HUGE McBIGLARGE
Member
You got a source on that? If so I want a refund of the last 10 estrogen tests I’ve taken with them lol
MESO-Rx
Anabolic Steroids
High e2 on 2.5mg anastrozole per week
- Thread starter HUGE McBIGLARGE
- Start date
IceIcebaby22
New Member
Sorry mate just saw this now. I don't have any sources to hand. You can search LC/MS or LCMS from the search bar on this site, loads of good information and then decide how you want to go from there.
As a disclaimer I don't want to say that this is necessarily the cause for your high estrogen level , however I personally would only test from a lab that using the LC/MS testing. I know tren 100% gives a false estrogen reading using the eclipse method.
Maybe a more knowledgeable member could chime in?
Email Medichecks to check if they use the LC/MS assay to check for estrogen. I don't think you may get a refund as the their method is generally reliable for non AAS users or if you are just using test alone.
When I chased it up with MC they could not tell me the difference between the testing method nor explain how they test for estrogen instead they sent me the name of the manufacture of their lab equipment and told me that their test are as accurate as the NHS.
HUGE McBIGLARGE
Member
So would that mean you’d consider them reliable for test/hcg/ai?
update
HUGE McBIGLARGE
Member
What with?
HUGE McBIGLARGE
Member
I have some letrozole raws on the way. Based on the study I’ve read, letrozole is very potent, and 0.1mg is similarly effective to 2.5mg.
I’m going to mix letrozole with some MCC and do “geometric dilution” by mixing 1 part letro with 1 part MCC, put it in a bottle, shake the fuck outta it, then repeating with 2 parts MCC, 4 parts, 8 parts, 16 etc.
I’ll then eat 0.2mg letro each day on an empty stomach, and retest my e2.
I’m going to mix letrozole with some MCC and do “geometric dilution” by mixing 1 part letro with 1 part MCC, put it in a bottle, shake the fuck outta it, then repeating with 2 parts MCC, 4 parts, 8 parts, 16 etc.
I’ll then eat 0.2mg letro each day on an empty stomach, and retest my e2.
HUGE McBIGLARGE
Member
I’ve not taken any MCR agonists for a few months now so I can properly test how I am without them. I intend on starting them back up in about a week.
At first PT141 at around 300mcg a day worked really well. I did find the dose needed to be higher after a few weeks to get the same effect. Not sure if that’s due to building a long-term drug tolerance or simply due to some underlying mechanisms trying to reach homeostasis quickly. How well PT141 worked was proportionate to how nauseous I felt lol
Either way, around 700mcg a day for a few months was enough to get very good results during treatment.
My sexual function was better after cession of PT141 than it was prior to PT141. So it certainly didn’t leave me worse off.
I like doing the same. Every 3-4 days 250mcg of PT141 and no consumption of porn. Massively improved Sex life. 5mg Cialis daily to that and some HCG for good loads and your girlfriend will be happy.
I've done 1g and 1.5g and didn't feel any sexual effect, besides nausea, flushing and raging boners. It's amazing such a low dosage works for you
Liter O' Test
Member
yeah i think yu should just try letro at like ..25 doses eod
how much gear are you on noW?
estrogen is easier for me to manage with more frequency and larger doses of both a.i and gear. there is this shit zone between 200mg-400mg a lot of guys find impossible to dial in, doesnt explain why the adex wasnt working for you but just throwing this out there,
for example when i was taking 1mg adex per day, thats keeping my aromatase inhibited by 80-90% at all times, so even if i increase the gear dose, the fluctation is less because my total estrogen baseline is already 80-90% less. theres only so much aromatase in the body.
how much gear are you on noW?
estrogen is easier for me to manage with more frequency and larger doses of both a.i and gear. there is this shit zone between 200mg-400mg a lot of guys find impossible to dial in, doesnt explain why the adex wasnt working for you but just throwing this out there,
for example when i was taking 1mg adex per day, thats keeping my aromatase inhibited by 80-90% at all times, so even if i increase the gear dose, the fluctation is less because my total estrogen baseline is already 80-90% less. theres only so much aromatase in the body.
HUGE McBIGLARGE
Member
315mg TE P/W. Injected EoD
It did work, just not very well. Same with the aromasin
Liter O' Test
Member
I adjust my gear dose to my adex dose, something to keep in mind going forward once you get closer to dialing it in
HUGE McBIGLARGE
Member
I am now of the opinion that I do need a hefty dose of an AI to get therapeutic effect.
I’ve been taking 3mg anastrozole and 315mg TE across a week, then abruptly stopping the anastrozole for a few days and continuing at 1mg for a week. Then i repeat back at 3mg. And I’ve noticed a complete lack of nocturnal erections at the 1mg per week, which return within a few days of being back at 3mg.
This would be case closed, except I’ve got no idea how to get my e2 levels just right. I cant imagine feeling the difference between 3mg and 3.5mg per week, so I’ve gotta go based on bloods. But my e2 is all over the place on the blood tests.
45mg TE EoD with 2.5mg anastrozole per week and my e2 was 295pmol/l
90mg TE EoD with 2.5mg anastrozole per week and my e2 was 160pmol/l
So my e2 can range from roughly 1 fold to 3.68 fold depending on the day lol. Makes testing seem pointless. The only explanation is that fingerprick tests with medichecks are extremely inaccurate.
When my letro gets here I’ll roll with that and do venous tests going forward. If the blood tests continue to be pointless, I’m gonna have to feelz my way to the right dose.
I’ve been taking 3mg anastrozole and 315mg TE across a week, then abruptly stopping the anastrozole for a few days and continuing at 1mg for a week. Then i repeat back at 3mg. And I’ve noticed a complete lack of nocturnal erections at the 1mg per week, which return within a few days of being back at 3mg.
This would be case closed, except I’ve got no idea how to get my e2 levels just right. I cant imagine feeling the difference between 3mg and 3.5mg per week, so I’ve gotta go based on bloods. But my e2 is all over the place on the blood tests.
45mg TE EoD with 2.5mg anastrozole per week and my e2 was 295pmol/l
90mg TE EoD with 2.5mg anastrozole per week and my e2 was 160pmol/l
So my e2 can range from roughly 1 fold to 3.68 fold depending on the day lol. Makes testing seem pointless. The only explanation is that fingerprick tests with medichecks are extremely inaccurate.
When my letro gets here I’ll roll with that and do venous tests going forward. If the blood tests continue to be pointless, I’m gonna have to feelz my way to the right dose.
Ateam2023
Member
so you are checking your e2 via "finger prick " tests? And not just a regular blood draw out of a vein?
HUGE McBIGLARGE
Member
Most of the e2 tests have been fingerprick, yes.
The most recent e2 test that was venous is as follows:
-54mg TE EoD
-1mg anastrozole per week. Dosed 4x per week
-e2: 287 pmol/l
So that e2 is consistent with the fingerprick tests. Admittedly, the sample was still posted, so maybe the stagnant blood somehow gets more estrogeny.
Ateam2023
Member
honestly i'm not familiar with that pmol/l type of a reading , All my e2 is read in pg/ml, and when i try to convert the two it gives me an insane pg/ml reading from the conversion of pmol/l to pg/ml, any insights?
HUGE McBIGLARGE
Member
Liter O' Test
Member
bro your judging e2 by morning wood and finger pricks?
also, e2 tends to have some lag time, meaning some guys get gyno symptoms, take a,i, then gyno symptoms seem to continue or get worse and then they increase a.i even more, but in reality the symptoms had a "lag" and the estrogen in the cell is different than the estrogen in the blood stream, it can be complicated.
like if i dont take a.i for a few days, I'll start taking it again THEN might get some nipple or greasy face..
you gotta just pick a dose that makes you feel OK, that preferably you can dose ED. then ride it out and get bloodwork so you have some idea of where to go.
the finger pricks arent accurate... also adex has a half life of 24 hours... so if you are dosing that 4x per week and are a high aromatizer, like during the week half the time your adex is like really dropping off, IMO, could be wrong. but you wouldn't dose acetate EOD if you wanted to mitigate sides, so your e2 control is going all up and down, and if youre alsready sensitive to estrogen, that means the swing is even bigger than other peoples, so it can work for them if they dont aromatize as much, but if you do, then your swing between doses is larger.
HUGE McBIGLARGE
Member
Yeah lol. The venous tests are as consistently inconsistent as the fingerprick ones. So it’s not like the fingerprick ones are noticeably under or over representing my venous e2.
Yeah I totally get that. The symptomatic expression of drugs can take longer than the “tmax” of the drug. And drugs like losartan have a 2 hour half life, yet their efficacy lasts at least 24.
Yeah thanks man. Hoping to do that going forward.
With the testing, I test it half way between the average drug dosages to get a better representation of my average serum levels. So if I dose adex 4x per week, I’ll do the blood draw ideally 21 hours after my last adex dose. Because 24 hours * 7 days / 4 adex doses / half = 21.
But I do agree this is less than ideal, and I may be crashing my e2 followed by letting it rise.
I would have dosed the adex daily, but doing any less than 0.25mg is difficult due to the teeny tiny tablets. Hopefully if/when my letrozole gets here I can dose that daily as low as I want.
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