HGH inhibiting weight loss suppression of GLP-1’s

[UncleBuns]

Drug Interaction Report: Mounjaro, somatropin

View detailed report of drug-drug and drug-food interactions for Mounjaro, somatropin

www.drugs.com

They seem to be working fine to me.

Oh, I see. I don't think you're reading it correctly though. The interaction is not talking about HGH reducing the hunger suppression from the GLP-1 drugs. It's basically saying that if you are using GLP-1 for diabetic purposes then HGH may be a bad idea because HGH causes insulin resistance. So the interaction they're talking about is totally different than what you were thinking.

 

[Ghoul]

I'm aware of one causing insulin resistance in one causing insulin sensitivity. They actually pair together well for that. I was referring to the original poster saying they read that HGH REDUCES the effects of tirz and sema. I've never heard of HGH diminishing GLP 1 drugs appetite suppression.

Here's an interesting interaction:

GLP-1 Receptor Agonists Induce Growth Hormone Secretion in Healthy Volunteers - PMC

Growth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under the feedback control of numerous nutritional and endocrine mediators. Glucagon-like peptide 1 receptor agonists ...

pmc.ncbi.nlm.nih.gov

 

[songsofpyramids]

Here's an interesting interaction:

GLP-1 Receptor Agonists Induce Growth Hormone Secretion in Healthy Volunteers - PMC

Growth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under the feedback control of numerous nutritional and endocrine mediators. Glucagon-like peptide 1 receptor agonists ...

pmc.ncbi.nlm.nih.gov

Increase gh but not igf1 is very interesting.

 

[bigtom343]

Increase gh but not igf1 is very interesting.

So does this mean we need to buy IGF from Tracy

 

[UncleBuns]

Here's an interesting interaction:

GLP-1 Receptor Agonists Induce Growth Hormone Secretion in Healthy Volunteers - PMC

Growth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under the feedback control of numerous nutritional and endocrine mediators. Glucagon-like peptide 1 receptor agonists ...

pmc.ncbi.nlm.nih.gov

That's interesting.

 

[UncleBuns]

So does this mean we need to buy IGF from Tracy

Why?

 

[AlexDavis43]

Why?

Because in that link, it appears GLP1s may hinder hGH-induced increases in IGF1.

 

[Ghoul]

Because in that link, it appears GLP1s may hinder hGH-induced increases in IGF1.

Maybe what you're looking for is some NA-931. Like Reta with a growth hormone / IGF kicker:

NA-931

NA-931 is for the treatment Diabetes Obesity and Alcohol Use Disorder

www.biomedind.com

 

[UncleBuns]

Because in that link, it appears GLP1s may hinder hGH-induced increases in IGF1.

That's not what it says.

 

[songsofpyramids]

Maybe what you're looking for is some NA-931. Like Reta with a growth hormone / IGF kicker:

View attachment 307076

NA-931

NA-931 is for the treatment Diabetes Obesity and Alcohol Use Disorder

www.biomedind.com

They’re really hopeful about that oral formulation. Is this pie in the sky dreaming or has there been a breakthrough?

 

[Ghoul]

They’re really hopeful about that oral formulation. Is this pie in the sky dreaming or has there been a breakthrough?

Pie on the sky I think. I can't say for sure, but it sounds like another one that's going to end up on the trash heap of attempts at hitting the jackpot.

 

[songsofpyramids]

Pie on the sky I think. I can't say for sure, but it sounds like another one that's going to end up on the trash heap of attempts at hitting the jackpot.

“We’ll just sprinkle a little Increlex on it.”

 

[AlexDavis43]

That's not what it says.

See figures 1C & 1D.

 

[UncleBuns]

See figures 1C & 1D.

It shows that during the chronic administration test IGF 1 lowered only slightly. These people were not taking rHGH. Here is a section from the paper:

"IGF-1 values did not reflect the changes in GH secretion and were somewhat lower after chronic treatment. Acute GLP-1 infusion has been demonstrated to decrease insulin-like growth factor-binding protein-3 (IGFBP-3) levels in humans, and this effect may explain the observed decrease in total IGF-1 levels [32]. Alternatively, changes in GH and IGF-1 levels may also reflect the decrease in body weight in the liraglutide trial."

The subjects also were losing weight which means they were eating less calories. I would imagine that they were eating less carbohydrates and less carbohydrate. Consumption means less insulin release overall which would lower IGF-1 production.

Seems totally insignificant to me.