HGH 10IU Results

[malfeasance]

Yep, i edited, thought some people might think its way too harsh,

LOL! Stick to your guns. Insulin, too.

 

[malfeasance]

I made this post about using the serum IGF-I test: The Serum IGF-I Test: Its purpose and its weaknesses, proper use, variation, average responses

It's probably worth mentioning, if interested purely in muscle anabolism, 300mg of test could get you approx. this level of IGF-I (GH response) along with all its other benefits for hypertrophy. Short-term ~300mg (3mg/kg) weekly TE increased serum IGF-I (314 ± 24 ⇒ 421 ± 29 µg/L) yielding ↑21% vs. eugonadal men...

Was that post meant to go with that link? I went to read it, but . . .

 

[Juicedhead]

bro 10iu my igf-1 was 955. It was on godtropin. It really varies a lot from person to person. I perosnally think that running TUDCA with NAC and other liver support supps helps a lot. The healthier your liver the more igf you will convert.

 

[bcramp112]

It's a bit unusual that your GH response (serum IGF-I) peaked at 2 weeks and had settled by 6 weeks. Usually, on average, there is a continuous increase through 6 weeks. Though there could be some variation. I will make a post about using serum IGF-I tests for GH response vs. quality/legitimacy of rhGH solutions.

Men often see something like a 330 IGF-I (mean, and with considerable variation) on 2.85IU (for a 100kg b.w. person) daily for 6 weeks.

The serum IGF-I test cannot tell you the quality (potency, purity) of your rhGH. It's a measure of your GH response to the product.

I forgot to mention i’m using 1g of Metformin daily, would that be having a large effect?

 

[Country Club Hero]

The Genotropin and Cinnatropin pens definitely have that smell - no doubt - and I can barely smell anything anymore

Love that smell! Geno pens have it super strong

 

[Type-IIx]

I forgot to mention i’m using 1g of Metformin daily, would that be having a large effect?

Yes,, it has a significant effect. Metformin increases serum IGF-I in response to GH. There's some data on it (with IGF-I values and GH doses) in my post on hGH + Metformin.

 

[Juicedhead]

Love that smell! Geno pens have it super strong

Dude I love that smell

 

[bcramp112]

Yes,, it has a significant effect. Metformin increases serum IGF-I in response to GH. There's some data on it (with IGF-I values and GH doses) in my post on hGH + Metformin.

Right but I thought it significantly raised IGFBP significantly as well, which prevents IGF-1 from binding to insulin receptors thus negating it’s use.

 

[Type-IIx]

Right but I thought it significantly raised IGFBP significantly as well, which prevents IGF-1 from binding to insulin receptors thus negating it’s use.

Interesting, do you have any references that aren't in cancer cell lines?

 

[bcramp112]

Interesting, do you have any references that aren't in cancer cell lines?

Well I’ve only seen one that tested hGH’s effect on “Bovine Granulosa Cells” but I’ve seen other articles referencing metformin’s effect on IGFBP.
Do you think my IGF-1 might have been lower due to me fasting for 12 hours prior to the blood test?
My Hba1c went from 4.7-4.8 so there must be some significant effect occurring ...

 

[Type-IIx]

Well I’ve only seen one that tested hGH’s effect on “Bovine Granulosa Cells” but I’ve seen other articles referencing metformin’s effect on IGFBP.
Do you think my IGF-1 might have been lower due to me fasting for 12 hours prior to the blood test?
My Hba1c went from 4.7-4.8 so there must be some significant effect occurring ...

First, what was different about the conditions of testing in the first versus the second test? Were you fasted for both?

Certainly, GH has an indirect effect on HbA1c (it raises it) whereas IGF-I has an opposing effect on HbA1c (it lowers it). An increase in HbA1c may fairly be characterized as showing an increased hyperglycemia (GH-induced). HbA1c is a proxy measure of the glycosylated hemoglobin % and RBC turnover. All that matters is your A1C is healthy here.

The meaningfulness of Met's effects on IGFBPs and IGF-I serum levels is far from clear from the literature. Bovine granulosa cells do not function similarly enough to our healthy human cells, primarily skeletal muscle, et cetera; and besides, the interactions between IGF-I and its 6 binding proteins in some instances (i.e., in skeletal muscle) may increase its half-life and bioavailability. To confidently state that Met reduces IGF-I bioavailability (despite clearly augmenting serum IGF-I in response to rhGH treatment) with the current literature on the matter is a sure sign of a conman if you've heard that somewhere.

 

[bcramp112]

First, what was different about the conditions of testing in the first versus the second test? Were you fasted for both?

Certainly, GH has an indirect effect on HbA1c (it raises it) whereas IGF-I has an opposing effect on HbA1c (it lowers it). An increase in HbA1c may fairly be characterized as showing an increased hyperglycemia (GH-induced). HbA1c is a proxy measure of the glycosylated hemoglobin % and RBC turnover. All that matters is your A1C is healthy here.

The meaningfulness of Met's effects on IGFBPs and IGF-I serum levels is far from clear from the literature. Bovine granulosa cells do not function similarly enough to our healthy human cells, primarily skeletal muscle, et cetera; and besides, the interactions between IGF-I and its 6 binding proteins in some instances (i.e., in skeletal muscle) may increase its half-life and bioavailability. To confidently state that Met reduces IGF-I bioavailability (despite clearly augmenting serum IGF-I in response to rhGH treatment) with the current literature on the matter is a sure sign of a conman if you've heard that somewhere.

No I am actually on your side on this one, I have seen a lot more evidence supporting Metformin as working synergistically with hGH.

Keep in mind, for both tests, the last injection was all at once (10IU with 1ml bac water) 12 hours prior to the test (fasted for 12+ hours.)

After the vials are mixed I store them in the fridge for no more than14 days (all used by that time.) The unmixed ones are frozen.

So either, I might have not been eating enough, the hGH is crap (which is surprising since its dragon ordinance.) Or my liver just hardly secretes IGF-1 in response to high hGH doses..

 

[Type-IIx]

No I am actually on your side on this one, I have seen a lot more evidence supporting Metformin as working synergistically with hGH.

Keep in mind, for both tests, the last injection was all at once (10IU with 1ml bac water) 12 hours prior to the test (fasted for 12+ hours.)

After the vials are mixed I store them in the fridge for no more than14 days (all used by that time.) The unmixed ones are frozen.

So either, I might have not been eating enough, the hGH is crap (which is surprising since its dragon ordinance.) Or my liver just hardly secretes IGF-1 in response to high hGH doses..

!!! Don't freeze your GH!!!

With "generics," you don't even want to have them reconstituted for more than just a few days before use. Less time, the better. Keep them in the fridge, not the freezer.

I'm afraid freezing what you have may have damaged the peptide. To what extent is unknown. This is considerably less of a problem with pharmaceutical preparations, but very real with generics which usually lack antimicrobial and stabilizing preservative agents.

 

[bcramp112]

!!! Don't freeze your GH!!!

With "generics," you don't even want to have them reconstituted for more than just a few days before use. Less time, the better. Keep them in the fridge, not the freezer.

I'm afraid freezing what you have may have damaged the peptide. To what extent is unknown. This is considerably less of a problem with pharmaceutical preparations, but very real with generics which usually lack antimicrobial and stabilizing preservative agents.

You mean keep the powder form in the fridge?
Just to clarify, once it's liquid, it's in the fridge. When it's powder, it's in the freezer..

 

[malfeasance]

@Mighty-mouse keeps his at room temperature until reconstituted, and has had excellent results with lots of IGF-1 testing posted.

 

[malfeasance]

bro 10iu my igf-1 was 955. It was on godtropin. It really varies a lot from person to person. I perosnally think that running TUDCA with NAC and other liver support supps helps a lot. The healthier your liver the more igf you will convert.

IGF-1 of 955 has to be the Meso record.

 

[Type-IIx]

@Mighty-mouse keeps his at room temperature until reconstituted, and has had excellent results with lots of IGF-1 testing posted.

That's also fine, so long as you're not putting the GH under stress. Freezing and extreme heat, agitation, are stressors.

 

[Type-IIx]

You mean keep the powder form in the fridge?
Just to clarify, once it's liquid, it's in the fridge. When it's powder, it's in the freezer..

Just don't expose the peptide to freezing, incubation (extreme heat), or agitation in the solid state (powder). After reconstitution, keep in fridge, and only reconstitute about a week's worth at a time.

This applies more to generics than pharma preparations, where the antimicrobial preservative agents like phenols are designed in solution to prevent degradation of the peptide.

Here's some data on freezing:
Eckhardt, B. M., Oeswein, J. Q., & Bewley, T. A. (1991). Effects of freezing on aggregation of human growth hormone. Pharmaceutical Research, 08(11), 1360–1364. doi:10.1023/a:1015888704365

 

[Rubicon500]

IGF-1 of 955 has to be the Meso record.

A good buddy of mine hit 986 “naturally” so to speak.

Gained 86 lbs in 2 years or so without even trying , found out he had a Tumour on pituary gland. He had insane bone / muscle growth over that time , hands are close to twice the size now can barley find any jackets he can get his hands theu the cuff.

Surgery went well and all his horomones stabilized after , now he has the hard part of downsizing.

 

[Roco Bama]

A good buddy of mine hit 986 “naturally” so to speak.

Gained 86 lbs in 2 years or so without even trying , found out he had a Tumour on pituary gland. He had insane bone / muscle growth over that time , hands are close to twice the size now can barley find any jackets he can get his hands theu the cuff.

Surgery went well and all his horomones stabilized after , now he has the hard part of downsizing.

People with acromegaly don't actually experience increase muscle mass even though they can have igf levels as high as 5000. They tend to hold a lot of water.

How do muscles change? - Pituitary World News

Note: Muscle weakness affects the quality of life in people with acromegaly. Doctora Elena Valassi takes a fascinating look at what happens to muscles

www.pituitaryworldnews.org