MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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Liter O' Test
Member
1mg tirz insulin sensitivity really falls off by day 4.
was going kinda hypo in the 60s in the first few days with a morning BG of 71 and this morning my FBG was 92 but sleep or stress mightve been a factor
doing 1.5mg now (bringing me to serum of just shy of 2mg 2nd shot levels) and doing 2mg next week, hoping to just ride that out as it seems to be a sweet spot if you arent seeking appetite supression
was going kinda hypo in the 60s in the first few days with a morning BG of 71 and this morning my FBG was 92 but sleep or stress mightve been a factor
doing 1.5mg now (bringing me to serum of just shy of 2mg 2nd shot levels) and doing 2mg next week, hoping to just ride that out as it seems to be a sweet spot if you arent seeking appetite supression
Yes, pretty much by the book. First six months I stayed at 2.5 and 5 mg, then every four weeks I bumped it up by 2.5 mg until I reached 15 mg. On some doses I stayed a bit longer than four weeks, but it was all good.
phenominal34
Banned
Try 5mgs 3 times a week. Thats where I’m at and feel great
Monday / Thrs / Sat
Skin irritation is only side I experience
Ghoul
Member
I suggest a gradual taper down. 10 would be reasonable and significantly reduce the risk of a repeat of bad sides, but avoid the appetite rebound that can be insanely strong. Then reassess whether to stay at that level or drop again.
You've invested a lot of time titrating up the proven way, maintaining steady levels with gradual dosage changes. You can maintain that steady course with a small adjustment for the unexpected sides, instead of overreacting and sending levels of insulin and satiety hormones crashing down, only to find yourself scrambling to raise the dose again after an over correction leads to a voracious appetite.
dinfar1337
New Member
drop down to 5mg. tirz has such a long half life it'll feel natural.
like ghoul says drop down however u like to what dosage you need. but u can absolutely drop down in 1 week
I would not pin for at least a week and then start over with a more reasonable dose
Ghoul
Member
He had titrated up to that dose and been on it for a while. 15mg is the most common maintainance dose.
Really? isn't it also the maximum dose?
dinfar1337
New Member
i feel like most people i run to is like me who needs 5mg or less
Liter O' Test
Member
are you running into formerly obese people IRL that have a doctors prescription and part of a study? or are you going off a small % of steroid users on the internet running it off label
dinfar1337
New Member
steroid users steroid users steroid users
The_Thinking_Elf
New Member
Big increases in pharma grade Mounjaro coming to the UK Sept 1st
People over here in the UK are not happy about this as the price is going up by 170%.
www.theguardian.com
People over here in the UK are not happy about this as the price is going up by 170%.
Eli Lilly ramps up UK price of weight loss jab Mounjaro after Trump demands
The US president had put pressure on the pharmaceutical industry to make drugs cheaper for Americans
Speaking of skin irritation anyone found a solution to this? I have rotated abdomen sides made sure everything is clean and dry, new Bac water etc and every time I get a giant spot and irritation. Nothing for the old lady with the same process.
Ghoul
Member
Right. The normal pharma protocol has you titrate up one dose level every four weeks, as tolerated, and either stop once goal weight is reached or max dose of 15mg.
bananafeet
Member
Interesting data:
Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity.
Source:
The novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes
American Diabetes Association – 81st Annual Scientific Sessions; Virtual; 25-29 June 2021
TLDR from this paper (see attached images):
Retatrutide compared to native ligands:
1.7x weaker at GLP1r agonism
2.5x weaker at GCCR agonism
7x STRONGER at GIPr agonism
This article shows that even tho it's weaker at the GCCR by 2.5x the glucose output from hepatocytes (liver cells) is only 0.6x weaker. So it's quite effective at burning liver fat directly or gluconeogenesis? I'm not sure.
These agonism numbers make it an "unbalanced ligand" or agonist. Compared to Mazdutide which is much more balanced in it's profile. I'm still to find the EC50 for Mazdutide.
See attached slides for reta. I've got a few more articles to read on it.
Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity.
Source:
The novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes
American Diabetes Association – 81st Annual Scientific Sessions; Virtual; 25-29 June 2021
TLDR from this paper (see attached images):
Retatrutide compared to native ligands:
1.7x weaker at GLP1r agonism
2.5x weaker at GCCR agonism
7x STRONGER at GIPr agonism
This article shows that even tho it's weaker at the GCCR by 2.5x the glucose output from hepatocytes (liver cells) is only 0.6x weaker. So it's quite effective at burning liver fat directly or gluconeogenesis? I'm not sure.
These agonism numbers make it an "unbalanced ligand" or agonist. Compared to Mazdutide which is much more balanced in it's profile. I'm still to find the EC50 for Mazdutide.
See attached slides for reta. I've got a few more articles to read on it.
SnowyMiami
Member
Have you tried upping your protein to 300g a day? I'm a former fat ass and that is the only thing that stopped the hunger. Lyle Macdonald has great stuff on diet.
SnowyMiami
Member
Real pharma GLP's are starting to appear in Turkey.Big increases in pharma grade Mounjaro coming to the UK Sept 1st
People over here in the UK are not happy about this as the price is going up by 170%.
Eli Lilly ramps up UK price of weight loss jab Mounjaro after Trump demands
The US president had put pressure on the pharmaceutical industry to make drugs cheaper for Americans
I sometimes did eat that much protein but now I try to keep it under 200g since I don't need any more than 150g relistically. That much protein will create a lot of ammonia and oxidative stress. Excessive protein intake also ages you faster and puts strain on your heart and kidneys. tbh I haven't found that eating more than 150-200g of protein satiates me much. just feels like a waste of money and health when vegetables, tubers, legumes and fat sources would be cheaper and healthier.
I did eat 300g+ of protein for some periods of time but now I understand it was just dumb and expensive for me. I felt fuller but still had cravings. I think that eating 150-200g max and having more fats and high fiber carbs is the smarter way to go
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