GLPs: Anti-Consumption agents, of far more than just food.

[Ghoul]

For those suffering from any condition related to excess consumption, or know someone who is, keep this in mind and consider pointing them in this direction, regardless of weight:

"Anti-consumption agents: Tirzepatide and semaglutide for treating obesity-related diseases and addictions, and improving life expectancy"

https://www.sciencedirect.com/science/article/pii/S0033062024001798

 

[Rakusa]

There’s a lot of interesting information here. I’ve noticed that ever since I started taking Tirz, the small pleasures in life - like food, entertainment, and gaming - don’t appeal to me as much anymore. Now I feel colder and more calculated. I’m not saying that’s all bad; in fact, it’s helped with business because I don’t get as emotional or worked up as I used to.

Has this helped you maybe find hobbies that don't rely on immediate reward? Like some delayed gratification or creative work? I think this might be a chance, maybe it sticks if you keep at it.

 

[clearheaded]

I don't think so.

Just as the long term clinical trials prove there's no such thing as GLP "tolerance" ever developing, there no reason to believe the "enjoyment" of substances returns to a pre-GLP level.

mmm not so fast, isn't there a nice dose schedule EXACTLY to build tolerance? if u build a tolerance its addictive or will cause SOME sort of change/rebound etc.. thats just a reality of all substances.

also PLENTY of people note HUGE amounts of hunger after stopping esp considering stomachs are shrunk..

we will know more in a few years once ozempic gets off patent and independent research is done on larger scale. also perhaps they like finding things wrong if means can sell a new "better" drug exclusively as newly patented.

I agree no free lunch.

I think it may come in the form of actually causing insulin sensitivity issues and or "wearing out" ones pancreas to hasten diabetes esp if someone get heavier later in life. ya I know they have studies saying it won't, but SO many drugs have said similar things. and being pre diabetic and very obese and getting to healthy weight is alot different than loosing 10 lbs to look better. very different risk ratio profiles(if ever study it in healthy people) oxy was PROVEN not to be addictive remember.

 

[29trt]

Trying to cure a diseased society filled with diseased people with current pharmaceutical tech is like trying to build a microprocessor with tools from the middle ages.

Sure some folks will get some relief and thats good but remember what we are talking about here... people that cannot stop eating either because of genetics(which we cannot change yet) or mental issues( which are not multi factorial not just hormon signaling or insulin resistance related)

 

[Anonymous35]

Reta did that to me with working out. Didn’t feel any sort of way towards working out when usually I’m getting psyched up. Then when I did work out it just felt weird. Only on 1mg Reta

Same didn’t do gym for 3 weeks
That didn’t miss me very much

 

[bigtom343]

I think that Sema and Triz will become accepted for off label treatment of SUD because it’s already been backdoored in for treatment of several major conditions (sleep apenea, cardiovascular disease, obesity).
Drug discovery is moving rapidly with AI and computational molecular modeling programs. I wrote a paper on them recently for my doctoral program.

Semaglutide was discovered/developed because they noticed that patients were loosing weight on Liragultide. This made it easier for Sema to get fast-tracked for approval for diabetes treatment which backdoored in the path for weightloss treatment since it was so obvious (and so on and so forth).
Huge dollars are being put towards discovery of new compounds modeled after these GLP-1 agonists, and the “risk” portion of the money is for compounds targeting SUD. Expect to see a ton of ads offering $1000
for overweight drug addicts to participate in a study (and $3000 for addicts diagnosed with diabetes!).

 

[aljowa]

What we need is the law to lift the artificial limit of 40 amino acids in new protein drugs, so pharma can make the GLP portion more potent. For Tirz to add GIP, and Reta to add GIP and Glucagon, GLP had to be weakened in order to make "room" to fit within that artificial limit.

Out of curiosity, do you have any links or suggested reading regarding this arbitrary amino acid limit affecting pharmaceutical patent protections? I tried to search online, but couldn't find anything. I'd love to find more information regarding this.

 

[Middus]

I think that Sema and Triz will become accepted for off label treatment of SUD because it’s already been backdoored in for treatment of several major conditions (sleep apenea, cardiovascular disease, obesity).
Drug discovery is moving rapidly with AI and computational molecular modeling programs. I wrote a paper on them recently for my doctoral program.

Semaglutide was discovered/developed because they noticed that patients were loosing weight on Liragultide. This made it easier for Sema to get fast-tracked for approval for diabetes treatment which backdoored in the path for weightloss treatment since it was so obvious (and so on and so forth).
Huge dollars are being put towards discovery of new compounds modeled after these GLP-1 agonists, and the “risk” portion of the money is for compounds targeting SUD. Expect to see a ton of ads offering $1000
for overweight drug addicts to participate in a study (and $3000 for addicts diagnosed with diabetes!).

There are better drugs for SUD. Sema can't even beat sweet tooth yet.