying this lean, mean state of being. I’ll see how things shake out over the next three weeks before deciding whether to stick with this dose, ramp it up, or dial it back. The silver lining? My next cutting phase is going to be a breeze compared to those brutal ones without Glp-1.
Your next cut could be not much different from the one you know because the appetite suppression will fade and the only thing that will remain is that you will have less crave for cheat meals etc..but if you go on a strict cut you'll feel the "hunger".
So sure it will be easier but not that much easier as it would be right now.
I understand completely tho what you say about enjoying this state of not being hungry. I enjoyed it a lot when I first tried in the past semaglutide or Tirzepatide.
It's awesome to spend a whole day without thinking once about eating and to eat just a bit and feel satiated. It's not good for gains but it's so good for your mind and body too.
That's not true, my wife is bulking and the same dosage is giving her less and less of an appetite suppression.
When I was using semaglutide after a while at the same weight or heavier at the same dosage of 1mg I could eat anything I wanted.
This is one thing I gotta disagree Ghoul, especially because I have seen it firsthand
Juiced_lizard
Member
Swirl it around in your hands a little gently. Back and forth in your palms. How long has it sat? I just let mine sit for 10-15 mins and it’s normally fine without doing anything.
ok thanks. I litterally just put the water in 2 minuetes ago, the vial was also very cloudy.
Ghoul
Member
I'm not doubting you see it, but it's not how Sema and Tirz work. If it was, the 10,000+ subjects in the extended clinical trials taking the same stable dose for 3-4 years would see it lose effectiveness over time.
But that doesn't happen, with 100% certainty,
Something else is causing it if that's going on, and it's probobly related to immunogenicity and a steadily building immunity to the compound and loss of effectiveness that doesn't happen with pharma.
Exenatide, an earlier GLP drug, has this issue, with immunogenicity building over the course of 6 months to a year in some, losing effectiveness and diabetics having to return to insulin for blood sugar control,
And I hate to say it, but from my own observation, once a loss of effectiveness to GLPs develops, it seems to "stick", either being long lasting or possibly permanent, though it's too early to say. That's why I urge people to take it seriously and reduce the risk factors, including not jumping on and off, but at least staying on a minimum dose,
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I don't think the drug is stopping to work the glucose control is still there. The appetite suppression is not and that's because that's just a side effect and not why these drugs were designed.
It's like Viagra, they made it for BP and found I was shit for BP but great for bonerz.
Glp1 were made for diabetic then they saw it was great for fatloss. You still get all those benefits, glucose control and even great food control, meaning eating shit food is not appealing but the appetite suppression goes away with time at the same dosage, most of the ppl I know report the same effect, I mean I'm talking a large number of ppl not one or two.
Have you more muscle mass than you had when you were on the same dosage and about same weight?
Any change in activity or drug?
I'm not on the GLP-1 anymore since I started being followed by a coach because I couldn't eat enough food and didn't have the patience to wait for the effect to dissipate (I had just switched from sema to tirze and it killed my appetite at first)
when I was using it I had better glucose control by a mile, not sure about your question about muscle mass, can you reformulate?
Ghoul
Member
Good luck. Don't be disappointed if you don't feel the expected effects immediately. It takes a couple of weeks to build up stable blood levels and a lot of (mostly) men don't respond until higher doses. There are hyper-responders though, so starting low is prudent, since in rare cases it 2.5mg comes on very strong.
Well i tought glp1 had less hunger suppression on the same dose after a while for you.
Increased muscle mass and or activity with same body fat can make you more hungry. That is what I meant.
Ghoul
Member
They weren't designed for any particular effect any more than testosterone is designed for a particular purpose,
GLP and GIP are hormones that play a part in metabolic regulation, released after eating, these drugs are just adding to our natural levels, like TRT for metabolism. Bariatric surgery accomplishes the same thing, since stretching the stomach and intestines (ie, simulating being filled with food) triggers in an increase in the production of those hormones and their receptors.
The impact on appetite isn't a side effect, but part of the system that regulates energy intake. They just targeted diabetes first (already accustomed to daily injections). The big breakthrough was making GLP-1 last a week, like adding long eaters to testosterone,
You eat, nutrients in the intestine trigger GLP release, causing insulin sensitivity to increase so cells are prepped to absorb the incoming energy, blood glucose goes down as cells use it, and appetite is reduced, using the same mechanism that would kick in if you ate a huge meal (gastric slowing, psychological reduction in food appeal, etc) because you don't need more energy. As weight goes down, more GLP is required to suppress appetite since other mechanisms are stimulating appetite to get it back up to whatever your homeostasis level is,
They're not like diet pills that slowly lose effectiveness over time, though I know many people view them that way.
Even most general practioners prescribing these meds don't seem to understand how they work and aren't explaining things properly to their patients (ie, side effects will dissipate and you'll need to take this indefinitely to maintain the weight loss, because it's a chronic condition. Just like you don't stop blood pressure medication once blood pressure has gone down, stop insulin when glucose is controlled, or stop TRT because the man feels better). Apparently many stop taking GLPs after a while, not realizing 95%+ will regain the weight.
If New Obesity Medications Work, Why Do So Many Stop Them?
Recent research suggests that patients prescribed GLP-1s don’t fill their prescriptions or stop taking them. Yoni Freedhoff, MD, discusses the obstacles to patient adherence.
www.medscape.com
The advice from experts is that doctors should "sell" the other great health benefits other than weight loss to entice patients to keep taking it, Which is coincidentally my approach as well.
Just the reduction in systemic inflammation alone is worth taking them forever:
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