MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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The_Thinking_Elf
New Member
Do you (or anybody) have a link to the higher dose (20-25mg/week) clinical trials?
Anyone have Hidradenitis Suppurativa and seen an improvement?
I have this illness, and I've been taking tirzepatide for about 6 months now, and the flares have disappeared. Now I only have scars remaining.
It could be a coincidence, but I've been diagnosed with this for about 5 years now, and all that time I had some flares and an open wound, even if it was minimal at the low point of the flare. The only thing that I do or take differently is tirzepatide.
Now it's like I don't have anything; it's normal. My armpits are the most affected. I had other areas affected, but it wasn't much compared to my armpits.
I have this illness, and I've been taking tirzepatide for about 6 months now, and the flares have disappeared. Now I only have scars remaining.
It could be a coincidence, but I've been diagnosed with this for about 5 years now, and all that time I had some flares and an open wound, even if it was minimal at the low point of the flare. The only thing that I do or take differently is tirzepatide.
Now it's like I don't have anything; it's normal. My armpits are the most affected. I had other areas affected, but it wasn't much compared to my armpits.
Liter O' Test
Member
Titrated down to 2mg tirz, reducing by about 1mg weekly.
this week is my first week without tirz
i did this because i believed it was affecting my sleep / mood
yes i was also on tren for most of tirz but according to my watch i had a "stress" increase like 2 days after injection that continued for two more days then slowly went down over the course of the week , then rose again following my next tirz injection, even once the tren cleared.
im taking anadrol now and my stress levels are lower than when i was just on tirz, i attribute most of this to improved sleep. perhaps this is why people experience fatigue on tirz, from lower quality sleep. something something vagus nerve. I had the best sleep score ive ever had the day I was scheduled to take my tirz dosage (but didn't)
The anadrol really curbs my appetite at 50mg a day split a.m p.m. . Been using it approx 10 days.
Im at 2500kcal now and i think its easier to be this low calorie, on this dosage of anadrol, vs 2-4mg tirz.
there may be other factors involved but i am 4 days into my first week tirz free and i will see how my stress and sleep score improve (and from that, RHR)
this week is my first week without tirz
i did this because i believed it was affecting my sleep / mood
yes i was also on tren for most of tirz but according to my watch i had a "stress" increase like 2 days after injection that continued for two more days then slowly went down over the course of the week , then rose again following my next tirz injection, even once the tren cleared.
im taking anadrol now and my stress levels are lower than when i was just on tirz, i attribute most of this to improved sleep. perhaps this is why people experience fatigue on tirz, from lower quality sleep. something something vagus nerve. I had the best sleep score ive ever had the day I was scheduled to take my tirz dosage (but didn't)
The anadrol really curbs my appetite at 50mg a day split a.m p.m. . Been using it approx 10 days.
Im at 2500kcal now and i think its easier to be this low calorie, on this dosage of anadrol, vs 2-4mg tirz.
there may be other factors involved but i am 4 days into my first week tirz free and i will see how my stress and sleep score improve (and from that, RHR)
RobbySmith
New Member
The study is easy to find. You have to know someone to see the actual doses being studied because they're not public, cited anywhere I could find and simply described as "investigational tirzepatide doses #1 and #2."
Liter O' Test
Member
ok back on tirz but im tired AF today,
I was tired af during the months on tirz in a surplus
. Im not even on anything other than TRT now.
so maybe it was the tirz as i intially thought, my sleep score/stages were good even though I got 6 hours, and im still tired.
I think i'll switch to reta , has anyone seen anecdotes on switching to reta and having more energy?
I thought that it was just a calorie deficiet making all the fats say they were tired but i dont think its a coincidence im drained AF today and feel like I have brainfog the next day after a dose.
stopped the anadrol and appetite returned so here i am on the glp train again
hows the reta switch been @The Answ3r
I was tired af during the months on tirz in a surplus
. Im not even on anything other than TRT now.
so maybe it was the tirz as i intially thought, my sleep score/stages were good even though I got 6 hours, and im still tired.
I think i'll switch to reta , has anyone seen anecdotes on switching to reta and having more energy?
I thought that it was just a calorie deficiet making all the fats say they were tired but i dont think its a coincidence im drained AF today and feel like I have brainfog the next day after a dose.
stopped the anadrol and appetite returned so here i am on the glp train again
hows the reta switch been @The Answ3r
Athleticfreak
New Member
Ill say that thru experience with both there’s a big energy difference in Reta compared to Tirz.
ParquetPatquet
New Member
Yep, that's all you'll hear people talk about when they switch from tirzepatide to retatrutide : mote energy. One thing people like to complain about on reta : it has less appetite suppression than tirz. If appetite suppression is important to you, you might want to stick with tirzepatide
Liter O' Test
Member
Ive heard that too, but my first try with a GLP was like 1mg of reta and that had me looking at food funny even though I was deep in a Intermittent fasting keto death cut.
Liter O' Test
Member
also, reflecting back on these few months i think ive had a mix of the following two. I definitely feel different, not sure if its ALL bad, but definitely lacking some dopamine, but probably processing my emotions and life better. not sure. im just a little too flat though
1.
GLP-1RAs activate receptors in brain regions like the hypothalamus, nucleus tractus solitarius (NTS), and mesolimbic system, which regulate appetite but also influence dopamine signaling. This can dampen reward responses (e.g., reducing "food noise"), but it might extend to broader anhedonia or reduced motivation, manifesting as brain fog. For instance, by altering dopamine release, it could temporarily impair focus or cognitive processing, similar to how some antidepressants affect mental clarity during adjustment. Preliminary evidence suggests this neurotransmitter shift could influence cognitive function, though it's more often protective long-term.
2.
GLP-1 promotes neurogenesis and synaptic plasticity in areas like the hippocampus (key for memory and cognition), which is beneficial long-term. However, during the adjustment phase, this remodeling might disrupt established neural circuits, leading to short-term cognitive glitches perceived as fog. Animal studies show enhanced plasticity, but human reports vary
RobbySmith
New Member
"ok back on tirz but im tired AF today"
Stacking Tirz with Survo brought all the energy back for many people (along with modest hunger). Tirz + Survo = "Ghetto Reta"
Liter O' Test
Member
im swearing off GLPs, feeling smarter and happier everyday past the day i was schedule for a dose.
this has been noticed by people around me, both the heaviness post injection and better mood post tirz
hell , i think even a low dose of tirz was making me eat MORE because i just felt bad and my body was like "Eat youll feel better"
On 6 mg/week of reta now and honestly… smooth ride. Food noise is dead all day, but when it’s time to eat I can still smash my calories like a normal human. Huge upgrade.
No mood dips, no zombie energy like I had on tirz. Energy is actually solid. Only plot twist is the sweet cravings. Reta woke up my inner dessert demon. No idea why, but now Halo Top is officially a “performance food” in my macros. 360 calories per pint, science approved.
With GH in the mix it feels like even at maintenance, or with a lazy +200-300 calories, I’m getting tighter and cleaner. Zero regrets switching.
Only downside is grocery shopping now takes 20 minutes longer because I’m standing in front of chocolate and tiramisu negotiating with myself like it’s a hostage situation.
SmallTitsIRL
Member
Because the studies were done with 1 weekly injection, that's their theory.
TRT is also done once every 9 days, but we do it daily. Do what feels best for you, no one cares, unless they got nothing going with their lives.
Photon
Member
Pharma has always done once a week during trials. Same for Sema Tirz.
I would advice not to listen to "some", whoever that is.
10mg tirzepatide over 3x weekly shots - excellent appetite suppression without a single side effect that some here are talking about, no energy dips, but I take modafinil 50-100mg almost daily.
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